Tatjana Kleele: Katalogdaten im Herbstsemester 2023 |
| Name | Frau Prof. Dr. Tatjana Kleele |
| Lehrgebiet | Mitochondrienbiologie |
| Adresse | Institut für Biochemie ETH Zürich, HPM E 17.2 Otto-Stern-Weg 3 8093 Zürich SWITZERLAND |
| Telefon | +41 44 633 43 12 |
| tatjana.kleele@bc.biol.ethz.ch | |
| Departement | Biologie |
| Beziehung | Assistenzprofessorin |
| Nummer | Titel | ECTS | Umfang | Dozierende | |||||||||||||||||||||||||||||||||||||||||
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| 551-0319-00L | Cellular Biochemistry (Part I) | 3 KP | 2V | U. Kutay, F. Allain, T. Kleele, I. Zemp | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Concepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Structural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes. Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression. | ||||||||||||||||||||||||||||||||||||||||||||
| Skript | Scripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (alicia.smith@bc.biol.ethz.ch) | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Recommended supplementary literature (review articles and selected primary literature) will be provided during the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | To attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English. | ||||||||||||||||||||||||||||||||||||||||||||
Kompetenzen |
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| 551-0336-00L | Methods in Cellular Biochemistry  Number of participants limited to 19. The enrolment is done by the D-BIOL study administration. | 6 KP | 7P | I. Zemp, T. Kleele, V. Korkhov, U. Kutay, T. Michaels, M. Peter | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Students will learn about biochemical approaches to analyze cellular functions. The course consists of practical projects in small groups, lectures and literature discussions. The course concludes with the presentation of results at a poster session. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Students will learn to design, carry out and assess experiments using current biochemical and cell biological strategies to analyze cellular functions in model systems. In particular they will learn novel imaging techniques along with biochemical approaches to understand fundamental cellular pathways. Furthermore, they will learn to assess strengths and limitations of the different approaches and be able to discuss their validity for the analysis of cellular functions. | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Documentation and recommended literature (review articles and selected primary literature) will be provided during the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | This course will be taught in English. | ||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 551-1303-00L | Cellular Biochemistry of Health and Disease | 4 KP | 2S | T. Kleele, V. Korkhov, G. Neurohr, V. Panse, M. Peter, A. E. Smith, F. van Drogen | |||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | During this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies. | ||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Students will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to evaluate, critically discuss and write about scientific articles in the research area of cellular biochemistry, and they will identify open testable research questions. | ||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Guided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications. By the end of the semester, students will formulate their ideas about open testable research questions that extend from the published work. | ||||||||||||||||||||||||||||||||||||||||||||
| Literatur | The literature will be provided during the course | ||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | The course will be taught in English. | ||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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