Kristin Schirmer: Katalogdaten im Frühjahrssemester 2023 |
| Name | Frau Prof. Dr. Kristin Schirmer |
| Adresse | EAWAG Überlandstr. 133 I. f. Biogeochemie/Schadstoffdyn. 8600 Dübendorf SWITZERLAND |
| Telefon | 044 823 52 66 |
| Fax | 044 823 53 11 |
| kristin.schirmer@usys.ethz.ch | |
| Departement | Umweltsystemwissenschaften |
| Beziehung | Titularprofessorin |
| Nummer | Titel | ECTS | Umfang | Dozierende | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 701-1312-00L | Ecotoxicology | 3 KP | 3V | K. Schirmer, E. Janssen | |||||||||||||||||
| Kurzbeschreibung | This course will take up the principles of environmental chemistry and ecotoxicology from the bachelor courses and deepen the understanding on selected topics. Linkages will be made between i) bioavailability and effects, ii) structures of compounds and modes of toxic action, iii) effects over various biological levels, moderated by environmental factors, iv) chemical and biological assessments | ||||||||||||||||||||
| Lernziel | • describe the key processes involved in fate, behavior and the bioaccumulation of (mainly) organic contaminants • demonstrate overview on and understanding of mechanisms of toxicity • relate structures and characteristics of compounds with effects • explain processes in hazard assessment and risk assessment • obtain further insight in integrative approaches in ecotoxicology | ||||||||||||||||||||
| Inhalt | Units 1-4: Interactions of chemicals with the (a)biotic environment - physico-chemical properties - partitioning processes in environmental compartments - chemical analysis and effect directed analysis - partitioning to biological phases - uptake and elimination (Toxicokinetics part 1) - exercise: personal student chemicals and their environmental behavior Units 5-7: Toxicokinetics and Toxicodynamics - toxicokinetic mechanisms: biotransformation and elimination - baseline toxicity, internal concentrations, molecular targets - specific molecular mechanisms of toxic actions – classification - consequences for organism/population function - Exercise: databases and estimation of toxicity Unit 8-10: Toxic effects: from molecular to ecosystems - biological analysis and -omics approaches - level of complexity: molecules–cells–organisms–ecosystems - stress- and adaptive responses - multiple species concept - metal ecotoxicology Unit 11-14: Stressor and exposure scenarios - mixtures and multiple stressors - targets and non-targets - dynamic exposures, time and dose, risk assessment - (inter) national case studies and linkage of learned concepts with approaches in practice - Exercise: linking compounds with modes of toxic action | ||||||||||||||||||||
| Skript | Material will be in the form of copies of lecture slides, selected publications and exercise material. | ||||||||||||||||||||
| Literatur | R.P. Schwarzenbach, P.M. Gschwend, D.M. Imboden, Environmental Organic Chemistry, third edition, Wiley, 2005 Principles of ecotoxicology, CH Walker, RM Sibly, SP Hopkin, DB Peakall, fourth edition, CRC Press, 2012 | ||||||||||||||||||||
| Voraussetzungen / Besonderes | Required: 1. Basics in environmental chemistry 2. Basics in environmental toxicology | ||||||||||||||||||||
| 701-1330-00L | Ecotoxicology Laboratory  | 3 KP | 6P | K. Schirmer, K. Groh, C. vom Berg-Maurer | |||||||||||||||||
| Kurzbeschreibung | This laboratory course enables students to become familiar with state-of-the-art methods and concepts of molecular ecotoxicology. We explore mechanisms of action of chemicals occurring in our freshwaters on fish cells and embryos. The course is organized in theoretical and practical training components, including data evaluation and presentation. Students work both in class and in small groups. | ||||||||||||||||||||
| Lernziel | Molecular methods are crucial for shedding light on mechanisms underlying biological structure and function under normal and stress conditions. The aim of this course it to demonstrate the power of these methods but also their limits and to enable students to appreciate them both in theoretical and practical terms. | ||||||||||||||||||||
| Inhalt | Training comprises designing and carrying out of chemical exposure experiments and assessment of disturbances or defense responses in fish cells and embryos, such as impact on viability, sub-lethal developmental effects, growth, and associated gene or protein expression. Applied techniques include cell/embryo culture, microscopy techniques, polymerase chain reaction, video analysis and statistics. | ||||||||||||||||||||
| Skript | Course material will be provided in the form of background scripts and method protocols. | ||||||||||||||||||||
| Literatur | No particular recommendation. | ||||||||||||||||||||
| Voraussetzungen / Besonderes | Basic knowledge in cell and molecular biology as well as ecotoxicology are required. | ||||||||||||||||||||
| 752-1300-00L | Introduction to Toxicology | 3 KP | 2V | S. J. Sturla, F. Michailidou, K. Schirmer, C. vom Berg-Maurer | |||||||||||||||||
| Kurzbeschreibung | Introduction to how chemical properties and biological interactions govern the disposition and influences of toxicants. | ||||||||||||||||||||
| Lernziel | The objectives are for the student to establish a framework for examining adverse effects resulting from exposures to toxicants by understanding key mechanisms that give rise to toxic responses and disease processes. In the course "Introduction to Toxicology", the competencies of process understanding, system understanding, concept development, data analysis & interpretation and measurement methods are taught, applied and examined. | ||||||||||||||||||||
| Inhalt | This course will introduce mechanisms governing the chemical disposition and biological influences of toxicants. The course is geared toward advanced bachelors students in food science, environmental science, and related disciplines, such as chemistry, biology and pharmaceutical sciences. Examples of topics include: dose-response relationships and risk assessment, absorption, transport, and biotransformation of xenobiotic chemicals; Carcinogenesis; DNA damage, repair, and mutation; Immunotoxicity; Neurotoxicity; and modern toxicity testing strategies. These fundamental concepts in Mechanistic Toxicology will be integrated with examples of toxicants relevant to food, drugs and the environment. | ||||||||||||||||||||
| Literatur | Casarett & Doull's Toxicology, The Basic Science of Poisons. Seventh Edition. Editor: Curtis D. Klaassen, 2008, McGraw-Hill. (available on-line) | ||||||||||||||||||||
| Voraussetzungen / Besonderes | Basic knowledge of organic chemistry and biochemistry is required. | ||||||||||||||||||||
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