529-0222-00L Organic Chemistry II
| Semester | Spring Semester 2019 |
| Lecturers | J. W. Bode, B. Morandi |
| Periodicity | yearly recurring course |
| Language of instruction | English |
Courses
| Number | Title | Hours | Lecturers | ||||
|---|---|---|---|---|---|---|---|
| 529-0222-00 V | Organic Chemistry II | 2 hrs |
| J. W. Bode, B. Morandi | |||
| 529-0222-00 U | Organic Chemistry II oder nach Vereinbarung | 1 hrs | J. W. Bode, B. Morandi |
Catalogue data
| Abstract | This course builds on the material learned in Organic Chemistry I or Organic Chemistry II for Biology/Pharmacy Students. Topics include advanced concepts and mechanisms of organic reactions and introductions to pericyclic and organometallic reactions. These topics are combined to the planning and execution of multiple step syntheses of complex molecules. |
| Learning objective | Goals of this course include the a deeper understanding of basic organic reactions and mechanism as well as advanced and catalytic transformations (for example, Mitsunobu reactions, Corey-Chaykovsky epoxidation, Stetter reactions, etc). Reactive intermediates including carbenes and nitrenes are covered, along with methods for their generation and use in complex molecule synthesis. Frontier molecular orbital theory (FMO) is introduced and used to rationalize pericyclic reactions including Diels Alder reactions, cycloadditions, and rearrangements (Cope, Claisen). The basic concepts and key reactions of catalytic organometallic chemistry, which are key methods in modern organic synthesis, and introduced, with an emphasis on their catalytic cycles and elementrary steps. All of these topics are combined in an overview of strategies for complex molecule synthesis, with specific examples from natural product derived molecules used as medicines. |
| Content | Oxidation and reduction of organic compounds, redox netural reactions and rearrangments, advanced transformations of functional groups and reaction mechanismes, kinetic and thermodynamic control of organic reactions, carbenes and nitrenes, frontier molecular orbital theory (FMO), cycloadditions and pericyclic reactions, introduction to organometallic chemistry and catalytic cross couplings, introduction to peptide synthesis and protecting groups, retrosynthetic analysis of complex organic molecules, planning and execution of multi-step reaction. |
| Lecture notes | The lecture notes and additional documents including problem sets are available as PDF files online, without charge. Link: http://www.bode.ethz.ch/education.html |
| Literature | Clayden, Greeves, and Warren. Organic Chemistry, 2nd Edition. Oxford University Press, 2012. |
Performance assessment
| Performance assessment information (valid until the course unit is held again) | |
Performance assessment as a two-semester course together with 529-0221-00L Organic Chemistry I | |
| For programme regulations (Examination block) | Bachelor's Degree Programme in Chemical Engineering 2006; Version 27.03.2018 (Examination Block I) Bachelor's Degree Programme in Chemical Engineering 2018; Version 26.09.2022 (Examination Block I) Bachelor's Degree Programme in Chemistry 2005; Version 27.03.2018 (Examination Block I) Bachelor's Degree Programme in Chemistry 2018; Version 26.09.2022 (Examination Block I) Bachelor's Degree Programme in Interdisciplinary Sciences 2010; Version 27.03.2018 (Examination Block) Bachelor's Degree Programme in Interdisciplinary Sciences 2018; Version 12.07.2022 (Examination Block) |
| ECTS credits | 6 credits |
| Examiners | J. W. Bode, B. Morandi, H. Wennemers |
| Type | session examination |
| Language of examination | German |
| Repetition | The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit. |
| Mode of examination | written 120 minutes |
| Written aids | Keine. |
|
Performance assessment as a semester course
(other programmes)
| |
| ECTS credits | 3 credits |
| Examiners | J. W. Bode, B. Morandi |
| Type | session examination |
| Language of examination | English |
| Repetition | The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit. |
| Mode of examination | written 60 minutes |
| Written aids | keine |
| If the course unit is part of an examination block, the credits are allocated for the successful completion of the whole block. This information can be updated until the beginning of the semester; information on the examination timetable is binding. | |
Learning materials
| No public learning materials available. | |
| Only public learning materials are listed. |
Groups
| No information on groups available. |
Restrictions
| There are no additional restrictions for the registration. |
