Suchergebnis: Katalogdaten im Frühjahrssemester 2023
Biomedical Engineering Master  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Bioelectronics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wahlfächer der Vertiefung Diese Fächer sind für die Vertiefung in Bioelectronics besonders empfohlen. Bei abweichender Fächerwahl konsultieren Sie bitte den Track Adviser. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nummer | Titel | Typ | ECTS | Umfang | Dozierende | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 151-0172-00L | Microsystems II: Devices and Applications | W | 6 KP | 3V + 3U | C. Hierold, C. I. Roman | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The students are introduced to the fundamentals and physics of microelectronic devices as well as to microsystems in general (MEMS). They will be able to apply this knowledge for system research and development and to assess and apply principles, concepts and methods from a broad range of technical and scientific disciplines for innovative products. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The students are introduced to the fundamentals and physics of microelectronic devices as well as to microsystems in general (MEMS), basic electronic circuits for sensors, RF-MEMS, chemical microsystems, BioMEMS and microfluidics, magnetic sensors and optical devices, and in particular to the concepts of Nanosystems (focus on carbon nanotubes), based on the respective state-of-research in the field. They will be able to apply this knowledge for system research and development and to assess and apply principles, concepts and methods from a broad range of technical and scientific disciplines for innovative products. During the weekly 3 hour module on Mondays dedicated to Übungen the students will learn the basics of Comsol Multiphysics and utilize this software to simulate MEMS devices to understand their operation more deeply and optimize their designs. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Transducer fundamentals and test structures Pressure sensors and accelerometers Resonators and gyroscopes RF MEMS Acoustic transducers and energy harvesters Thermal transducers and energy harvesters Optical and magnetic transducers Chemical sensors and biosensors, microfluidics and bioMEMS Nanosystem concepts Basic electronic circuits for sensors and microsystems | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Handouts (on-line) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0566-00L | Recursive Estimation | W | 4 KP | 2V + 1U | R. D'Andrea | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Estimation of the state of a dynamic system based on a model and observations in a computationally efficient way. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Learn the basic recursive estimation methods and their underlying principles. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Introduction to state estimation; probability review; Bayes' theorem; Bayesian tracking; extracting estimates from probability distributions; Kalman filter; extended Kalman filter; particle filter; observer-based control and the separation principle. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Lecture notes available on course website: http://www.idsc.ethz.ch/education/lectures/recursive-estimation.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Requirements: Introductory probability theory and matrix-vector algebra. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 151-0622-00L | Measuring on the Nanometer Scale | W | 2 KP | 2G | A. Stemmer | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Introduction to theory and practical application of measuring techniques suitable for the nano domain. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Conventional techniques to analyze nano structures using photons and electrons: light microscopy with dark field and differential interference contrast; scanning electron microscopy, transmission electron microscopy. Interferometric and other techniques to measure distances. Optical traps. Foundations of scanning probe microscopy: tunneling, atomic force, optical near-field. Interactions between specimen and probe. Current trends, including spectroscopy of material parameters. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Slides available via Moodle (registered participants only). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0630-00L | Nanorobotics | W | 4 KP | 2V + 1U | S. Pané Vidal | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Nanorobotics is an interdisciplinary field that includes topics from nanotechnology and robotics. The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The aim of this course is to expose students to the fundamental and essential aspects of this emerging field. These topics include basic principles of nanorobotics, building parts for nanorobotic systems, powering and locomotion of nanorobots, manipulation, assembly and sensing using nanorobots, molecular motors, and nanorobotics for nanomedicine. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0636-00L | Soft and Biohybrid Robotics  | W | 4 KP | 3G | R. Katzschmann | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Soft and biohybrid robotics are emerging fields taking inspiration from nature to create robots that are inherently safer to interact with. You learn how to create structures, actuators, sensors, models, controllers, and machine learning architectures exploiting the deformable nature of soft robots. You also learn how to apply soft robotic principles to challenges of your research domain. