Search result: Catalogue data in Autumn Semester 2024
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 ElectivesStudents are free to choose from a range of D-CHAB chemistry courses appropriate to their level of study (please note admission requirements). In case of doubt, contact the student administration. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inorganic Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0141-00L | Physical Methods for Inorganic Chemistry | W | 6 credits | 3G | M. D. Wörle, D. Günther, J. Koch, R. Verel | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction into the important methods for structural analysis (solid state NMR), crystal structure analysis and surface analysis techniques and their applications | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge in solid state NMR, crystal structure analysis and surface analytical techniques relevant for inorganic materials | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | This lecture course consists of three parts 1) Solid-state NMR 2) Surface and direct solid analysis 3) Crystal structure anaylsis. Most important fundamentals of the individual methods will be presented and details will be explained on most relevant inorganic applications | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Will be given during the lectures | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Organic Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0243-01L | Transition Metal Catalysis: From Mechanisms to Applications | W | 6 credits | 3G | B. Morandi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding and critical evaluation of current research in transition metal catalysis. Design of mechanistic experiments to elucidate reaction mechanisms. Synthetic relevance of transition metal catalysis. Students will also learn about writing an original research proposal during a workshop. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint. Synthetic applications of these reactions. Introduction and application of tools for the elucidation of mechanisms. Selected examples of topics include: C-H activation, C-O activation, C-C activation, redox active ligands, main group redox catalysis, bimetallic catalysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture slides will be provided online. A Handout summarizing important concepts in organometallic and physical organic chemistry will also be provided. Useful references and handouts will also be provided during the workshop. Slides will be uploaded 1-2 days before each lecture on http://morandi.ethz.ch/education.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Primary literature and review articles will be cited during the course. The following textbooks can provide useful support for the course: - Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books. - Crabtree R., The Organometallic Chemistry of the Transition Metals, John Wiley & Sons, Inc. - Hartwig J., Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books. - J. P. Collman, L. S. Hegedus, J. R. Norton, R. G. Finke, Principles and Applications of Organotransition Metal Chemistry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Required level: Courses in organic and physical chemistry (kinetics in particular) of the first and second year as well as ACI and III | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0233-01L | Organic Synthesis: Methods and Strategies | W | 6 credits | 3G | E. M. Carreira | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The complex relation between structural analysis, methods leading to desired transformations, and insight into reaction mechanisms is exemplified. Relations between retrosynthetic analysis of target structures, synthetic methods and their combination in a synthetic strategy. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Extension and deepening of the knowledge in organic synthesis and the principles of structure and reactivity. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Concepts of the planning of organic synthesis (strategy and tactics), retrosynthetic analysis. Structure-reactivity relation in the context of the synthesis of complex molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, Wiley-VCH 1996. K. C. Nicolaou, S. A. Snyder, Classics in Total Synthesis II, Wiley-VCH 2003. K. C. Nicolaou, J. Chen, Classics in Total Synthesis III, Wiley-VCH 2011. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | OC I-IV | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0241-10L | Selectivity in Organic Synthesis | W | 6 credits | 3G | J. W. Bode | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Fundamentals of selective organic reactions, including current and historical examples of enantioselectivity, regioselectivity, chemoselectivity. Further aspects include recent developments in catalysis, strategies and tools for selective organic synthesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding and explaining the origin of selectivity in organic synthesis and the application of selective organic reactions to the construction of complex organic and biological molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Fundamental concepts and recent advances for the selective synthesis of complex organic molecules, including natural products, pharmaceuticals, and biological molecules. Key concepts include the development of enantioselective and regioselective catalysts, the identification of new reaction mechanisms and pathways, and technological advances for facilitating the synthesis of organic molecules. