Suchergebnis: Katalogdaten im Herbstsemester 2016

MAS in Medizinphysik Information
Fachrichtung: Allg. Medizinphysik und Biomedizinisches Ingenieurwesen
Vertiefung Biocompatible Materials
Wahlfächer
NummerTitelTypECTSUmfangDozierende
151-0255-00LEnergy Conversion and Transport in BiosystemsW4 KP2V + 1UD. Poulikakos, A. Ferrari
KurzbeschreibungTheorie und Anwendung von Thermodynamik und Energieerhaltung in biologischen Systemen mit Schwerpunkt auf Zellebene.
LernzielTheorie und Anwendung von Energieerhaltung auf Zellebene. Verständnis für die grundlegenden Stofftransport-Kreisläufe in menschlichen Zellen und die Mechanismen, welche diese Kreisläufe beeinflussen. Parallelen zu anderen Gebieten im Ingenieurswesen erkennen. Wärme- und Massentransport Prozesse in der Zelle, Kraft Entwicklung der Zelle, und die Verbindung zu modernen biomedizinischen Technologien.
InhaltMassentransportmodelle für den Transport von chemischen Spezies in der menschlichen Zelle. Organisation und Funktion der Zellmembran und des Zytoskeletts. Die Rolle molekularer Motoren in der Kraftentwicklung der Zelle und deren Funktion in der Fortbewegung der Zelle. Beschreibung der Funktionsweise dieser Systeme sowie der experimentellen Analyse und Simulationen um sie besser zu verstehen. Einführung in den Zell-Metabolismus, Zell-Energietransport und die Zelluläre Thermodynamik.
SkriptKursmaterial wird in Form von Hand-outs verteilt.
LiteraturNotizen sowie Referenzen aus der Vorlesung.
327-1101-00LBiomineralization Information W2 KP2GK.‑H. Ernst
KurzbeschreibungThe course addresses undergraduate and graduate students interested in getting introduced into the basic concepts of biomineralization.
LernzielThe course aims to introduce the basic concepts of biomineralization and the underlying principles, such as supersaturation, nucleation and growth of minerals, the interaction of biomolecules with mineral surfaces, and cell biology of inorganic materials creation. An important part of this class is the independent study and the presentation of original literature from the field.
InhaltBiomineralization is a multidisciplinary field. Topics dealing with biology, molecular and cell biology, solid state physics, mineralogy, crystallography, organic and physical chemistry, biochemistry, dentistry, oceanography, geology, etc. are addressed. The course covers definition and general concepts of biomineralization (BM)/ types of biominerals and their function / crystal nucleation and growth / biological induction of BM / control of crystal morphology, habit, shape and orientation by organisms / strategies of compartmentalization / the interface between biomolecules (peptides, polysaccharides) and the mineral phase / modern experimental methods for studying BM phenomena / inter-, intra, extra- and epicellular BM / organic templates and matrices for BM / structure of bone, teeth (vertebrates and invertebrates) and mollusk shells / calcification / silification in diatoms, radiolaria and plants / calcium and iron storage / impact of BM on lithosphere and atmosphere/ evolution / taxonomy of organisms.

1. Introduction and overview
2. Biominerals and their functions
3. Chemical control of biomineralization
4. Control of morphology: Organic templates and additives
5. Modern methods of investigation of BM
6. BM in matrices: bone and nacre
7. Vertebrate teeth
8. Invertebrate teeth
9. BM within vesicles: calcite of coccoliths
10. Silica
11. Iron storage and mineralization
SkriptScript with more than 600 pages with many illustrations will be distributed free of charge.
Literatur1) S. Mann, Biomineralization, Oxford University Press, 2001, Oxford, New York
2) H. Lowenstam, S. Weiner, On Biomineralization, Oxford University Press, 1989, Oxford
3) P. M. Dove, J. J. DeYoreo, S. Weiner (Eds.) Biomineralization, Reviews in Mineralogoy & Geochemistry Vol. 54, 2003
Voraussetzungen / BesonderesEach attendee is required to present a publication from the field. The selection of key papers is provided by the lecturer.
No special requirements are needed for attending. Basic knowledge in chemistry and cell biology is expected.
376-1103-00LFrontiers in NanotechnologyW4 KP4VV. Vogel, weitere Dozierende
KurzbeschreibungMany disciplines are meeting at the nanoscale, from physics, chemistry to engineering, from the life sciences to medicine. The course will prepare students to communicate more effectively across disciplinary boundaries, and will provide them with deep insights into the various frontiers.
LernzielBuilding upon advanced technologies to create, visualize, analyze and manipulate nano-structures, as well as to probe their nano-chemistry, nano-mechanics and other properties within manmade and living systems, many exciting discoveries are currently made. They change the way we do science and result in so many new technologies.

