Rudolf Glockshuber: Catalogue data in Autumn Semester 2023 |
| Name | Prof. em. Dr. Rudolf Glockshuber |
| Field | Molecular Biology |
| Address | Inst. f. Molekularbiol.u.Biophysik ETH Zürich, HPK F 7 Otto-Stern-Weg 5 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 68 19 |
| rudi@mol.biol.ethz.ch | |
| Department | Biology |
| Relationship | Professor emeritus |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||
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| 551-0125-00L | Fundamentals of Biology I: From Molecules to the Biochemistry of Cells | 6 credits | 5G | J. Vorholt-Zambelli, N. Ban, R. Glockshuber, K. Locher, J. Piel | ||||||||||||||||||||
| Abstract | The lecture provides an introduction to the basics of biochemistry and molecular biology as well as evolutionary principles. The focus is on bacteria and archaea under consideration of universal concepts. | |||||||||||||||||||||||
| Learning objective | Introduction to biochemistry, molecular biology and evolutionary principles | |||||||||||||||||||||||
| Content | The lecture introduces biology as an interdisciplinary science. Links to physics and chemistry will manifest as biological processes that operate within the laws of thermodynamics and are rooted in elements, molecules and chemical reactions. The transition from geochemistry to biochemistry is discussed and considered in relation to the origin of life. Evolutionary principles are introduced and resulting processes are used as a guiding principle. Unifying concepts in biology are presented, including the structure and function of cellular macromolecules and the ways in which hereditary information is encoded, decoded and replicated. Central principles of universal energy conversion are looked at, starting from redox processes and focusing on bacteria and archaea. Finally, biological processes are put into an ecosystems perspective. The lecture is divided into different sections: 1. Geochemical perspectives on Earth and introduction to evolution 2. Building blocks of life 3. Macromolecules: Proteins 4. Membranes and transport across the plasma membrane 5. Universal mechanisms of inheritance, transcription and translation 6. Reaction Kinetics, binding equilibria and enzymatic catalysis 7. Essentials of Catabolism 8. Essentials of Anabolism 9. Metabolism and biogeochemical cycling of elements | |||||||||||||||||||||||
| Lecture notes | The newly conceived lecture is supported by scripts. | |||||||||||||||||||||||
| Literature | The lecture is supported by scripts. The lecture contains elements of "Brock Biology of Microorganisms", Madigan et al. 15th edition, Pearson und "Biochemistry" (Stryer), Berg et al. 9th edition, Macmillan international. | |||||||||||||||||||||||
Competencies |
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| 551-0307-00L | Molecular and Structural Biology I: Protein Structure and Function D-BIOL students are obliged to take part I and part II (next semester) as a two-semester course | 3 credits | 2V | R. Glockshuber, K. Locher, E. Weber-Ban | ||||||||||||||||||||
| Abstract | Biophysics of protein folding, membrane proteins and biophysics of membranes, enzymatic catalysis, catalytic RNA and RNAi, current topics in protein biophysics and structural biology. | |||||||||||||||||||||||
| Learning objective | Understanding of structure-function relationships in proteins and in protein folding, detailed understanding of biophysics and physical methods as well as modern methods for protein purification and microanalytics. | |||||||||||||||||||||||
| Lecture notes | Scripts on the individual topics can be found under http://www.mol.biol.ethz.ch/teaching. | |||||||||||||||||||||||
| Literature | Basics: - Creighton, T.E., Proteins, Freeman, (1993) - Fersht, A., Enzyme, Structure and Mechanism in Protein Science (1999), Freeman. - Berg, Tymoczko, Stryer: Biochemistry (5th edition), Freeman (2001). Current topics: References will be given during the lectures. . | |||||||||||||||||||||||