Gunnar Jeschke: Catalogue data in Autumn Semester 2023 |
| Name | Prof. Dr. Gunnar Jeschke |
| Field | Electron Paramagnetic Resonance |
| Address | Inst. Mol. Phys. Wiss. ETH Zürich, HCI F 227 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 632 57 02 |
| gunnar.jeschke@phys.chem.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0015-00L | Physical Chemistry | 3 credits | 2V + 1U | G. Jeschke, D. Klose | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Thermodynamic foundations of phase equilibria, intermolecular interactions, and molecular self-assembly; kinetics of chemical reactions and transport processes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course teaches physical-chemical foundations of important processes in living cells and organisms as well as of working techniques in biochemistry and molecular biology. Students learn: 1. Evaluation of chemical equilibria based on chemical potential 2. Interpretation of phase diagrams 3. Which interactions between molecules are important in living cells 4. Why molecules self-organize into aggregates 5. Which physical-chemical basics determine behavior of biomembranes 6. What determines the rate of chemical reactions, in particular also of enzymatically catalyzed reactions 7. What determines the transport rate of matter and heat | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | chemical potential, prediction of the direction of processes, phase equilibria, phase rule, phase diagrams of pure substances, colligative properties, osmosis, dialysis, surface tension, intermolecular interactions, hydrophobic effect, hydrophilic effect and denaturation, amphiphiles, basics of self-association, micelles, packing parameter, double layers, vesicles, membranes, elementary reactions, parallel reactions, consecutive reactions, Eyring theory, enzyme kinetics, diffusion, heat conduction, active transport | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A lecture script is provided | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | In addition to the lecture script, the following two books can be used to gain deeper understanding Marc R. Roussel, A Life Scientist's Guide to Physical Chemistry, Cambridge University Press, 2012 Jacob Israelachvili, Intermoleculr and Surface Forces, Academic Press, 1992 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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| 529-0053-00L | Polymer Physics Methods for Unstructured Biomolecules Does not take place this semester. | 3 credits | 2V | G. Jeschke | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course will provide the "polymer physics view" for the broad area of bio-polymers research. This will include simple and advanced concepts, forming the theoretical "language", critical overview of experimental methods, including the differences in characterization of synthetic and bio-polymers, concepts for modelling conformational ensembles of unstructured bio-polymers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | From the fundamental education point, this course will systematically overview the power of the thermodynamic description, and the interplay between the energy and the entropy for the phenomena that happen at the edge of near equivalence of the thermal energy and the inter-molecular interaction energy. Due to complexity of the bio-molecular interactions, the most successful research approaches in the field of unstructured bio-polymers are based on a clever combination of several structural and spectroscopic methods. Therefore, in this course, there will be a good opportunity to introduce the cross-validation analysis based on complimentary spectroscopic methods, to see examples from real research on different accuracy and different applicability ranges of experimental methods, and to discuss how very different spectroscopic data types can be combined to enhance the understanding of a bio-polymer system. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | - Overview of unstructured bio-polymers and bio-polymers with unstructured domains. - Overview of bio-molecular interactions and interactions to the solvent molecules: types of interactions, energy scales, time scales, length scales. - Overview of spectroscopic methods to characterize the overall conformational properties of unstructured bio-polymers, the strength of their interactions, the peculiarities of their interactions at the atomic level (fluorescence methods, magnetic resonance methods, scattering methods, cross linking methods). - Comparison of these methods in respect to their applicability range, sensitivity range, accuracy, type of the data. - Thermodynamic concepts of bio-polymers, existing models for energy and entropy contributions: Flory theory for polymer chain conformational distribution, reversible gelation theory, electrochemical solvent effects, isotope effects, entropic effects for inhomogeneous distribution of interacting moieties over the polymer chain. - Topics on nucleic acids: double helix vs. single strand stability, conformational ensembles, solvent interactions. - Topics on unstructured proteins and protein domains: entropy contributions, reversible folding, crowding effects, liquid-liquid phase separation, RNA interactions, entropic terms in protein crystallization, entropic terms in reaction constants of interfering binding sites. - Topics of polymer physics of carbohydrates. - Site directed labeling of weakly interacting unstructured bio-molecules, disturbances, selection of reference states, interpretation of the data. - Hybrid methods in studies of bio-polymers, their strength and challenges: accuracy and information content of different methods, ways to combine them, ways to model the bio-polymers based on hybrid spectroscopic data, ways to describe the broad conformational ensembles. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0432-AAL | Physical Chemistry IV: Magnetic Resonance Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 4 credits | 9R | G. Jeschke, M. Ernst | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Theoretical foundations of magnetic resonance (NMR,EPR) and selected applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction to magnetic resonance in isotropic and anisotropic phase. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course gives an introduction to magnetic resonance spectroscopy (NMR and EPR) in liquid, liquid crystalline and solid phase. It starts from a classical description in the framework of the Bloch equations. The implications of chemical exchange are studied and two-dimensional exchange spectroscopy is introduced. An introduction to Fourier spectroscopy in one and two dimensions is given and simple 'pulse trickery' is described. A quantum-mechanical description of magnetic resonance experiments is introduced and the spin Hamiltonian is derived. The chemical shift term as well as the scalar, dipolar and quadrupolar terms are discussed. The product-operator formalism is introduced and various experiments are described, e.g. polarization transfer. Applications in chemistry, biology, physics and medicine, e.g. determination of 3D molecular structure of dissolved molecules, determination of the structure of paramagnetic compounds and imaging (MRI) are presented. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | handed out in the lecture (in english) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | see http://www.ssnmr.ethz.ch/education/PC_IV_Lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0432-00L | Physical Chemistry IV: Magnetic Resonance | 4 credits | 3G | G. Jeschke, M. Ernst | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Theoretical foundations of magnetic resonance (NMR,EPR) and selected applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction to magnetic resonance in isotropic and anisotropic phase. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course gives an introduction to magnetic resonance spectroscopy (NMR and EPR) in liquid, liquid crystalline and solid phase. It starts from a classical description in the framework of the Bloch equations. The implications of chemical exchange are studied and two-dimensional exchange spectroscopy is introduced. An introduction to Fourier spectroscopy in one and two dimensions is given and simple 'pulse trickery' is described. A quantum-mechanical description of magnetic resonance experiments is introduced and the spin Hamiltonian is derived. The chemical shift term as well as the scalar, dipolar and quadrupolar terms are discussed. The product-operator formalism is introduced and various experiments are described, e.g. polarization transfer. Applications in chemistry, biology, physics and medicine, e.g. determination of 3D molecular structure of dissolved molecules, determination of the structure of paramagnetic compounds and imaging (MRI) are presented. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | handed out in the lecture (in english) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | see http://www.ssnmr.ethz.ch/education/PC_IV_Lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0499-00L | Physical Chemistry | 0 credits | 1K | M. Reiher, A. Barnes, G. Jeschke, F. Merkt, J. Richardson, R. Riek, S. Riniker, T. Schmidt, R. Signorell, H. J. Wörner | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Institute-Seminar covering current research Topics in Physical Chemistry | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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