The goal of the course is to give Master and Graduate students from all interested departments an overview of what nanotechnology is all about, from analytical techniques to nanosystems, from physics to biology. Students will start to appreciate the extent to which scientific communities are meeting at the nanoscale. They will learn about the specific challenges and what is currently “sizzling” in the respective fields, and learn the vocabulary that is necessary to communicate effectively across departmental boundaries.

Each lecturer will first give an overview of the state-of-the art in his/her field, and then describe the research highlights in his/her own research group. While preparing their Final Projects and discussing them in front of the class, the students will deepen their understanding of how to apply a range of new technologies to solve specific scientific problems and technical challenges. Exposure to the different frontiers will also improve their ability to conduct effective nanoscale research, recognize the broader significance of their work and to start collaborations.
InhaltStarting with the fabrication and analysis of nanoparticles and nanostructured materials that enable a variety of scientific and technical applications, we will transition to discussing biological nanosystems, how they work and what bioinspired engineering principles can be derived, to finally discussing biomedical applications and potential health risk issues. Scientific aspects as well as the many of the emerging technologies will be covered that start impacting so many aspects of our lives. This includes new phenomena in physics, advanced materials, novel technologies and new methods to address major medical challenges.
SkriptAll the enrolled students will get access to a password protected website where they can find pdf files of the lecture notes, and typically 1-2 journal articles per lecture that cover selected topics.
402-0674-00LPhysics in Medical Research: From Atoms to Cells Information W6 KP2V + 1UB. K. R. Müller
KurzbeschreibungScanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells.
LernzielThe lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour.

As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced.

The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes.

High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering.

Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body.

Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function.

3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented.

Visiting clinical research in a leading university hospital will show the usefulness of the lecture series.
Vertiefung Molecular Biology and Biophysics
Kernfächer
NummerTitelTypECTSUmfangDozierende
227-0945-00LCell and Molecular Biology for Engineers I
This course is part I of a two-semester course.
W3 KP3GC. Frei
KurzbeschreibungThe course gives an introduction into cellular and molecular biology, specifically for students with a background in engineering. The focus will be on the basic organization of eukaryotic cells, molecular mechanisms and cellular functions. Textbook knowledge will be combined with results from recent research and technological innovations in biology.
LernzielAfter completing this course, engineering students will be able to apply their previous training in the quantitative and physical sciences to modern biology. Students will also learn the principles how biological models are established, and how these models can be tested.
InhaltLectures will include the following topics: DNA, chromosomes, RNA, protein, genetics, gene expression, membrane structure and function, vesicular traffic, cellular communication, energy conversion, cytoskeleton, cell cycle, cellular growth, apoptosis, autophagy, cancer, development and stem cells.

