Christian Wolfrum: Catalogue data in Spring Semester 2023 |
| Name | Prof. Dr. Christian Wolfrum |
| Field | Translational Nutrition Biology |
| Address | VP Forschung ETH Zürich, HG F 57 Rämistrasse 101 8092 Zürich SWITZERLAND |
| christian.wolfrum@sl.ethz.ch | |
| Department | Health Sciences and Technology |
| Relationship | Full Professor and Vice President of Research |
| Number | Title | ECTS | Hours | Lecturers | |
|---|---|---|---|---|---|
| 376-0006-02L | Laboratory Course in Molecular Biology  This lab course takes place in the 6th semester as standard - please do not take it until then. Exception: Students who are on exchange in the 6th semester can complete the lab in the 4th semester; please contact the departmental exchange coordinator if you wish to do so. | 3 credits | 3P | K. De Bock, O. Bar-Nur, F. von Meyenn, C. Wolfrum | |
| Abstract | Introduction to experimental molecular biology using physiological examples. | ||||
| Learning objective | Practical experience of molecular biology. Learning of fundamental research methods. | ||||
| Content | Protein analysis , cell culture, quantification of RNA. | ||||
| Lecture notes | Ein Skript zum Praktikum wird abgegeben. | ||||
| Prerequisites / Notice | Cell Biology | ||||
| 376-0009-00L | Molecular and Cell Biology in Health and Disease | 6 credits | 5G | C. Wolfrum | |
| Abstract | The course will focus on the biochemical, molecular and cellular mechanisms governing disease development. It will cover different areas building on the courses Molecular Genetics and Cell Biology as well as Biochemistry to develop a conceptual understanding of these processes. | ||||
| Learning objective | Understand the molecular and cellular concepts of disease development based on examples of different diseases and physiological adaptations. Understand the molecular and cellular changes responsible for a selected number of diseases/physiological adaptations. Develop a presentation explaining the molecular and cellular changes responsible for a specific disease/physiological adaptation. | ||||
| Content | 1. linear mechanistic models of pathological processes & collagen and its pathological processes 2. protein diseases - mutations/aggregates 3. enzymes in pathology - enzyme deficiency, drug targets, drug interactions, biomarkers 4. biochemical methods in diagnostics 5. biological membranes - lipid-dependent diseases lipid metabolism, cholesterol metabolism, cholesterol in the nervous system, membrane diseases in the nervous system 6. protein-mediated movement - proteins as motor function, muscle diseases, myotonia, cardiomyophathies 7. cellular communication - principle of hormonal effects, thyroid, beta cell, insulin, diabetes, adipokines 8. hypertension - regulation of blood pressure 9. metabolism - carbohydrate metabolism and related diseases 10. metabolism - hereditary fructose intolerance, glycogen storage disorders 11. disorders of amino acid metabolism, urea cycle, gout 12. systemic regulation metabolism autophagy | ||||
| Literature | Löffler/Petrides: Biochemie und Pathobiochemie. | ||||
| 752-6001-AAL | Introduction to Nutritional Science  Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement. Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit. | 3 credits | 6R | C. Wolfrum, F. von Meyenn | |
| Abstract | This course introduces basic concepts of micro- and macronutrient nutrition. Micronutrients studied include fat-soluble and water-soluble vitamins, minerals and trace elements. Macronutrients include proteins, fat and carbohydrates. Special attention is given to nutrient digestion, bioavailability, metabolism and excretion with some focus on energy metabolism. | ||||
| Learning objective | To introduce the students to the both macro- and micronutrients in relation to food and metabolism. | ||||
| Content | The course is devided into two parts. The lectutres on micronutrients are given by Prof. Zimmermann and the lectures on macronutrients are given by Prof. Wolfrum. Prof. Zimmermann discusses the micronutrients, including fat-soluble vitamins, water-soluble vitamins, minerals and trace elements. Prof. Wolfrum introduces basic nutritional aspects of proteins, fats, carbohydrates and energy metabolism. The nutrients are described in relation to digestion, absorption and metabolism. Special aspects of homeostasis and homeorhesis are emphasized. | ||||
| Literature | Present Knowledge in Nutrition, 10th Edition John W. Erdman Jr. (Editor), Ian A. MacDonald (Editor), Steven H. Zeisel (Editor) ISBN: 978-0-470-95917-6 September 2012 Wiley-Blackwell 1328 Pages | ||||