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Learning Objective 1: Solve a robotics challenge with a soft robotic design Step 1: Formulate suitable functional requirements for the challenge Step 2: Select soft robotic actuator material Step 3: Design and fabrication approach suitable for the challenge Step 4: Basic controller for robotic functionality Learning Objective 2: Formulate modeling, control, and learning frameworks for highly articulated robots in real-life scenarios Step 1: Formulate the dynamic skills needed for the real-life scenario Step 2: Pick + combine suitable multiphysics modeling, control + learning techniques for this scenario Step 3: Evaluate the modeling/control approach for a real-life scenario Step 4: Modify and enhance the modeling/control approach and repeat the evaluation Step 5: Choose a learning approach for complex robotic skills Learning Objective 3: Apply the principles of mechanical impedance and embodied intelligence to soft robotic challenges in various domains Step 1: Identify the moving aspects of the problem Step 2: Choose and design the passive and actively-controlled degrees of freedom Step 3: Pick the actuation material based on suitability to your challenge Step 4: Design in detail multiple combinations of body and brain Step 5: Simulate, build, test, fail, and repeat this often and quickly until the soft robot works for simple settings Step 6: Upgrade and validate the robot for a suitable performance under real-world conditions Learning Objective 4: Rethink robotic approaches by moving towards designs made of living materials Step 1: Identify what problems could be easier to solve with a complex living material Step 2: Scout for available works that have potentially tackled the problem with a living material Step 3: Formulate a hypothesis for your new approach with a living material Step 4: Design a minimum viable prototype (MVP) that suitably highlights your new approach | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Students will learn about the latest research advances in material technologies, fabrication, modeling, and machine learning to design, simulate, build, and control soft and biohybrid robots. Part 1: Functional and intelligent materials for use in soft and biohybrid robotic applications Part 2: Design and design morphologies of soft robotic actuators and sensors Part 3: Fabrication techniques including 3D printing, casting, roll-to-roll, tissue engineering Part 4: Biohybrid robotics including microrobots and macrorobots; tissue engineering Part 5: Mechanical modeling including minimal parameter models, finite-element models, and ML-based models Part 6: Closed-loop controllers of soft robots that exploit the robot's impedance and dynamics for locomotion and manipulation tasks Part 7: Machine Learning approaches to soft robotics, for design synthesis, modeling, and control Regular assignments throughout the semester will teach the participants to implement the skills and knowledge learned during the class. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | All class materials including slides, recordings, assignments, pre-reads, and tutorials can be found on the Moodle page of the class. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | 1) Yasa et al. "An Overview of Soft Robotics." Annu. Rev. Control Robot. Auton. Syst. (2023). 6:1–29. 2) Polygerinos et al. "Soft robotics: Review of fluid‐driven intrinsically soft devices; manufacturing, sensing, control, and applications in human‐robot interaction." Advanced Engineering Materials 19.12 (2017): 1700016. 3) Cianchetti, et al. "Biomedical applications of soft robotics." Nature Reviews Materials 3.6 (2018): 143-153. 4) Ricotti et al. "Biohybrid actuators for robotics: A review of devices actuated by living cells." Science Robotics 2.12 (2017). 5) Sun et al. "Biohybrid robotics with living cell actuation." Chemical Society Reviews 49.12 (2020): 4043-4069. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | - Prerequesites are dynamics, controls, and intro to robotics. - Only for students at master or PhD level. - Due to the limited places, the priority goes first to students from the Robotics, Systems and Control Master and second to the other study programs where the course is offered. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 151-0638-00L | MaP Distinguished Lecture Series on Engineering with Living Materials This course is primarily designed for MSc and doctoral students. Guests are welcome. Former title: MaP Distinguished Lecture Series on Soft Robotics | W | 1 KP | 2S | R. Katzschmann, M. Filippi, X.‑H. Qin, Z. Zhang | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course is an interdisciplinary colloquium on the engineering of biohybrid systems and robotics. Internationally renowned speakers from academia and industry give lectures about their cutting-edge research, which highlights the state-of-the-art and frontiers in the field of engineering with living materials and biohybrids. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Participants become acquainted with the state-of-the-art and frontiers in biohybrid systems and robotics, which is a topic of global and future relevance from the field of materials and process engineering. The self-study of relevant literature and active participation in discussions following presentations by internationally renowned speakers stimulate critical thinking and allow participants to deliberately discuss challenges and opportunities with leading academics and industrial experts and to exchange ideas within an interdisciplinary community. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This course is a colloquium involving a selected mix of internationally renowned speakers from academia and industry who present their cutting-edge research in the field of engineered systems using living materials. In particular, the course will cover fundamentals of bioengineering at a multicellular level (biofabrication), as well as examples of manufacturing and application of living cells to engineered systems for medical applications and beyond. Speakers will show how to combine living cells with non-living, synthetic materials to realize bio-hybrid systems to be applied to many fields of human life, ranging from biomedicine to robotics, biosensing, ecology, and architecture. It will be shown how bio-hybrid technologies and cutting-edge engineering techniques can support cell proliferation and even enhance their cell functions. The course will cover materials and approaches for the biofabrication of living tissue, seen as a biomedical model for pathophysiological discovery research, or as transplantable grafts for tissue regeneration. Speakers will illustrate