In addition, three journal clubs will be held, where one/two publictions will be discussed (part I: 1 Journal club, part II: 2 Journal Clubs). For each journal club, students (alone or in groups of up to three students) have to write a summary and discussion of the publication. These written documents will be graded and count as 25% for the final grade.
SkriptScripts of all lectures will be available.
Literatur"Molecular Biology of the Cell" (6th edition) by Alberts, Johnson, Lewis, Raff, Roberts, and Walter.
551-1295-00LIntroduction to Bioinformatics: Concepts and Applications Information W6 KP4GW. Gruissem, K. Bärenfaller, A. Caflisch, G. Capitani, J. Fütterer, M. Robinson, A. Wagner
KurzbeschreibungStorage, handling and analysis of large datasets have become essential in biological research. The course will introduce students to a number of applications of bioinformatics in biology. Freely accessible software tools and databases will be explained and explored in theory and praxis.
LernzielIntroduction to Bioinformatics I: Concepts and Applications (formerly Bioinformatics I) will provide students with the theoretical background of approaches to store and retrieve information from large databases. Concepts will be developed how DNA sequence information can be used to understand phylogentic relationships, how RNA sequence relates to structure, and how protein sequence information can be used for genome annotation and to predict protein folding and structure. Students will be introduced to quantitative methods for measuring gene expression and how this information can be used to model gene networks. Methods will be discussed to construct protein interaction maps and how this information can be used to simulate dynamic molecular networks.

In addition to the theoretical background, the students will develop hands-on experiences with the bioinformatics methods through guided exercises. The course provides students from different backgrounds with basic training in bioinformatics approaches that have impact on biological, chemical and physics experimentation. Bioinformatics approaches draw significant expertise from mathematics, statistics and computational science.

Although "Intoduction to Bioinformatics I" will focus on theory and praxis of bioinformatics approaches, the course provides an important foundation for the course "Introduction to Bioinformatics II: Fundamentals of computer science, modeling and algorithms" that will be offered in the following semester.
InhaltBioinformatics I will cover the following topics:

From genes to databases and information
BLAST searches
Prediction of gene function and regulation
RNA structure prediction
Gene expression analysis using microarrays
Protein sequence and structure databases
WWW for bioinformatics
Protein sequence comparisons
Proteomics and de novo protein sequencing
Protein structure prediction
Cellular and protein interaction networks
Molecular dynamics simulation
551-1601-00LBiophysics of Biological Macromolecules Information
Findet dieses Semester nicht statt.
The course will only take place with a minimum of 4 participants.
W6 KP2V + 1UG. Wider, F. Allain
KurzbeschreibungThis lecture course targets physics students and students of interdisciplinary sciences (major physics) for their education in biophysics. In this course the basics of molecular biology are presented bearing in mind the special interests of the physics students.
LernzielBasics of molecular biology and biophysics in in view of the special interest of students in physics.
InhaltThis lecture course targets physics students and students of interdisciplinary sciences (major physics) for their education in biophysics. In this course the basics of molecular biology are presented bearing in mind the special interests of the physics students. The topics include: properties of biological macromolecules, introduction to the genetic system of E.coli bacteria, transcription, translation, discussion of structure and function of proteins, quantitative description of enzyme function and allosteric interactions, biotechnology, introduction to optical spectroscopy, X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy of biopolymers in solution.
Skript- additional documentation in support of text book
Voraussetzungen / Besonderessmall classes with active participation of students
Praktika
NummerTitelTypECTSUmfangDozierende
465-0800-00LPractical Work Belegung eingeschränkt - Details anzeigen
Nur für MAS in Medizinphysik
O4 KPexterne Veranstalter
KurzbeschreibungThe practical work is designed to train the students in the solution of a specific problem and provides insights in the field of the selected MAS specialization. Tutors propose the subject of the project, the project plan, and the roadmap together with the student, as well as monitor the overall execution.
LernzielThe practical work is aimed at training the student’s capability to apply and connect specific skills acquired during the MAS specialization program towards the solution of a focused problem.
Wahlfächer
NummerTitelTypECTSUmfangDozierende
327-1101-00LBiomineralization Information W2 KP2GK.‑H. Ernst
KurzbeschreibungThe course addresses undergraduate and graduate students interested in getting introduced into the basic concepts of biomineralization.
LernzielThe course aims to introduce the basic concepts of biomineralization and the underlying principles, such as supersaturation, nucleation and growth of minerals, the interaction of biomolecules with mineral surfaces, and cell biology of inorganic materials creation. An important part of this class is the independent study and the presentation of original literature from the field.
InhaltBiomineralization is a multidisciplinary field. Topics dealing with biology, molecular and cell biology, solid state physics, mineralogy, crystallography, organic and physical chemistry, biochemistry, dentistry, oceanography, geology, etc. are addressed. The course covers definition and general concepts of biomineralization (BM)/ types of biominerals and their function / crystal nucleation and growth / biological induction of BM / control of crystal morphology, habit, shape and orientation by organisms / strategies of compartmentalization / the interface between biomolecules (peptides, polysaccharides) and the mineral phase / modern experimental methods for studying BM phenomena / inter-, intra, extra- and epicellular BM / organic templates and matrices for BM / structure of bone, teeth (vertebrates and invertebrates) and mollusk shells / calcification / silification in diatoms, radiolaria and plants / calcium and iron storage / impact of BM on lithosphere and atmosphere/ evolution / taxonomy of organisms.

