Cornelia Halin Winter: Catalogue data in Autumn Semester 2021 |  |
| Name | Prof. Dr. Cornelia Halin Winter |
| Field | Pharmaceutical Immunology |
| Address | Inst. f. Pharmazeutische Wiss. ETH Zürich, HCI G 490.2 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 29 62 |
| cornelia.halin@pharma.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 535-0001-00L | Introduction to Pharmaceutical Sciences I  | 2 credits | 2V | J. Hall, K.‑H. Altmann, M. Detmar, C. Halin Winter, J.‑C. Leroux, U. Quitterer, J. Scheuermann, R. Schibli, H. U. Zeilhofer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences, which are focused on within the first two years as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | First identification with Pharmaceutical Sciences; motivation for profiling in the Natural Sciences as a preparation for the specialized studies; sensitization for the duties and the responsibilities of a person with a federal diploma in Pharmacy; information about job opportunities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Introduction to Pharmaceutical Sciences by selected milestones of research and development. Overview on research activities at the Institute of Pharmaceutical Sciences that is focussed on drug delivery and development (from concepts to prototypes). Sensitization for communication skills and information management. Demonstration of job opportunities in community pharmacies, in the hospital, in industry, and in the public sector by experts in the different fields. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handouts for individual lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Interactive teaching | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0011-00L | Drug Seminar The course is reserved for students registered in the Master's programme in Pharmacy or in Pharmaceutical Sciences | 5 credits | 9S | A. Burden, K.‑H. Altmann, M. Detmar, K. Eyer, C. Halin Winter, J. Hall, S.‑D. Krämer, J.‑C. Leroux, C. Müller, V. I. Otto, U. Quitterer, J. Scheuermann, R. Schibli, C. Steuer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. Students work in small groups on a chosen topic, they write a mini-review and present their work on a one day symposium. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The main objectives of this course are: - students develop their scientific reflection (Critical Thinking) and working skills by working independently on a relevant pharmaceutical topic - students gain in-depth knowledge of the topic investigated - students train their scientific writing and presentation skills - students train their ability to plan a project and work in a team | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The Course Drug Seminar takes place during the first 7 weeks of the 1. Master semester. It is a compulsory course of the MSc Pharmacy curriculum and an elective course in the MSc PharmSciences. The course provides a platform for the investigation, presentation and discussion of a topic with relevance to the field of pharmaceutical sciences. During the course, students work in small teams on a topic of their choice and elaborate a written mini-review and an oral presentation. Each team is tutored by a lecturer of the Institute of Pharmaceutical Sciences. The work is mainly based on literature search / review, but may also involve conducting interviews or site visits, if appropriate. The final presentations of all groups will take place in the framework of a dedicated Symposium held in the middle of the semester. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Only for students of MSc Pharmacy and MSc Pharmaceutical Sciences. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0030-00L | Therapeutic Proteins | 3 credits | 3G | C. Halin Winter, D. Neri | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | In this course, various topics related to the development, GMP production and application of therapeutic proteins will be discussed. Furthermore, students will expand their training in pharmaceutical immunology and will be introduced to the basic concepts of pharmaceutical product quality management. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Students know and understand: - basic mechanisms and regulation of the immune response - the pathogenic mechanisms of the most important immune-mediated disorders - the most frequently used expression systems for the production of therapeutic proteins - the use of protein engineering tools for modifying different features of therapeutic proteins - the mechanism of action of selected therapeutic proteins and their application - basic concepts in the GMP production of therapeutic proteins | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course consists of two parts: In a first part, students will complete their training of pharmaceutical immunology (Chapter 13 - 16 Immunobiology VIII textbook). This part particularly focuses on the pathogenic mechanisms of immune-mediated diseases. Deepened knowledge of immunology will be relevant for understanding the mechanism of action of many therapeutic proteins, as well as for understanding one major concern related to the use of protein-based drugs, namely, immunogenicity. The second part focuses on topics related to the development and application of therapeutic proteins, such as protein expression, protein engineering, reducing immunogenicity, and GMP production of therapeutic proteins. Furthermore, selected examples of approved therapeutic proteins will be discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handouts to the lectures will be available for downloading under http://www.pharma.ethz.ch/scripts/index | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | - Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition), Chapters 12-16 - Lecture Handouts - Paper References provided in the Scripts - EMEA Dossier for Humira | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0239-00L | Practical Course in Medicinal Chemistry | 3 credits | 7P | J. Hall, M. Detmar, C. Halin Winter, J. Scheuermann | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course comprises experiments relating to concepts of medicinal chemistry including statistical processing, fitting of experimental data, computer modeling of protein structures, experimental measurement of affinity constants and kinetic dissociation constants for protein ligands. The chemical stability of a drug will be studied. Basic gene cloning and protein expression will be introduced. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of experimental methods in drug discovery and development | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Characterisation of the biophysical and biological properties of drugs. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Original literature | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Requirements: Laboratory course in Pharmaceutical Anaytics; Lecture Medicinal Chemistry I in the same semester or earlier. Safety conceptt: https://chab.ethz.ch/studium/bachelor1.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0830-00L | Pharmaceutical Immunology  | 2 credits | 2G | C. Halin Winter, V. Collado Diaz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Get Students familiar with basic Immunological concepts of pharmaceutical relevance. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Get Students familiar with basic Immunological concepts of pharmaceutical relevance. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Chapters 1 - 11 of the Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition; Garland). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Janeway's ImmunoBiology, by Kenneth Murphy (9th Edition). Paperback [www.garlandscience.com] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 535-0900-00L | Seminars on Drug Discovery and Development | 1 credit | 1K | R. Schibli, K.‑H. Altmann, M. Detmar, K. Eyer, C. Halin Winter, J. Hall, J.‑C. Leroux, U. Quitterer, G. Schneider, H. U. Zeilhofer | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | State-of-the-art information on drug discovery and development by experts from academia and industry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | State-of-the-art information on drug discovery and development. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Seminar series of the Institute of Pharmaceutical Sciences. Experts from academia and industry report on relevant topics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-0509-00L | Current Immunological Research in Zurich | 0 credits | 1K | R. Spörri, M. Detmar, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | none | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1117-00L | Cutting Edge Topics: Immunology and Infection Biology Information for UZH students: Enrolment to this course unit only possible at ETH. No enrolment to module BIO636 at UZH. Please mind the ETH enrolment deadlines for UZH students: Link | 2 credits | 1S | A. Oxenius, B. Becher, C. Halin Winter, M. Kopf, S. R. Leibundgut, C. Münz, L. Tortola, M. van den Broek | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Immunology and infection biology. The specific topics are variable and depend each semester on the list of invited experts. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Current research data (often not yet published) are presented in this seminar series. There is no script and we are not allowed to record or distribute the contents of the seminars. Thus, the ability of students to extract the most relevant points of each seminar is promoted, which is an important skill for the future attendance of scientific meetings. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Often parts of the presented seminars have already been published by the respective speakers and the respective primary research can be retrieved from scientific journals. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||