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | will be provided in class and online | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Suggesting Textbooks Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0240-00L | Chemical Biology - Peptides | W | 6 credits | 3G | H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | An advanced course on the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Citations from the original literature relevant to the individual lectures will be assigned weekly. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0731-00L | Nucleic Acids and Carbohydrates Note for BSc Biology students: Only one of the two concept courses 529-0731-00 Nucleic Acids and Carbohydrates (autumn semester) or 529-0732-00 Proteins and Lipids (spring semester) can be counted for the Bachelor's degree. | W | 6 credits | 3G | M. Frei, P. A. Kast, K. Lang, B. M. Lewandowski, H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | No script; illustrations from the original literature relevant to the individual lectures will be provided weekly (typically as handouts downloadable from the Moodle server). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Mainly based on original literature, a detailed list will be distributed during the lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Physical Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0433-01L | Advanced Physical Chemistry: Statistical Thermodynamics | W | 6 credits | 3G | R. Riek, J. Richardson | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction to statistical mechanics and thermodynamics. Prediction of thermodynamic and kinetic properties from molecular data. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction to statistical mechanics and thermodynamics. Prediction of thermodynamic and kinetic properties from molecular data. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Basics of statistical mechanics and thermodynamics of classical and quantum systems. Concept of ensembles, microcanonical and canonical ensembles, ergodic theorem. Molecular and canonical partition functions and their connection with classical thermodynamics. Quantum statistics. Translational, rotational, vibrational, electronic and nuclear spin partition functions of gases. Determination of the equilibrium constants and (transition-state theory) rates of gas phase reactions. Description of ideal gases and ideal crystals. Lattice models, mixing entropy of polymers, and entropic elasticity. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | See homepage of the lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | See homepage of the lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Chemical Thermodynamics, Reaction Kinetics, Molecular Quantum Mechanics and Spectroscopy; Mathematical Foundations (Analysis, Combinatorial Relations, Integral and Differential Calculus) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0027-00L | Advanced Magnetic Resonance - Solid State NMR Does not take place this semester. | W | 6 credits | 3G | M. Ernst | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course is for advanced students and introduces and discusses the theoretical foundations of solid-state nuclear magnetic resonance (NMR). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of the course is to familiarize the students with the basic concepts of modern high-resolution solid-state NMR. Starting from the mathematical description of spin dynamics, important building blocks for multi-dimensional experiments are discussed to allow students a better understanding of modern solid-state NMR experiments. Particular emphasis is given to achiving high spectral resolution. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The basic principles of NMR in solids will be introduced. After the discussion of basic tools to describe NMR experiments, basic methods and experiments will be discussed, e.g., magic-angle spinning, cross polarization, decoupling, and recoupling experiments. Such basic building blocks allow a tailoring of the effective Hamiltonian to the needs of the experiment. These basic building blocks can then be combined in different ways to obtain spectra that contain the desired information. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script which covers the topics will be distributed in the lecture and will be accessible through the web page http://www.ssnmr.ethz.ch/education/ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisite: A basic knowledge of NMR, e.g. as covered in the Lecture Physical Chemistry IV, or the book by Malcolm Levitt. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0130-00L | Advanced Magnetic Resonance - DNP Instrumentation and Applications Does not take place this semester. | W | 6 credits | 3G | A. Barnes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course is for advanced students and covers selected topics from magnetic resonance spectroscopy. The following topics will be covered: •DNP theory & instrumentation •Microwave theory & technology •Biological applications of solid-state DNP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course aims at enabling students to understand the key theoretical points of DNP and to design DNP experiments. Students will be familiarized with the structure of the state-of-the-art DNP instrumentation. Students will be also informed about the technological challenges towards the development of advanced instrumentation for the future DNP experiments. A special focus will be given in the technology of microwave source. Furthermore, students will become familiar with pulse sequences used in biomolecular applications and understand how they are constructed. Students will be able to identify the strengths and weaknesses of biomolecular DNP and how to design DNP experiments for biological applications including sample preparation and choice of NMR experiment and related parameters. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course is separated in three well separated parts. The first part will cover DNP concept and mechanisms, while a special focus will be given in DNP instrumentation, such as MAS technology, and the NMR probe. Several details will be also presented on the development high field NMR magnet. The second part of the course is dedicated to the microwave theory and technology. This part starts with an introduction of the two different types of microwave sources, such as the solid-state devices and vacuum tubes, which are extensively used in DNP and EPR spectroscopy. A special focus will be given to the vacuum tube’s theory and technology. In this context, the Maxwell equations and the propagation of the transverse electric and transverse magnetic modes in circular waveguides will be taught. This material will be the basis for understanding the resonance theory and the fundamentals of the microwave’s generation in vacuum tubes. Based on the theoretical background gained in the previous lectures it will be possible to understand the operation principle of the slow wave devices, such as Klystron, Traveling Wave Tube (TWT), Backward Wave Oscillator (BWO) and Surface Wave Structure (SWS), as well as, the fast wave devices, such as gyro-devices, Free Electron Laser, etc. Finally, some details on the structure of a real DNP gyrotron will be presented. The third part of the course will cover CPMAS and homonuclear and heteronuclear recoupling schemes and their use in correlation spectroscopy for structure and molecular interaction determination. Sample preparation with particular emphasis of glassing agents and their relationship to DNP enhancements will be discussed. Resolution under DNP including a discussion about inhomogeneous and homogeneous broadening at cryogenic temperatures. Methods for circumventing low resolution at cryogenic temperatures will be discussed including site specific isotope labeling, bio-orthogonal labeling and site specific radical labeling/targeting. Concepts around the role of spin diffusion in DNP, direct and indirect DNP, paramagnetic broadening, longitudinal T1 and methyl quenching in biological NMR will also be discussed. These concepts will then be tied together through discussions of biomolecular applications of solid-state DNP including membrane proteins, in-cell DNP and viruses. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script which covers the topics will be accessible through the course Moodle | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisite: A basic knowledge of Magnetic Resonance, e.g. as covered in the Lecture Physical Chemistry IV, or the book "Spin Dynamics" by Malcolm Levitt. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0026-00L | Advanced Magnetic Resonance - Biological Magnetic Resonance | W | 6 credits | 3G | G. Jeschke, R. Riek | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course is for advanced students and covers selected topics from magnetic resonance spectroscopy. It is concerned with inference of structure and dynamics of proteins and their complexes from data obtained by EPR and liquid-state NMR experiments. The special focus is on multi-state and ensemble modelling. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course enables students to design experimental strategies for characterization of structure and dynamics of proteins whose flexibility is relevant for their function. Students understand the spin dynamics that encodes sidechain and backbone motion as well as distance information into signals measured by magnetic resonance experiments. They learn to solve the inverse problem of inferring dynamics parameters and distances from the experimental results. They acquire skills in modelling protein ensemble structure from constraints derived by analyzing magnetic resonance data. Students are aware of the complications introduced by the use of spin labels in such experiments and learn how to include such labels in modelling. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | • Nitroxide spin labels, their interaction with the environment, and influence of their dynamics on EPR line shapes • Contributions to electron spin decoherence and ways to improve resolution in pulsed EPR • Measurement of electron-electron dipole-dipole interaction and conversion of the primary data to distance distributions • Modelling of spin labels by rotamer libraries • Ensemble modelling with distance distributions • Liquid-state NMR experiments for assessing protein structure and dynamics • Assignment of NMR signals for proteins • Theory of the nuclear Overhauser effect (NOE) • Ensemble modelling with exact NOE constraints • Multistate structure calculation and analysis • Further constraints on protein structure and dynamics from NMR experiments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script, which covers the topics, will be accessible through the course Moodle | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | A basic knowledge of magnetic resonance, e.g. as covered in the lecture course Physical Chemistry IV or in the book "Spin Dynamics" by Malcolm Levitt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Analytical Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0043-01L | Analytical Strategy | W | 6 credits | 3G | R. Zenobi, S. Giannoukos, D. Günther | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Problem-oriented development of analytical strategies and solutions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Ability to create solutions for particular analytical problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Individual development of strategies for the optimal application of chemical, biochemical, and physico-chemical methods in analytical chemistry solving predefined problems. Experts from industry and administration present particular problems in their field of activity. Principles of sampling. Design and application of microanalytical systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Copies of problem sets and solutions will be distributed free fo charge | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisites: 529-0051-00 "Analytical Chemistry I (3. Semester)" 529-0058-00 "Analytical Chemistry II (4. Semester)" (or equivalent) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Biological Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0733-02L | Chemical Biology and Synthetic Biochemistry | W | 6 credits | 3G | K. Lang, M. Fottner | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Overview of modern chemical biology and synthetic biochemistry techniques, focussed on protein modification and labeling and on methods to endow proteins with novel functionalities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | After taking this course, students should be capable of the following: A) Recall different possibilities for modifying proteins in vitro and in vivo and their applications in a biological context, B) Understand the chemical and biochemical consequences of modifications and assess the different reaction possibilities in the context of in vivo - in vitro, C) Critically analyze and assess current chemical biology articles D) Question the approaches learned and apply them to new biological problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | principles of protein labeling and protein modification (fluorescent proteins, enzyme-mediated labeling, bioorthogonal chemistries) advanced genetic code expansion methods (amber suppression, orthogonal ribosomes, unnatural base pairs, genome engineering and genome editing) directed evolution and protein engineering chemical biology of ubiquitin and targeted protein degradation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script will not be handed out. Handouts to the lecture will be provided through moodle. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Citations from the original literature relevant to the individual lectures will be assigned during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Knowledge provided in the bachelor lectures 'Nucleic Acids and Carbohydrates' and 'Proteins and Lipids' is assumed for this lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Chemical Aspects of Energy | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0209-00L | Renewable Energy Technologies | W | 4 credits | 3G | A. Bardow, E. Casati | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The course covers the key concepts and aspects involved in: (i) the economics of renewable energy and its integration in the energy system, (ii) the engineering of prominent renewable energy technologies (solar, wind, hydro, geothermal and bioenergy), and (iii) energy storage, renewable transport and renewable heating & cooling. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Students learn the potential and limitations of renewable energy technologies and their contribution towards sustainable energy utilization. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture Notes containing copies of the presented slides. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Prerequisite: strong background on the fundamentals of engineering thermodynamics, equivalent to the material taught in the courses Thermodynamics I, II, and III of D-MAVT. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Chemical Crystallography | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0029-01L | Structure Determination | W | 6 credits | 3G | M. D. Wörle, N. Trapp | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Advanced X-ray crystal structure analysis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | To gain a deeper understanding of crystal structure determination principles and practice by X-ray diffraction and the evaluation of results. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Review of principles of diffraction and instrumentation, unit cells, lattices, and symmetry. Inorganic structural chemistry: sphere packings, ionic crystals, covalent networks, intermetallic compounds. Overview of powder diffraction and application of crystal chemistry for structure analysis of polycrystalline phases. Working safely with X-rays, crystal growth, selection and mounting, data collection strategies, data reduction, corrections for absorption, extinction and Lp, advanced structure solution theory and techniques: Patterson function, heavy atom technique, Fourier methods, direct methods. Structure modeling and refinement, disorder, twinning, false symmetry, interpretation of anisotropic shift parameters. Determination of absolute configuration, interpretation of results and scope of chemically useful information, validation and publication of results, critical evaluation of published crystal structures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Information and exercise sheets will be distributed in loose form. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Main references (1) W. Massa, "Crystal Structure Determination", 2nd Ed., 2004, Springer Verlag. (2) J.D. Dunitz, "X-ray Analysis and the Structure of Organic Molecules", 1995, Verlag HCA. Additional literature (3) C. Hammond, "The Basics of Crystallography and Diffraction", 2nd Ed., 2001, International Union of Crystallography Texts on Crystallography 5, Oxford University Press. (4) J.P. Glusker, M. Lewis & M. Rossi, "Crystal Structure Analysis for Chemists and Biologists", 1994, VCH Publishers. (5) D. Blow, "Outline of Crystallography for Biologists", 2002 Oxford University Press. (6) D. Schwarzenbach, "Kristallographie", 2001, Springer Verlag. (7) C. Giacovazzo, H.L. Monaco, G. Artioli, D. Viterbo, G. Ferraris, G. Gilli, G. Zanotti & M. Catti, Fundamentals of Crystallography", edited by C. Giacovazzo, 2nd Ed., 2002, International Union of Crystallography Texts on Crystallography 7, Oxford University Press. (8) W. Clegg, A.J. Blake, R.O. Gould & P. Main, "Crystal Structure Analysis - Principles and Practice", edited by W. Clegg, 2001, International Union of Crystallography Texts on Crystallography 6, Oxford University Press. (9) J.P. Glusker & K.N. Trueblood, "Crystal Structure Analysis - A Primer", 2nd Ed., 1985, Oxford University Press. (10) G. H. Stout, L. H. Jensen: X-Ray Structure Determination, J. Wiley & Sons, 1989. (11) M. M. Woolfson: X-Ray Crystallography, Cambridge University Press, 1970. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Students will conduct the computational exercises and examples of structure solution and refinement on personal computers. Prerequisite: Principles of Crystal Structure Determination (529-0039-00L). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Technology | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 636-0108-00L | Biological Engineering and Biotechnology | W | 4 credits | 3V | M. Fussenegger | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handout during the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0003-01L | Advanced Quantum Chemistry | W | 6 credits | 3G | M. Reiher, T. Weymuth | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Advanced, but fundamental topics central to the understanding of theory in chemistry and for solving actual chemical problems with a computer. Examples are: * Operators derived from principles of relativistic quantum mechanics * Relativistic effects + methods of relativistic quantum chemistry * Open-shell molecules + spin-density functional theory * New electron-correlation theories | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of the course is to provide an in-depth knowledge of theory and method development in theoretical chemistry. It will be shown that this is necessary in order to be able to solve actual chemical problems on a computer with quantum chemical methods. The relativistic re-derivation of all concepts known from (nonrelativistic) quantum mechanics and quantum-chemistry lectures will finally explain the form of all operators in the molecular Hamiltonian - usually postulated rather than deduced. From this, we derive operators needed for molecular spectroscopy (like those required by magnetic resonance spectroscopy). Implications of other assumptions in standard non-relativistic quantum chemistry shall be analyzed and understood, too. Examples are the Born-Oppenheimer approximation and the expansion of the electronic wave function in a set of pre-defined many-electron basis functions (Slater determinants). Overcoming these concepts, which are so natural to the theory of chemistry, will provide deeper insights into many-particle quantum mechanics. Also revisiting the workhorse of quantum chemistry, namely density functional theory, with an emphasis on open-shell electronic structures (radicals, transition-metal complexes) will contribute to this endeavor. It will be shown how these insights allow us to make more accurate predictions in chemistry in practice - at the frontier of research in theoretical chemistry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | 1) Introductory lecture: basics of quantum mechanics and quantum chemistry 2) Einstein's special theory of relativity and the (classical) electromagnetic interaction of two charged particles 3) Klein-Gordon and Dirac equation; the Dirac hydrogen atom 4) Numerical methods based on the Dirac-Fock-Coulomb Hamiltonian, two-component and scalar relativistic Hamiltonians 5) Response theory and molecular properties, derivation of property operators, Breit-Pauli-Hamiltonian 6) Relativistic effects in chemistry and the emergence of spin 7) Spin in density functional theory 8) New electron-correlation theories: Tensor network and matrix product states, the density matrix