Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint
Learning objective
Understanding and critical evaluation of current research in transition metal catalysis. Design of mechanistic experiments to elucidate reaction mechanisms. Synthetic relevance of transition metal catalysis. Students will also learn about writing an original research proposal during a workshop.
Content
Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint. Synthetic applications of these reactions. Introduction and application of tools for the elucidation of mechanisms. Selected examples of topics include: C-H activation, C-O activation, C-C activation, redox active ligands, main group redox catalysis, bimetallic catalysis.
Lecture notes
Lecture slides will be provided online. A Handout summarizing important concepts in organometallic and physical organic chemistry will also be provided. Useful references and handouts will also be provided during the workshop.
Primary literature and review articles will be cited during the course.
The following textbooks can provide useful support for the course:
- Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books. - Crabtree R., The Organometallic Chemistry of the Transition Metals, John Wiley & Sons, Inc. - Hartwig J., Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books. - J. P. Collman, L. S. Hegedus, J. R. Norton, R. G. Finke, Principles and Applications of Organotransition Metal Chemistry.
Prerequisites / Notice
Required level: Courses in organic and physical chemistry (kinetics in particular) of the first and second year as well as ACI and III
Competencies
Subject-specific Competencies
Concepts and Theories
assessed
Method-specific Competencies
Analytical Competencies
assessed
Problem-solving
assessed
Personal Competencies
Adaptability and Flexibility
assessed
Creative Thinking
assessed
Critical Thinking
assessed
Performance assessment
Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course