Annette Oxenius: Catalogue data in Spring Semester 2024 |  |
| Name | Prof. Dr. Annette Oxenius |
| Field | Immunology |
| Address | Institut für Mikrobiologie ETH Zürich, HCI G 401 Vladimir-Prelog-Weg 1-5/10 8093 Zürich SWITZERLAND |
| Telephone | +41 44 632 33 17 |
| aoxenius@micro.biol.ethz.ch | |
| Department | Biology |
| Relationship | Full Professor |
| Number | Title | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-0318-00L | Immunology II | 3 credits | 2V | A. Oxenius, M. Kopf, S. R. Leibundgut, E. Slack, further lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction into the cellular and molecular basis of the immune system and immune responses against diverse pathogens, tumors, transplants, and self (autoimmunity) | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The lectures will provide a detailed understanding: - how innate and adaptive immune responses interact at the cellular and molecular level. - how the immune system recognizes and fights against pathogenic microorganisms including viruses, bacteria, and parasites. - why lymphocytes tolerate self molecules. - about function and dysfunction the intestinal immune system. - immunopathology and inflammatory diseases. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The aim of lecture is to understand: > How pathogens are recognized by the innate immune system > Immune defense against various pathogens > Immunology of the skin, lung and intestines > Tumor immunology > Migration and homing of immune cells > tolerance and autoimmunity > T cell memory | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Presentations of the lecturers are available at the Moodle link | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Recommended: Kuby Immunology (Freeman) | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Competencies |
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| 551-0396-01L | Immunology  Number of participants limited to 50. Prerequisites: Attendance of the concept courses Immunology I (551-0317-00L) and Immunology II (551-0318-00L) The enrolment is done by the D-BIOL study administration. | 6 credits | 7P | A. Oxenius, M. Kopf, D. Latorre, B. Ludewig, N. Pikor, F. Sallusto, M. van den Broek | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This block course teaches a wide selection of practical immunological techniques and offers advanced lectures in selected topics in immunology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of this block course is the acquaintance with a wide spectrum of immunological techniques involving practical experimental work following analysis and interpretation of the experimental data. Along the practical work, advanced lectures in selected topics in immunology, based on the knowledge from the immunology concept course, will be offered. Furthermore, students will have the opportunity to read, interpret and present current papers followed scientific discussions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Praktische Arbeiten: Zellkultur, Isolation hämatopoietische Stammzellen und Differenzierung von Makrophagen und dendritischen Zellen, Aktivierung und Zytokinproduktion durch Makrophagen und dendritische Zellen, 51Cr release assay, VSV Neutralisationsassay, Durchflusszytometrie, Proliferationsexperimente, SEREX, Intrazelluläres Zytokinstaining, Immunhistologie und Fluoreszenzmikroskopie, MACS, Zytokin-Bioassays, Phagozytose, Proteosomale Prozessierung Vertiefende Vorlesungen: Immune responses to pathogens, Vaccination and B cells, Tolerance & Autoimmunity, Antigen processing & presentation, Pattern recognition, NK cells, Generation of (TCR) tg or ko mice, Antigen screening and definition | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script for the course will be available online (the link will be provided in the immunology concept lecture, 551-0318-00L). | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Requirement for the registration for this block course is the attendance of the immunology concept courses 551-0317-00L and 551-0318-00L. Evaluation of achievements is done on an individual basis by each participating lecturer. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 551-0509-00L | Current Immunological Research in Zurich | 0 credits | 1K | R. Spörri, C. Halin Winter, W.‑D. Hardt, M. Kopf, S. R. Leibundgut, A. Oxenius, University lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This monthly meeting is a platform for Zurich-based immunology research groups to present and discuss their ongoing research projects. At each meeting three PhD students or Postdocs from the participating research groups present an ongoing research project in a 30 min seminar followed by a plenary discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of this monthly meeting is to provide further education for master and doctoral students as well as Postdocs in diverse topics of immunology and to give an insight in the related research. Furthermore, this platform fosters the establishment of science- and technology-based interactions between the participating research groups. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Presentation and discussion of current research projects carried out by various immunology-oriented research groups in Zurich. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | none | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1100-00L | Infectious Agents: From Molecular Biology to Disease Number of participants limited to 22. Requires application until 2 weeks before the start of the semester; selected applicants will be notified one week before the first week of lectures. (if you missed the deadline, please come to the first date to see, if there are any slots left) | 4 credits | 2S | W.‑D. Hardt, A. B. Hehl, M. Kopf, S. R. Leibundgut, C. Münz, A. Oxenius, P. Sander, further lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Literature seminar for students at the masters level and PhD students. Introduction to the current research topics in infectious diseases; Introduction to key pathogens which are studied as model organisms in this field; Overview over key research groups in the field of infectious diseases in Zürich. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Working with the current research literature. Getting to know the key pathogens serving as model organisms and the research technologies currently used in infection biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | for each model pathogen (or key technology): 1. introduction to the pathogen 2. Discussion of one current research paper. The paper will be provided by the respective supervisor. He/she will give advice (if required) and guide the respective literature discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Teachers will provide the research papers to be discussed. Students will prepare handouts for the rest of the group for their assigned seminar. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Teachers will provide the research papers to be discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Restricted to max 22 students. Please sign up until two weeks before the beginning of the semester via e-mail to micro_secr@micro.biol.ethz.ch and include the following information: 551-1100-00L; your name, your e-mail address, university/eth, students (specialization, semester), PhD students (research group, member of a PhD program? which program?). The 22 students admitted to this seminar will be selected and informed by e-mail in the week befor the beginning of the semester by W.-D. Hardt. The first seminar date will serve to form groups of students and assign a paper to each group. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 551-1106-00L | Progress Reports in Microbiology and Immunology Students must sign up via secr.micro.biol.ethz.ch | 0 credits | 5S | J. Piel, W.‑D. Hardt, A. Oxenius, J. Vorholt-Zambelli | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Presentation and discussion of current research results in the field of Microbiology and Infection Immunology | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Precise and transparent presentation of research findings in relation to the current literature, critical discussion of experimental data and their interpretation, development and presentation of future research aims | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1118-00L | Cutting Edge Topics: Immunology and Infection Biology II | 2 credits | 2S | A. Oxenius, B. Becher, C. Halin Winter, N. C. Joller, M. Kopf, S. R. Leibundgut, C. Münz, F. Sallusto, C. Schneider, R. Spörri, M. van den Broek, University lecturers | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Weekly seminar about cutting edge topics in immunology and infection biology. Internationally renowned experts present their current research followed by an open discussion. The aim of this course is to confront students with current research topics and with scientific presentation. The course offers the opportunity to gain in depth knowledge about diverse topics which are often only briefly touched in the concept courses and to engage in discussion with experts in the field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Immunology and infection biology. The specific topics are variable and depend each semester on the list of invited experts. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1518-00L | Molecular Mechanisms of Health and Disease | 2 credits | 2G | S. Werner, N. Aceto, M. Kopf, A. Oxenius | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course builds on the Fundamentals in Biology courses that are taught during the first three semesters. Students will be introduced into molecular disease mechanisms with a focus on the immune system and its role in health and disease and on cancer biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | To understand the fundamental developments and functions of immune defense in multicellular organisms. To understand the principles of physical barriers, mechanisms of local and systemic defense pathways, migration and communication of and in between immune cells, the fundamental principles of self versus non-self recognition To understand the molecular and functional differences between a normal cell and a cancer cell To understand the molecular mechanisms underlying cancer development and progression to metastasis, including the role of immune cells, environmental toxins and cancer-promoting viruses To understand how vulnerabilities of cancer cells are exploited for modern cancer therapy | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Powerpoint Slides of the Course | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Cancer chapter of "Alberts, Molecular Biology of the Cell, 6th edition" | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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