renormalization group | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A set of detailed lecture notes will be provided, which will cover the whole course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | 1) M. Reiher, A. Wolf, Relativistic Quantum Chemistry, Wiley-VCH, 2014, 2nd edition 2) F. Schwabl: Quantenmechanik für Fortgeschrittene (QM II), Springer-Verlag, 1997 [english version available: F. Schwabl, Advanced Quantum Mechanics] 3) R. McWeeny: Methods of Molecular Quantum Mechanics, Academic Press, 1992 4) C. R. Jacob, M. Reiher, Spin in Density-Functional Theory, Int. J. Quantum Chem. 112 (2012) 3661 http://onlinelibrary.wiley.com/doi/10.1002/qua.24309/abstract 5) A. Baiardi, M. Reiher, The density matrix renormalization group in chemistry and molecular physics: Recent developments and new challenges, J. Chem. Phys. 152, 040903 (2020) https://doi.org/10.1063/1.5129672 Note also the standard textbooks: A) A. Szabo, N.S. Ostlund. Verlag, Dover Publications B) I. N. Levine, Quantum Chemistry, Pearson C) T. Helgaker, P. Jorgensen, J. Olsen: Molecular Electronic-Structure Theory, Wiley, 2000 D) R.G. Parr, W. Yang: Density-Functional Theory of Atoms and Molecules, Oxford University Press, 1994 E) R.M. Dreizler, E.K.U. Gross: Density Functional Theory, Springer-Verlag, 1990 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Strongly recommended (preparatory) courses are: quantum mechanics and quantum chemistry | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 529-0004-01L | Classical Simulation of (Bio)Molecular Systems | W | 6 credits | 4G | P. H. Hünenberger, J. Dolenc, S. Riniker | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Molecular models, classical force fields, configuration sampling, molecular dynamics simulation, boundary conditions, electrostatic interactions, analysis of trajectories, free-energy calculations, structure refinement, applications in chemistry and biology. Exercises: hands-on computer exercises for learning progressively how to perform an analyze classical simulations (using the package GROMOS). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction to classical (atomistic) computer simulation of (bio)molecular systems, development of skills to carry out and interpret these simulations. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Molecular models, classical force fields, configuration sampling, molecular dynamics simulation, boundary conditions, electrostatic interactions, analysis of trajectories, free-energy calculations, structure refinement, applications in chemistry and biology. Exercises: hands-on computer exercises for learning progressively how to perform an analyze classical simulations (using the package GROMOS). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | The powerpoint slides of the lectures will be made available weekly on the website in pdf format (on the day preceding each lecture). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | See: www.csms.ethz.ch/education/CSBMS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Since the exercises on the computer do convey and test essentially different skills than those being conveyed during the lectures and tested at the oral exam, the results of the exercises are taken into account when evaluating the results of the exam (learning component, possible bonus of up to 0.25 points on the exam mark). For more information about the lecture: www.csms.ethz.ch/education/CSBMS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| Material Science | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 327-0703-00L | Electron and Ion Microscopy in Material Science Former title: Electron Microscopy in Material Science | W | 4 credits | 2V + 2U | S. Gerstl, R. Erni, F. Gramm, A. Käch, F. Krumeich, K. Kunze | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | A comprehensive understanding of the interaction of electrons and ions with condensed matter and details on the instrumentation and methods designed to use these probes in the structural and chemical analysis of various materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | A comprehensive understanding of the interaction of electrons and ions with condensed matter and details on the instrumentation and methods designed to use these probes in the structural and chemical analysis of various materials. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | This course provides a general introduction into electron- and ion- microscopy of organic and inorganic materials. In the first part, the basics of transmission- and scanning electron microscopy are presented. The second part includes the most important aspects of specimen preparation, imaging and image processing. In the third part, focused ion-beam and atom probe microscopes are presented. Throughout the semester, various applications in materials science, solid state physics, structural biology, structural geology, and structural chemistry will be reported. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | will be distributed in English | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Goodhew, Humphreys, Beanland: Electron Microscopy and Analysis, 3rd. Ed., CRC Press, 2000 Thomas, Gemming: Analytical Transmission Electron Microscopy - An Introduction for Operators, Springer, Berlin, 2014 Thomas, Gemming: Analytische Transmissionselektronenmikroskopie: Eine Einführung für den Praktiker, Springer, Berlin, 2013 Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996 Reimer, Kohl: Transmission Electron Microscopy, 5th Ed., Berlin, 2008 Erni: Aberration-corrected imaging in transmission electron microscopy, Imperial College Press (2010, and 2nd ed. 2015) Larson, David: Local Electrode Atom Probe Tomography. Springer Series in Materials Science, New York (2013). