Toxicokinetic and toxicodynamic aspects of xenobiotic interactions with cellular structures and mechanisms. Toxic responses at the level of organs (immune-, neuro-, reproductive and genotoxicity) and organisms. Introduction into developmental toxicology and ecotoxicology.
Learning objective
Understanding of the impact of chemicals on biological systems; evaluation of the effects from different biomedical perspectives.
Content
Explanation of important interactions between xeniobiotic chemicals and cellular structures such as membranes, enzymes, and nucleic acids. Relevance of intake, distribution, excretion, and biochemical transformation processes. Relevance of mixtures. Explanation of important modes of toxic action such as immuno toxicity, neurotoxicity, reproduction toxicity, genotoxicity based on examples of certain xenobiotics and their effects on important organs.
Lecture notes
Course material will be handed out as the lectures progress
Literature
Textbooks of pharmacology and toxicology (cf. list in course material)
Prerequisites / Notice
Educational basis: basic chemistry, biology and biochemistry
Performance assessment
Performance assessment information (valid until the course unit is held again)
Performance assessment as a semester course