551-0434-00L  NMR Spectroscopy in Biology

Semester Spring Semester 2016
Lecturers F. Allain, G. Wider, K. Wüthrich
Periodicity yearly course
Language of instruction English
Comment Number of participants limited to 8.


Abstract In this block course, students actively participate in ongoing research projects in the research groups of Profs. Allain, Wider and Wüthrich. The students will be tutored in their experimental work by doctoral or postdoctoral students. In addition, the course includes specific lectures that provide the theoretical background for the experimental work, as well as excercises and literature work.
Objective The course provides first "hands on" insight into applications of NMR spectroscopy in biological sciences. The course should enable the students to understand the potential and limitations of NMR applied to biological problems.
Content The topics include studies of proteins, RNA and protein-RNA interactions,

Participation in one of the following projects will be possible:
- NMR of RNA
- NMR of several protein-RNA complexes (hnRNPF, nPTB, SR proteins)
- NMR studies of glycoproteins
- dynamics of protein-RNA complexes
- Segmental isotopic labeling to study multidomain proteins
-Structural and dynamic properties of FtsZ, the bacterial homolog of tubulin
- investigations of the ubiquitinom
- NMR Methods Development
Lecture notes No script
Literature Lists of individual reading assignments will be handed out.