376-0222-00L Exercise Physiology II: Molecular and Cellular Biology of Skeletal Muscle
| Semester | Spring Semester 2024 |
| Lecturers | K. De Bock, O. Bar-Nur, G. D'Hulst |
| Periodicity | yearly recurring course |
| Language of instruction | English |
Courses
| Number | Title | Hours | Lecturers | ||||
|---|---|---|---|---|---|---|---|
| 376-0222-00 V | Exercise Physiology II: Molecular and Cellular Biology of Skeletal Muscle | 2 hrs |
| K. De Bock, O. Bar-Nur, G. D'Hulst |
Catalogue data
| Abstract | Skeletal muscle is an organ with a striking capacity to adapt to a variety of stimuli. It adapts to different modes of exercise training (endurance versus resistance exercise), regenerates upon damage, and loses its function under pathological conditions. This course gives insights into the molecular and cellular processes that control muscle adaptation to training and muscle repair from injury. |
| Learning objective | Students will be able to understand the cellular composition of the muscle and how this affects muscle function. They will analyse and understand how a muscle adapts to a specific stimulus (exercise, injury, pathology), and how these processes are coordinated on a cellular and molecular level. They will learn the genetic basis of muscle disorders and obtain an overview on current efforts to develop new curative treatments for muscle diseases. Finally, will acquire skills to analyse and interpret current scientific efforts in the field, and translate the implications of research findings for training adaptations. |
| Content | - Adaptations to endurance training - Adaptations to resistance training - Muscle regeneration (focus on muscle stem cells) - Muscle regeneration (focus on the role of stromal cells: vasculature, inflammation, FAPs,…) - Regulation of muscle insulin sensitivity - Muscle memory - Muscle insulin sensitivity and exercise - Muscle fiber typology and training optimization - Dietary approaches to optimize exercise training adaptations - How do elites train? (Or Concurrent training) - Stem cell biology and cell-based therapies for muscle diseases - Myogenic regulatory factors and their roles in muscle regeneration - Genetic basis of muscle diseases - Gene therapy and genome engineering approaches to treat muscle diseases |
| Prerequisites / Notice | - Excercise Physiology I (376-0207-00) |
Performance assessment
| Performance assessment information (valid until the course unit is held again) | |
Performance assessment as a semester course | |
| ECTS credits | 3 credits |
| Examiners | K. De Bock, O. Bar-Nur, G. D'Hulst |
| Type | session examination |
| Language of examination | English |
| Repetition | The performance assessment is offered every session. Repetition possible without re-enrolling for the course unit. |
| Mode of examination | written 90 minutes |
| Written aids | None |
| Digital exam | The exam takes place on devices provided by ETH Zurich. |
| This information can be updated until the beginning of the semester; information on the examination timetable is binding. | |
Learning materials
| No public learning materials available. | |
| Only public learning materials are listed. |
Groups
| No information on groups available. |
Restrictions
| There are no additional restrictions for the registration. |
