Introduction to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems.
Learning objective
The aim of our course is to introduce the students to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. Emphasis is given to: • Establishment of nuclear identity and nuclear-cytoplasmic communication • Reorganization of the nucleus in aging • Animal cells during the generation of cell diversity and neuronal differentiation
By the end of the course, based on lectures, literature reading and practical lab work, the students will be able to formulate open questions concerning the function of the nucleus. Thus, the students will know about the mechanisms and consequences of nuclear-cytoplasmic compartmentalization, DNA clustering in the nucleus and cytoplasm during cell divisions and aging.
Content
During this block-course, the students will - learn how organelles establish and maintain identity with a focus on the nucleus - discover the evolutionary and functional plasticity of the nucleus - design, apply, evaluate and compare experimental strategies
Students - in groups of 2 or max. 3 - will be integrated into a research project connected to the subject of the course, within one of the participating research groups.
Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background.
Lecture notes
About 1 week before course start you will be invited to express your preference for a practical lab project on the course moodle site. Optional papers linked to the projects shall support you in that choice. They can also serve as framework orientation for the practical parts of this block course.
Literature
Documentation and recommended literature (review articles) will be provided during the course.
Competencies
Subject-specific Competencies
Concepts and Theories
assessed
Techniques and Technologies
assessed
Method-specific Competencies
Analytical Competencies
assessed
Decision-making
assessed
Problem-solving
assessed
Project Management
fostered
Social Competencies
Communication
assessed
Cooperation and Teamwork
assessed
Personal Competencies
Adaptability and Flexibility
fostered
Creative Thinking
fostered
Critical Thinking
assessed
Integrity and Work Ethics
fostered
Self-awareness and Self-reflection
fostered
Performance assessment
Performance assessment information (valid until the course unit is held again)
Repetition only possible after re-enrolling for the course unit.
Additional information on mode of examination
Only the main examiner is listed above, the additional examiners are the other lecturers of the course.
Students are obliged to be present throughout the block course. Cancellation: If you have to deregister from a course that has been assigned to you (just emergency reasons), please notify in written the course coordinator at least four weeks before the course starts, for courses in the 1st quarter, a cancellation period of one week applies. The study secretariat D-BIOL must also be informed (email CC to studies@biol.ethz.ch) so that the enrollment is deleted. Otherwise the course is considered as "failed".