Search result: Catalogue data in Autumn Semester 2023
Biochemistry - Chemical Biology Master  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Core Subjects and Compensatory Courses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Core Subjects | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0733-02L | Chemical Biology and Synthetic Biochemistry | O | 6 credits | 3G | K. Lang, M. Fottner | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Overview of modern chemical biology and synthetic biochemistry techniques, focussed on protein modification and labeling and on methods to endow proteins with novel functionalities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | After taking this course, students should be capable of the following: A) Recall different possibilities for modifying proteins in vitro and in vivo and their applications in a biological context, B) Understand the chemical and biochemical consequences of modifications and assess the different reaction possibilities in the context of in vivo - in vitro, C) Critically analyze and assess current chemical biology articles D) Question the approaches learned and apply them to new biological problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | principles of protein labeling and protein modification (fluorescent proteins, enzyme-mediated labeling, bioorthogonal chemistries) advanced genetic code expansion methods (amber suppression, orthogonal ribosomes, unnatural base pairs, genome engineering and genome editing) directed evolution and protein engineering chemical biology of ubiquitin and targeted protein degradation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script will not be handed out. Handouts to the lecture will be provided through moodle. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Citations from the original literature relevant to the individual lectures will be assigned during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Knowledge provided in the bachelor lectures 'Nucleic Acids and Carbohydrates' and 'Proteins and Lipids' is assumed for this lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0240-00L | Chemical Biology - Peptides | O | 6 credits | 3G | H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | An advanced course on the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Citations from the original literature relevant to the individual lectures will be assigned weekly. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0241-10L | Selectivity in Organic Synthesis | O | 6 credits | 3G | J. W. Bode | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Fundamentals of selective organic reactions, including current and historical examples of enantioselectivity, regioselectivity, chemoselectivity. Further aspects include recent developments in catalysis, strategies and tools for selective organic synthesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding and explaining the origin of selectivity in organic synthesis and the application of selective organic reactions to the construction of complex organic and biological molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Fundamental concepts and recent advances for the selective synthesis of complex organic molecules, including natural products, pharmaceuticals, and biological molecules. Key concepts include the development of enantioselective and regioselective catalysts, the identification of new reaction mechanisms and pathways, and technological advances for facilitating the synthesis of organic molecules. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | will be provided in class and online | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Suggesting Textbooks Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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