1. Introduction and overview
2. Biominerals and their functions
3. Chemical control of biomineralization
4. Control of morphology: Organic templates and additives
5. Modern methods of investigation of BM
6. BM in matrices: bone and nacre
7. Vertebrate teeth
8. Invertebrate teeth
9. BM within vesicles: calcite of coccoliths
10. Silica
11. Iron storage and mineralization
SkriptScript with more than 600 pages with many illustrations will be distributed free of charge.
Literatur1) S. Mann, Biomineralization, Oxford University Press, 2001, Oxford, New York
2) H. Lowenstam, S. Weiner, On Biomineralization, Oxford University Press, 1989, Oxford
3) P. M. Dove, J. J. DeYoreo, S. Weiner (Eds.) Biomineralization, Reviews in Mineralogoy & Geochemistry Vol. 54, 2003
Voraussetzungen / BesonderesEach attendee is required to present a publication from the field. The selection of key papers is provided by the lecturer.
No special requirements are needed for attending. Basic knowledge in chemistry and cell biology is expected.
376-1103-00LFrontiers in NanotechnologyW4 KP4VV. Vogel, weitere Dozierende
KurzbeschreibungMany disciplines are meeting at the nanoscale, from physics, chemistry to engineering, from the life sciences to medicine. The course will prepare students to communicate more effectively across disciplinary boundaries, and will provide them with deep insights into the various frontiers.
LernzielBuilding upon advanced technologies to create, visualize, analyze and manipulate nano-structures, as well as to probe their nano-chemistry, nano-mechanics and other properties within manmade and living systems, many exciting discoveries are currently made. They change the way we do science and result in so many new technologies.

The goal of the course is to give Master and Graduate students from all interested departments an overview of what nanotechnology is all about, from analytical techniques to nanosystems, from physics to biology. Students will start to appreciate the extent to which scientific communities are meeting at the nanoscale. They will learn about the specific challenges and what is currently “sizzling” in the respective fields, and learn the vocabulary that is necessary to communicate effectively across departmental boundaries.

Each lecturer will first give an overview of the state-of-the art in his/her field, and then describe the research highlights in his/her own research group. While preparing their Final Projects and discussing them in front of the class, the students will deepen their understanding of how to apply a range of new technologies to solve specific scientific problems and technical challenges. Exposure to the different frontiers will also improve their ability to conduct effective nanoscale research, recognize the broader significance of their work and to start collaborations.
InhaltStarting with the fabrication and analysis of nanoparticles and nanostructured materials that enable a variety of scientific and technical applications, we will transition to discussing biological nanosystems, how they work and what bioinspired engineering principles can be derived, to finally discussing biomedical applications and potential health risk issues. Scientific aspects as well as the many of the emerging technologies will be covered that start impacting so many aspects of our lives. This includes new phenomena in physics, advanced materials, novel technologies and new methods to address major medical challenges.
SkriptAll the enrolled students will get access to a password protected website where they can find pdf files of the lecture notes, and typically 1-2 journal articles per lecture that cover selected topics.
402-0674-00LPhysics in Medical Research: From Atoms to Cells Information W6 KP2V + 1UB. K. R. Müller
KurzbeschreibungScanning probe and diffraction techniques allow studying activated atomic processes during early stages of epitaxial growth. For quantitative description, rate equation analysis, mean-field nucleation and scaling theories are applied on systems ranging from simple metallic to complex organic materials. The knowledge is expanded to optical and electronic properties as well as to proteins and cells.
LernzielThe lecture series is motivated by an overview covering the skin of the crystals, roughness analysis, contact angle measurements, protein absorption/activity and monocyte behaviour.

