Jeffrey W. Bode: Catalogue data in Autumn Semester 2023 |
| Name | Prof. Dr. Jeffrey W. Bode |
| Field | Synthetic Organic Chemistry |
| Address | Lab. für Organische Chemie ETH Zürich, HCI F 315 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 633 21 03 |
| bode@org.chem.ethz.ch | |
| Department | Chemistry and Applied Biosciences |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0016-00L | BCB III: Organic Chemistry  | 8 credits | 12P | J. W. Bode | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Laboratory course in Organic Chemistry for students of "Biochemisty - Chemical Biology" | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction into basic techniques used in the organic laboratory. Understanding organic reactions through experiments. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Part I: Basic operations such as the isolation, purification, and characterization of organic compounds: distillation, extraction, chromatography, crystallization, IR (UV/1H-NMR)-spectroscopy for the identification of the constitution of organic compounds. Part II: Organic reactions: preparative chemistry. From simple, one-step to multi-step syntheses. The syntheses include classic Organic Chemistry as well as methods widely used in a Chemical Biology context. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | see https://bode.ethz.ch/education/bcb-iii/bcb-iii-lab-course.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | R. K. Müller, R. Keese: "Grundoperationen der präparativen organischen Chemie"; J. Leonard, B. Lygo, G. Procter: "Praxis der Organischen Chemie" (Übersetzung herausgegeben von G. Dyker), VCH, Weinheim, 1996, ISBN 3-527-29411-2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Basisprüfung + BCB I: General Chemistry By enrolling in the laboratory course, students confirm to study all safety information thoroughly and to follow instructions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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| 529-0018-00L | Organic Chemistry for Biochemistry and Chemical Biology | 6 credits | 3G | J. W. Bode | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The synthesis and reactivity of organic molecules plays a crucial role in chemical biology, particularly for the interrogation of biological pathways and phenomena. This course will cover advanced topics in the design and synthesis of organic molecules for applications in biochemistry and chemical biology, with particular emphasis on the mechanistic understanding of these reactions and processes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | After the completion of this lecture, the students will have an understanding of organic chemistry commonly employed in the field of chemical biology, be able to apply these concepts to the design and synthesis of tools for probing biological pathways, and explain the underlying reaction mechanisms of selective reactions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course will discuss past and recent advances in the synthesis of biomolecules, organic chemistry for applications in chemical biology, and the mechanism of relevant reactions. Topics will include chemical ligations, bioorthoganal reactions, photoaffinity probes, photopharmacology, activity based probes, targeted protein degraders, chemical probes for metabolites, fluorescent dyes and imaging, caged biomolecules, conditional activation, site-specific protein modification, and metabolic engineering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture notes and other material relevant for the course will be available online under https://bode.ethz.ch/education.html. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Relevant research articles and review papers will be available in the course and course material. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | This is an advanced organic chemistry course. Prior knowledge of organic synthesis, reactions, and mechanisms is required. Familiarity with biochemistry and biology is recommended. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0241-10L | Selectivity in Organic Synthesis | 6 credits | 3G | J. W. Bode | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Fundamentals of selective organic reactions, including current and historical examples of enantioselectivity, regioselectivity, chemoselectivity. Further aspects include recent developments in catalysis, strategies and tools for selective organic synthesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding and explaining the origin of selectivity in organic synthesis and the application of selective organic reactions to the construction of complex organic and biological molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Fundamental concepts and recent advances for the selective synthesis of complex organic molecules, including natural products, pharmaceuticals, and biological molecules. Key concepts include the development of enantioselective and regioselective catalysts, the identification of new reaction mechanisms and pathways, and technological advances for facilitating the synthesis of organic molecules. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | will be provided in class and online | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Suggesting Textbooks Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0290-00L | Organic Chemistry (Seminar) | 0 credits | 2S | E. M. Carreira, J. W. Bode, H. Wennemers, R. Zenobi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0299-00L | Organic Chemistry | 0 credits | 1.5K | J. W. Bode, E. M. Carreira, P. Chen, K. Lang, B. Morandi, H. Wennemers, R. Zenobi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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