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 402-0468-15L | Nanomaterials for Photonic Devices | W | 6 credits | 2V + 1U | R. Grange, E. Bailly, R. Chapman, V. Falcone, A. Morandi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The lecture describes various nanomaterials (semiconductor, metal, dielectric, carbon-based...) for photonic applications (optoelectronics, plasmonics, photonic integrated circuits, ordered and disordered structures...). It starts with concepts of light-matter interactions, fabrication and characterization, the description of the properties and the state-of-the-art applications and devices. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The students will acquire theoretical and experimental knowledge about the different types of nanomaterials (semiconductors, metals, dielectric, carbon-based, ...) and their uses as building blocks for advanced applications in photonics (optoelectronics, plasmonics, photonic crystal, ...). Together with the exercises, the students will learn (1) to read, summarize and discuss scientific articles related to the lecture, (2) to estimate order of magnitudes with calculations using the theory seen during the lecture, (3) to prepare a short oral presentation and report about one topic related to the lecture, and (4) to imagine an original photonic device. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | 1. Introduction to nanophotonics 2. Wave physics for nanophotonics 3. Characterization of nanomaterials 4. Semiconductors 5. Nonlinear crystals 6. Photonic integrated circuits 7. Optical quantum devices 8. Plasmonics 9. Metasurfaces 10. Graphene & 2D Materials 11. Nanocomposites | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Slides and book chapter will be available for downloading | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | References will be given during the lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Basics of solid-state physics (i.e. energy bands) can help | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 327-2145-00L | Advanced Polymer Synthesis | W | 4 credits | 3G | T. L. Choi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Modern polymer synthesis (beased on recent development of new orgnic reactions) is discussed to enable students to develop synthesis schemes for certain target structures. Both chain (ionic, coordination, ROMP, radical, catalyst-transfer) and step-growth polymerizations (transition metal catalysis) including how to achieve living polymerization or improve selectivity will be discused. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Students should be able to: Identify important polymerization procedures and types of polymerization. Predict eactivities of monomers based on the chemical structures Devise synthetic pathways to produce a given polymer structure. Evaluate properties of macromolecules based on structure and synthesis method. Develop synthesis schemes for target structures and discuss potential applications of polymers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Polymerization is series of continous organic transformation and connects small molecules. The course will give an overview of the following important polymerization procedures: - Mordern Step-growth polymerization - Living Anionic polymerization - Group transfer polymerization (GTP) - Controlled cationic polymerization - Controlled radical polymerization - Coordination polymerization: Ziegler-Natta and Metallocene catalysts - Olefin metathesis polymerization: ROMP, ADMET and cyclopolymerization - Synthesis of conjugated polymers based on transition metal catalysis - Complex macromolecues inlcuding brush and dendronized polymers Students will learn how to deal with chemical structures and reactivities, and be able to suggest reasonable synthetic pathways to a given polymer structure, like conjugated polymers based on transition metal catalysis or complex macromolecues inlcuding brush and dendronized polymers. Aspects like controlling molar masses and structure perfection play a role throughout. The course provides the students with a high-level overview of modern methods of polymer synthesis both in theoretical and practical aspects. It should enable them to develop reasonable synthesis schemes for certain target structures and also to predict the properties of given macromolecules. For all polymers presented, potential or real applications will be discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | They will be uploaded on Moodle | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Lecture notes will be given | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Strong basic knowledge of Organic Chemistry.Any course on Introductory Polymer Chemistry such as " Advanced Building Blocks for Soft Materials" or "Introduction to Macromolecular Chemistry" or equivalent (bachelor level is also sufficient). Please discuss with the lecturer if one is not certain about the prerequisites. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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