As the first step, real structures on clean surfaces including surface reconstructions and surface relaxations, defects in crystals are presented, before the preparation of clean metallic, semiconducting, oxidic and organic surfaces are introduced.

The atomic processes on surfaces are activated by the increase of the substrate temperature. They can be studied using scanning tunneling microscopy (STM) and atomic force microscopy (AFM). The combination with molecular beam epitaxy (MBE) allows determining the sizes of the critical nuclei and the other activated processes in a hierarchical fashion. The evolution of the surface morphology is characterized by the density and size distribution of the nanostructures that could be quantified by means of the rate equation analysis, the mean-field nucleation theory, as well as the scaling theory. The surface morphology is further characterized by defects and nanostructure's shapes, which are based on the strain relieving mechanisms and kinetic growth processes.

High-resolution electron diffraction is complementary to scanning probe techniques and provides exact mean values. Some phenomena are quantitatively described by the kinematic theory and perfectly understood by means of the Ewald construction. Other phenomena need to be described by the more complex dynamical theory. Electron diffraction is not only associated with elastic scattering but also inelastic excitation mechanisms that reflect the electronic structure of the surfaces studied. Low-energy electrons lead to phonon and high-energy electrons to plasmon excitations. Both effects are perfectly described by dipole and impact scattering.

Thin-films of rather complex organic materials are often quantitatively characterized by photons with a broad range of wavelengths from ultra-violet to infra-red light. Asymmetries and preferential orientations of the (anisotropic) molecules are verified using the optical dichroism and second harmonic generation measurements. These characterization techniques are vital for optimizing the preparation of medical implants and the determination of tissue's anisotropies within the human body.

Cell-surface interactions are related to the cell adhesion and the contractile cellular forces. Physical means have been developed to quantify these interactions. Other physical techniques are introduced in cell biology, namely to count and sort cells, to study cell proliferation and metabolism and to determine the relation between cell morphology and function.

3D scaffolds are important for tissue augmentation and engineering. Design, preparation methods, and characterization of these highly porous 3D microstructures are also presented.

Visiting clinical research in a leading university hospital will show the usefulness of the lecture series.
535-0423-00LDrug Delivery and Drug TargetingW2 KP2VJ.‑C. Leroux, D. Brambilla
KurzbeschreibungDie Studierenden erwerben einen Überblick über derzeit aktuelle Prinzipien, Methoden und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Damit sind die Studierenden in der Lage, das Gebiet gemäss wissenschaftlichen Kriterien zu verstehen und zu beurteilen.
LernzielDie Studierenden verfügen über einen Überblick über derzeit aktuelle Prinzipien und Systeme zur kontrollierten Abgabe und zum Targeting von Arzneistoffen. Im Vordergrund der Lehrveranstaltung steht die Entwicklung von Fähigkeiten zum Verständnis der betreffenden Technologien und Methoden, ebenso wie der Möglichkeiten und Grenzen ihres therapeutischen Einsatzes. Im Zentrum stehen therapeutische Peptide, Proteine, Nukleinsäuren und Impfstoffe.
InhaltDer Kurs behandelt folgende Themen: Arzneistoff-targeting und Freigabeprinzipien, Radiopharmaka, makromolekulare Arzneistofftransporter, Liposomen, Mizellen, Mikro/Nanopartikel, Gele und Implantate, Anwendung von Impfstoffen, Abgabe von Wirkstoffen im Rahmen von Tissue engineering, Abgabe im Gastrointestinaltrakt, synthetische Transporter für Arzneistoffe auf Nukleinsäurebasis, ophthalmische Vehikel und neue Trends in transdermaler und nasaler Arzneistofffreigabe.
SkriptAusgewählte Skripten, Vorlesungsunterlagen und unterstützendes Material werden entweder direkt an der Vorlesung ausgegeben oder sind über das Web zugänglich:

