551-0140-00L Epigenetics
| Semester | Spring Semester 2020 |
| Lecturers | A. Wutz, U. Grossniklaus, R. Paro, R. Santoro |
| Periodicity | yearly recurring course |
| Language of instruction | English |
Courses
| Number | Title | Hours | Lecturers | ||||
|---|---|---|---|---|---|---|---|
| 551-0140-00 V | Epigenetics | 2 hrs |
| A. Wutz, U. Grossniklaus, R. Paro, R. Santoro |
Catalogue data
| Abstract | Epigenetics studies the inheritance of traits that cannot be attributed to changes in the DNA sequence. The lecture will present an overview of different epigenetic phenomena and provide detailed insight into the underlying molecular mechanisms. The role of epigenetic processes in the development of cancer and other disorders will be discussed. |
| Learning objective | The aim of the course is to gain an understanding of epigenetic mechanisms and their impact on the development of organisms, regenerative processes or manifestation of disease. |
| Content | Topics - historical overview, concepts and comparison Genetics vs. Epigenetics - Biology of chromatin: structure and function, organization in the nucleus and the role of histone modifications in processes like transcription and replication - DNA methylation as an epigenetic modification - Inheritance of epigenetic modifications during cell division: cellular memory - Stability and reversibility of epigenetic modifications: cellular plasticity and stem cells - Genomic imprinting in plants and mammals - X chromosome inactivation and dosis compensation - position effects, paramutations and transvection - RNA-induced gene silencing - The role of epigenetic processes in cancer development or cell aging |
Performance assessment
| Performance assessment information (valid until the course unit is held again) | |
Performance assessment as a semester course | |
| ECTS credits | 4 credits |
| Examiners | A. Wutz, U. Grossniklaus, R. Paro, R. Santoro |
| Type | session examination |
| Language of examination | English |
| Repetition | The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit. |
| Mode of examination | written 120 minutes |
| Written aids | Keine Hilfsmittel zugelassen. |
| This information can be updated until the beginning of the semester; information on the examination timetable is binding. | |
Learning materials
| No public learning materials available. | |
| Only public learning materials are listed. |
Groups
| No information on groups available. |
Restrictions
| There are no additional restrictions for the registration. |