http://www.galenik.ethz.ch/teaching/drug_del_drug_targ

Diese Website enthält auch zusätzliche Unterlagen zu peroralen Abgabesystemen, zur gastrointestinalen Passage von Arzneiformen, transdermalen Systemen und über Abgabesysteme für alternative Absorptionswege. Diese Stoffgebiete werden speziell in der Vorlesung Galenische Pharmazie II behandelt.
LiteraturY. Perrie, T. Rhades. Pharmaceutics - Drug Delivery and Targeting, second edition, Pharmaceutical Press, London and Chicago, 2012.

Weitere Literatur in der Vorlesung.
551-1615-00LNMR Methods for Studies of Biological Macromolecules Information
Prerequisites: Basic knowledge in biological NMR spectroscopy.
W1 KP1SG. Wider
KurzbeschreibungSeminar series on technical aspects of high resolution nuclear magnetic resonance (NMR) spectroscopy with biological macromolecules.
LernzielIntroduction and discussion of advanced methods for recording and analysis of NMR data with biological macromolecules.
InhaltSeminar series on technical aspects of high-resolution nuclear magnetic resonance (NMR) spectroscopy with biological macromolecules.
551-1619-00LStrukturbiologieW1 KP1KR. Glockshuber, F. Allain, N. Ban, K. Locher, E. Weber-Ban, G. Wider, K. Wüthrich
KurzbeschreibungDer Kurs besteht aus Forschungs-Seminaren aus dem Gebiet der Strukturbiologie, Biochemie und Biophysik, die von Wissenschaftlern des Nationalen Schwerpunktprogramms (NCCR) Strukturbiologie gehalten werden, als auch von externen Sprechern. Informationen über die einzelnen Vorträge:
http://www.structuralbiology.uzh.ch/educ002.asp
http://www.biol.ethz.ch/dbiol-cal/index
LernzielZiel des Kurses ist es, Doktorierenden und Postdoktoranden einen breiten Überblick über die jüngsten Entwicklungen auf dem Gebiet der Strukturbiologie, Biochemie und Biophysik zu vermitteln
551-0307-00LMolecular and Structural Biology I: Protein Structure and Function Information
D-BIOL BSc students are obliged to take part I and part II (next semester) as a two-semester course
W3 KP2VR. Glockshuber, K. Locher, E. Weber-Ban
KurzbeschreibungBiophysik der Proteinfaltung, Membranproteine und Biophysik von Membranen, enzymatischen Katalyse, katalytische RNA und RNAi, aktuelle Themen in Proteinbiophysik und Strukturbiologie.
LernzielVerständnis von Struktur/Funktionsbeziehungen in Proteinen, Proteinfaltung, Vertiefung der Kenntnisse in Biophysik, in physikalischen Messmethoden und modernen Methoden der Proteinreinigung und Protein-Mikroanalytik.
SkriptSkripte zu einzelnen Themen der Vorlesung sind unter http://www.mol.biol.ethz.ch/teaching abgelegt.
LiteraturGrundlagen:
- Creighton, T.E., Proteins, Freeman, (1993).
- Fersht, A., Enzyme, Structure and Mechanism in Protein Science (1999), Freeman.
- Berg, Tymoczko, Stryer: Biochemistry (5th edition), Freeman (2001).

Aktuelle Themen: Literatur wird jeweils in der Vorlesung angegeben
636-0003-00LBiological Engineering and BiotechnologyW6 KP3VM. Fussenegger
KurzbeschreibungBiological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Lernziel1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development.
SkriptHandsout during the course.
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