how living species can contribute to ecological approaches in town planning (such as CO2 sequestration), sensing and processor technologies enabled by connective and signaling abilities of cells, and motile systems actuated by contractile cells (bio-hybrid robots). The main learning objective is to learn about: materials and techniques to build intelligent biological systems for future, sustainable societies; mechanisms of cell and tissue programmability; and applications in bio-robotics, communication, sensing technologies, and medical engineering. The self-study of relevant pre-read literature provided in advance of each lecture serves as a basis for active participation in the critical discussions following each presentation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Selected scientific pre-read literature (around two articles per lecture) relevant for and discussed during the lectures is posted in advance on the course web page. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | This course is taught by a selection of internationally renowned speakers from academia and industry working in the field of bio-hybrid systems and robotics. This lecture series is focusing on the recent trends in engineering with living materials. Participants should have a background in tissue engineering, material science, and/or robotics. To obtain credits, students need to: (i) attend 80% of all lectures; (ii) submit a one-page abstract of 3 different lectures. The performance will be assessed with a "Pass/Fail" format. On-site attendance to the lectures is preferred to foster in-person contacts. However, for lectures given by online speakers, a Zoom link to attend remotely will be provided on Moodle. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 151-0641-00L | Introduction to Robotics and Mechatronics Number of participants limited to 60. Enrollment is only valid through registration on the MSRL website (www.msrl.ethz.ch). Registrations per e-mail is no longer accepted! | W | 4 KP | 2V + 2U | B. Nelson, Q. Boehler, J. Lussi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The aim of this lecture is to expose students to the fundamentals of mechatronic and robotic systems. Over the course of these lectures, topics will include how to interface a computer with the real world, different types of sensors and their use, different types of actuators and their use. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | An ever-increasing number of mechatronic systems are finding their way into our daily lives. Mechatronic systems synergistically combine computer science, electrical engineering, and mechanical engineering. Robotics systems can be viewed as a subset of mechatronics that focuses on sophisticated control of moving devices. The aim of this course is to practically and theoretically expose students to the fundamentals of mechatronic and robotic systems. Over the course of the semester, the lecture topics will include an overview of robotics, an introduction to different types of sensors and their use, the programming of microcontrollers and interfacing these embedded computers with the real world, signal filtering and processing, an introduction to different types of actuators and their use, an overview of computer vision, and forward and inverse kinematics. Throughout the course, students will periodically attend laboratory sessions and implement lessons learned during lectures on real mechatronic systems. By the end of the course, you will be able to independently choose, design and integrate these different building blocks into a working mechatronic system. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The course consists of weekly lectures and lab sessions. The weekly topics are the following: 0. Course Introduction 1. C Programming 2. Sensors 3. Data Acquisition 4. Signal Processing 5. Digital Filtering 6. Actuators 7. Computer Vision and Kinematics 8. Modeling and Control 9. Review and Outlook The lecture schedule can be found on our course page on the MSRL website (www.msrl.ethz.ch) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | The students are expected to be familiar with C programming. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 151-0952-00L | Nanophotonics: from Fundamentals to Applications | W | 4 KP | 2V + 2U | D. J. Norris, R. Quidant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Nanophotonics exploits the unique optical properties of nanostructured materials to boost our control over light, beyond what conventional optics can do. In particular, nanophotonics has proven to offer a unique toolbox to engineer light on the nanometer scale, benefiting a wide spectrum of scientific disciplines, ranging from physics, chemistry, biology, and engineering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The purpose of this course is threefold: (i) to introduce students to the principal concepts of nanophotonics, (ii) to describe some of the main nanophotonics implementations to control light on the nanometer scale, and finally (iii) to present specific applications where nanophotonics has made breakthrough contributions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | I- INTRODUCTORY CONCEPTS 1. The diffraction limit and the challenges of conventional optics 2. The optical near field 3. Reminders on light-matter interaction 4. Reminders on optical resonators II- PLASMONICS 1. Surface plasmon polaritons 2. Localized surface plasmons 3. Hot carriers 4. Thermoplasmonics III- DIELECTRIC NANOPHOTONICS 1. Mie resonances in subwavelength particles 2. Electric versus magnetic resonances 3. Mode engineering and directional scattering 4. Dielectric nanophotonics versus plasmonics IV- ARTIFICIAL PHOTONIC MATERIALS 1. Photonic crystals 2. Metamaterials 3. Topological photonics 4. Flat optics, metasurfaces & metalenses V- APPLICATIONS 1. Renewable energy 2. Biomedicine 3. Information and Communication Technology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Class notes and handouts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | - Introduction to Nanophotonics - Benisty, Greffet & Lalanne - Absorption and scattering of light by small particles - Bohren & Huffman - Thermoplasmonics - Baffou - Plasmonics - Maier | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Physics, Introduction to Photonics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 151-0980-00L | Biofluiddynamics | W | 4 KP | 2V + 1U | D. Obrist, P. Jenny | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Introduction to the fluid dynamics of the human body and the modeling of physiological flow processes (biomedical fluid dynamics). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | A basic understanding of fluid dynamical processes in the human body. Knowledge of the basic concepts of fluid dynamics and the ability to apply these concepts appropriately. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This lecture is an introduction to the fluid dynamics of the human body (biomedical fluid dynamics). For selected topics of human physiology, we introduce fundamental concepts of fluid dynamics (e.g., creeping flow, incompressible flow, flow in porous media, flow with particles, fluid-structure interaction) and use them to model physiological flow processes. The list of studied topics includes the cardiovascular system and related diseases, blood rheology, microcirculation, respiratory fluid dynamics and fluid dynamics of the inner ear. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Lecture notes are provided electronically. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | A list of books on selected topics of biofluiddynamics can be found on the course web page. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-1046-00L | Computer Simulations of Sensory Systems | W | 3 KP | 3G | T. Haslwanter | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course deals with computer simulations of the human auditory, visual, and balance system. The lecture will cover the physiological and mechanical mechanisms of these sensory systems. And in the exercises, the simulations will be implemented with Python. The simulations will be such that their output could be used as input for actual neuro-sensory prostheses. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Our sensory systems provide us with information about what is happening in the world surrounding us. Thereby they transform incoming mechanical, electromagnetic, and chemical signals into “action potentials”, the language of the central nervous system. The main goal of this lecture is to describe how our sensors achieve these transformations, how they can be reproduced with computational tools. For example, our auditory system performs approximately a “Fourier transformation” of the incoming sound waves; our early visual system is optimized for finding edges in images that are projected onto our retina; and our balance system can be well described with a “control system” that transforms linear and rotational movements into nerve impulses. In the exercises that go with this lecture, we will use Python to reproduce the transformations achieved by our sensory systems. The goal is to write programs whose output could be used as input for actual neurosensory prostheses: such prostheses have become commonplace for the auditory system, and are under development for the visual and the balance system. For the corresponding exercises, at least some basic programing experience is required! | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The following topics will be covered: • Introduction into the signal processing in nerve cells. • Introduction into Python. • Simplified simulation of nerve cells (Hodgkins-Huxley model). • Description of the auditory system, including the application of Fourier transforms on recorded sounds. • Description of the visual system, including the retina and the information processing in the visual cortex. The corresponding exercises will provide an introduction to digital image processing. • Description of the mechanics of our balance system, and the “Control System”-language that can be used for an efficient description of the corresponding signal processing (essentially Laplace transforms and control systems). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | For each module additional material will be provided on the e-learning platform "moodle". The main content of the lecture is also available as a wikibook, under http://en.wikibooks.org/wiki/Sensory_Systems | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Open source information is available as wikibook http://en.wikibooks.org/wiki/Sensory_Systems For good overviews of the neuroscience, I recommend: • Principles of Neural Science (5th Ed, 2012), by Eric Kandel, James Schwartz, Thomas Jessell, Steven Siegelbaum, A.J. Hudspeth ISBN 0071390111 / 9780071390118 THE standard textbook on neuroscience. NOTE: The 6th edition will be released on February 5, 2021! • L. R. Squire, D. Berg, F. E. Bloom, Lac S. du, A. Ghosh, and N. C. Spitzer. Fundamental Neuroscience, Academic Press - Elsevier, 2012 [ISBN: 9780123858702]. This book covers the biological components, from the functioning of an individual ion channels through the various senses, all the way to consciousness. And while it does not cover the computational aspects, it nevertheless provides an excellent overview of the underlying neural processes of sensory systems. • G. Mather. Foundations of Sensation and Perception, 2nd Ed Psychology Press, 2009 [ISBN: 978-1-84169-698-0 (hardcover), oder 978-1-84169-699-7 (paperback)] A coherent, up-to-date introduction to the basic facts and theories concerning human sensory perception. • The best place to get started with Python programming are the https://scipy-lectures.org/ On signal processing with Python, my upcoming book • Hands-on Signal Analysis with Python (Due: January 13, 2021 ISBN 978-3-030-57902-9, https://www.springer.com/gp/book/9783030579029) will contain an explanation to all the required programming tools and packages. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | •Since I have to travel from Linz, Austria, to Zurich to give this lecture, I plan to hold this lecture online every 2nd week. In addition to the lectures, this course includes external lab visits to institutes actively involved in research on the relevant sensory systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0125-00L | Optics and Photonics | W | 6 KP | 2V + 2U | J. Leuthold | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This lecture covers both - the fundamentals of "Optics" such as e.g. "ray optics", "coherence", the "Planck law", the "reciprocity theorem" or the "Einstein relations" but also the fundamentals of "Photonics" on the generation (the laser), processing, transmission and detection of photons. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | A sound base for work in the field of optics and photonics will be conveyed. Key principles of optics will the thaught. The lecture passes on the essentials for work with free-space optics or waveguide optics. In addition important optical devices will be discussed. Among them are e.g. optical filters, copulers (MMI-couplers,...), Holograms,... . | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Chapter 1: Ray Optics Chapter 2: Electromagnetic Optics Chapter 3: Polarization Chapter 4: Coherence and Interference Chapter 5: Fourier Optics and Diffraction Chapter 6: Guided Wave Optics Chapter 7: Optical Fibers Chapter 8: The Laser | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Lecture notes will be handed out. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Fundamentals of Electromagnetic Fields (Maxwell Equations) & Bachelor Lectures on Physics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0395-00L | Neural Systems | W | 6 KP | 2V + 1U + 1A | R. Hahnloser, M. F. Yanik, B. Grewe | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course introduces principles of information processing in neural systems. It covers basic neuroscience for engineering students, experiment techniques used in animal research and methods for inferring neural mechanisms. Students learn about neural information processing and basic principles of natural intelligence and their impact on artificially intelligent systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | This course introduces - Basic neurophysiology and mathematical descriptions of neurons - Methods for dissecting animal behavior - Neural recordings in intact nervous systems and information decoding principles - Methods for manipulating the state and activity in selective neuron types - Neuromodulatory systems and their computational roles - Reward circuits and reinforcement learning - Imaging methods for reconstructing the synaptic networks among neurons - Birdsong and language - Neurobiological principles for machine learning. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | From active membranes to propagation of action potentials. From synaptic physiology to synaptic learning rules. From receptive fields to neural population decoding. From fluorescence imaging to connectomics. Methods for reading and manipulation neural ensembles. From classical conditioning to reinforcement learning. From the visual system to deep convolutional networks. Brain architectures for learning and memory. From birdsong to computational linguistics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Before taking this course, students are encouraged to complete "Bioelectronics and Biosensors" (227-0393-10L). As part of the exercises for this class, students are expected to complete a programming or literature review project to be defined at the beginning of the semester. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0390-00L | Elements of Microscopy | W | 4 KP | 3G | M. Stampanoni, G. Csúcs, A. Sologubenko | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The lecture reviews the basics of microscopy by discussing wave propagation, diffraction phenomena and aberrations. It gives the basics of light microscopy, introducing fluorescence, wide-field, confocal and multiphoton imaging. It further covers 3D electron microscopy and 3D X-ray tomographic micro and nanoimaging. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Solid introduction to the basics of microscopy, either with visible light, electrons or X-rays. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | It would be impossible to imagine any scientific activities without the help of microscopy. Nowadays, scientists can count on very powerful instruments that allow investigating sample down to the atomic level. The lecture includes a general introduction to the principles of microscopy, from wave physics to image formation. It provides the physical and engineering basics to understand visible light, electron and X-ray microscopy. During selected exercises in the lab, several sophisticated instrument will be explained and their capabilities demonstrated. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Available Online. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0622-00L | Applications of Thermal Modeling: From Hot Atoms to Heated Tissues | W | 4 KP | 3G | E. Neufeld, M. Luisier | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | How about leveraging heat to cure cancer or to solve today’s energy crisis? Computational simulation of heat-related phenomena from the atomic-scale to living organisms is key to achieve these goals and will be at the core of this multidisciplinary course. The necessary physics, modeling, and computing background will be covered, from theory to practical implementations in concrete applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | During this course students will: - learn the physics governing the formation and propagation of heat in solids and living human tissues; - discover how heat can be used in personalised cancer therapies or in thermoelectric applications to produce reusable energy; - develop computational models describing electromagnetically-induced heating; - get familiar with computational simulation techniques across a wide range of spatial scales, incl. methods for simulating in vivo heating, considering thermoregulation and perfusion, or more fundamental approaches that consider heat at the level of atomic vibrations; - implement and apply simulation techniques within a state-of-the-art open-source simulation platform for computational life sciences, and a framework for computer-aided design of nanoscale electronic devices; - learn about practical aspects related to performance-critical coding and numerics for computational simulations; - work on two small projects applying the theoretical concepts presented during the lectures to two specific real-world applications where heat modeling is required; - learn about current challenges of high social relevance associated with heat modeling. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The following topics will be covered: - introduction to electromagnetic heating, from its social relevance and history to its application in biology and electronics; - personalised therapies relying on local heating; - thermoelectricity (production of electricity from heat gradients); - microscopic/macroscopic thermal transport including governing equations, numerical methods to solve them, and applications; - numerical algorithms and their implementation, shared and distributed parallelization approaches and pitfalls, use of graphics processing units (GPUs) for hardware acceleration, and solutions for high performance computing; - usage of the Sim4Life simulation platform (therapy planning) and of the OMEN technology computer aided design tool (device simulation) as practical examples; - odel verification and validation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Lecture slides are distributed every week and can be found at https://iis-students.ee.ethz.ch/lectures/thermal-modeling/ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | This course is ideal for students who have an interest in computational sciences, a passion for interdisciplinarity, and generally enjoy problem-solving. The course requires a basic knowledge of Python scripting and C/C++ coding skills, undergraduate entry-level familiarity with electric and magnetic fields/forces, differential equations, calculus, and basic knowledge of biology and physics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 227-0669-00L | Chemistry of Devices and Technologies | W | 4 KP | 1V + 2U | M. Yarema | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The course covers basics of chemistry and material science, relevant for modern devices and technologies. The course consists of interactive classroom activities (lectures, workshops, laboratory sessions) and individual component. For the latter, students accomplish individual projects to study, evaluate, and present a chosen technology from a viewpoint of chemistry and materials science. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The course brings relevant chemistry knowledge, tailored to the needs of electrical engineering students. Students will gain understanding of the basic concepts of chemistry and materials science, acquire technology-related practical and analytic skills through the small group activities, laboratory experiments, workshops, and conference sessions as well as guidance through individual projects that require interdisciplinary and critical thinking. Students will learn which materials, reactions, and device fabrication processes are important for nowadays technologies and products. They will gain important knowledge of state-of-the-art technologies from materials and fabrication viewpoints. Finally, students will choose selected technologies or devices and study them in details in order to establish and understand the link between the structure, properties, and performance of functional materials. By doing this, students will also improve important soft skills, such as academic text writing, presenting, and active learning. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Students will spend 3h per week in the interactive classroom activities (lectures, workshops, laboratory and conference sessions) and additional 4-6h per week working on individual projects. The goal of the individual student's project is to understand the chemistry related to the manufacture and operation of a specific device or technology and how the structure and properties of materials relate to the performance of devices/technologies (students will be able to choose which technology they want to study). To ensure project-based continued learning throughout the semester, students will receive a matching information during the classroom activities. Individual projects will be evaluated by three interim project reports and by a final presentation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Lecture notes will be made available on the website. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0690-11L | Large-Scale Convex Optimization | W | 4 KP | 2V + 1U | M. Mühlebach | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Convex optimization has revolutionized modern decision making and underpins many scientific and engineering disciplines. To enable its use in modern large-scale applications, we require new analytical methods that address limitations of existing solutions. This course is intended to provide a comprehensive overview of convex analysis and numerical methods for large-scale optimization. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Students should be able to apply the fundamental results in convex analysis and numerical methods to analyze and solve large-scale convex optimization problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Convex analysis and methods for large-scale optimization. Topics will include: convex sets and functions ; duality theory ; optimality and infeasibility conditions ; structured optimization problems ; gradient-based methods ; operator splitting methods ; distributed and decentralized optimization ; applications in various research areas. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Available on the course Moodle platform. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Sufficient mathematical maturity, in particular in linear algebra and analysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0690-12L | Advanced Topics in Control | W | 4 KP | 2V + 2U | F. Dörfler, M. Hudoba de Badyn | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Advanced Topics in Control (ATIC) covers advanced research topics in control theory. It is offered each Spring semester with the topic rotating from year to year. Repetition for credit is possible, with consent of the instructor. During the spring of 2020, the course will cover a range of topics in distributed systems control. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | By the end of this course you will have developed a sound and versatile toolkit to tackle a range of problems in network systems and distributed systems control. In particular, we will develop the methodological foundations of algebraic graph theory, consensus algorithms, and multi-agent systems. Building on top of these foundations we cover a range of problems in epidemic spreading over networks, swarm robotics, sensor networks, opinion dynamics, distributed optimization, and electrical network theory. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Distributed control systems include large-scale physical systems, engineered multi-agent systems, as well as their interconnection in cyber-physical systems. Representative examples are electric power grids, swarm robotics, sensor networks, and epidemic spreading over networks. The challenges associated with these systems arise due to their coupled, distributed, and large-scale nature, and due to limited sensing, communication, computing, and control capabilities. This course covers algebraic graph theory, consensus algorithms, stability of network systems, distributed optimization, and applications in various domains. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | A complete set of lecture notes and slides will be provided. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | The course will be largely based on the following set of lecture notes co-authored by one of the instructors: http://motion.me.ucsb.edu/book-lns/ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Sufficient mathematical maturity, in particular in linear algebra and dynamical systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 227-0966-00L | Quantitative Big Imaging: From Images to Statistics | W | 4 KP | 2V + 1U | P. A. Kaestner, M. Stampanoni | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The lecture focuses on the challenging task of extracting robust, quantitative metrics from imaging data and is intended to bridge the gap between pure signal processing and the experimental science of imaging. The course will focus on techniques, scalability, and science-driven analysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | 1. Introduction of applied image processing for research science covering basic image processing, quantitative methods, and statistics. 2. Understanding of imaging as a means to accomplish a scientific goal. 3. Ability to apply quantitative methods to complex 3D data to determine the validity of a hypothesis | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Imaging is a well established field and is rapidly growing as technological improvements push the limits of resolution in space, time, material and functional sensitivity. These improvements have meant bigger, more diverse datasets being acquired at an ever increasing rate. With methods varying from focused ion beams to X-rays to magnetic resonance, the sources for these images are exceptionally heterogeneous; however, the tools and techniques for processing these images and transforming them into quantitative, biologically or materially meaningful information are similar. The course consists of equal parts theory and practical analysis of first synthetic and then real imaging datasets. Basic aspects of image processing are covered such as filtering, thresholding, and morphology. From these concepts a series of tools will be developed for analyzing arbitrary images in a very generic manner. Specifically a series of methods will be covered, e.g. characterizing shape, thickness, tortuosity, alignment, and spatial distribution of material features like pores. From these metrics the statistics aspect of the course will be developed where reproducibility, robustness, and sensitivity will be investigated in order to accurately determine the precision and accuracy of these quantitative measurements. A major emphasis of the course will be scalability and the tools of the 'Big Data' trend will be discussed and how cluster, cloud, and new high-performance large dataset techniques can be applied to analyze imaging datasets. In addition, given the importance of multi-scale systems, a data-management and analysis approach based on modern databases will be presented for storing complex hierarchical information in a flexible manner. Finally as a concluding project the students will apply the learned methods on real experimental data from the latest 3D experiments taken from either their own work / research or partnered with an experimental imaging group. The course provides the necessary background to perform the quantitative evaluation of complicated 3D imaging data in a minimally subjective or arbitrary manner to answer questions coming from the fields of physics, biology, medicine, material science, and paleontology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Available online. https://imaginglectures.github.io/Quantitative-Big-Imaging-2023/weeklyplan.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Will be indicated during the lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Ideally, students will have some familiarity with basic manipulation and programming in languages like Python, Matlab, or R. Interested students who are worried about their skill level in this regard are encouraged to contact Anders Kaestner directly (anders.kaestner@psi.ch). More advanced students who are familiar with Python, C++, (or in some cases Java) will have to opportunity to develop more of their own tools. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 227-0973-00L | Translational Neuromodeling | W | 8 KP | 3V + 2U + 1A | K. Stephan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course provides an introduction to Translational Neuromodeling (the development of computational assays of neuronal and cognitive processes) and their application to concrete clinical questions (Computational Psychiatry/Psychosomatics). It focuses on a generative modeling strategy and teaches (hierarchical) Bayesian models of neuroimaging data and behaviour, incl. exercises and project work. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | To obtain an understanding of the goals, concepts and methods of Translational Neuromodeling and Computational Psychiatry/Psychosomatics, particularly with regard to Bayesian models of neuroimaging (fMRI, EEG) and behavioural data. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This course provides a systematic introduction to Translational Neuromodeling (the development of computational assays of neuronal and cognitive processes) and their application to concrete clinical questions (Computational Psychiatry/Psychosomatics). The first part of the course will introduce disease concepts from psychiatry and psychosomatics, their history, and clinical priority problems. The second part of the course concerns computational modeling of neuronal and cognitive processes for clinical applications. A particular focus is on Bayesian methods and generative models, for example, dynamic causal models for inferring neuronal processes from neuroimaging data, and hierarchical Bayesian models for inference on cognitive processes from behavioural data. The course discusses the mathematical and statistical principles behind these models, illustrates their application to various psychiatric diseases, and outlines a general research strategy based on generative models. Lecture topics include: 1. Introduction to Translational Neuromodeling and Computational Psychiatry/Psychosomatics 2. Psychiatric nosology 3. Pathophysiology of psychiatric disease mechanisms 4. Principles of Bayesian inference and generative modeling 5. Variational Bayes (VB) 6. Bayesian model selection 7. Markov Chain Monte Carlo techniques (MCMC) 8. Bayesian frameworks for understanding psychiatric and psychosomatic diseases 9. Generative models of fMRI data 10. Generative models of electrophysiological data 11. Generative models of behavioural data 12. Computational concepts of schizophrenia and depression 13. Generative embedding: Model-based predictions about individual patients Practical exercises include mathematical derivations and the implementation of specific models and inference methods. In additional project work, students are required to either develop a novel generative model (and demonstrate its properties in simulations) or devise novel applications of an existing model to empirical data in order to address a clinical question. Group work (up to 3 students) is required. Please note that some of the exercises involve the use of open source software in Matlab. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | See TNU website: https://www.tnu.ethz.ch/en/teaching | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Good knowledge of principles of statistics, good programming skills (the majority of the open source software tools used is in MATLAB; for project work, Julia can also be used) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 227-0976-00L | Computational Psychiatry & Computational Psychosomatics Findet dieses Semester nicht statt. Information for UZH students: Enrolment to this course unit only possible at ETH Zurich. No enrolment to module BMT20002. Please mind the ETH enrolment deadlines for UZH students: Link | W | 2 KP | 4S | K. Stephan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This seminar deals with the development of clinically relevant computational tools and/or their application to psychiatry and psychosomatics. Complementary to the annual Computational Psychiatry Course, it serves to build bridges between computational scientists and clinicians and is designed to foster in-depth exchange, with ample time for discussion | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Understanding strengths and weaknesses of current trends in the development of clinically relevant computational tools and their application to problems in psychiatry and psychosomatics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This seminar deals with the development of computational tools (e.g. generative models, machine learning) and/or their application to psychiatry and psychosomatics. The seminar includes (i) presentations by computational scientists and clinicians, (ii) group discussion with focus on methodology and clinical utility, (iii) self-study based on literature provided by presenters. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Literature for additional self-study of the topics presented in this seminar will be provided by the presenters and will be available online at https://www.tnu.ethz.ch/en/teaching | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Participants are expected to be familiar with general principles of statistics (including Bayesian statistics) and have successfully completed the course “Computational Psychiatry” (Course number 227-0971-00L). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 252-0220-00L | Introduction to Machine Learning Preference is given to students in programmes in which the course is being offered. All other students will be waitlisted. Please do not contact Prof. Krause for any questions in this regard. If necessary, please contact studiensekretariat@inf.ethz.ch | W | 8 KP | 4V + 2U + 1A | A. Krause, F. Yang | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The course introduces the foundations of learning and making predictions based on data. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The course will introduce the foundations of learning and making predictions from data. We will study basic concepts such as trading goodness of fit and model complexitiy. We will discuss important machine learning algorithms used in practice, and provide hands-on experience in a course project. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | - Linear regression (overfitting, cross-validation/bootstrap, model selection, regularization, [stochastic] gradient descent) - Linear classification: Logistic regression (feature selection, sparsity, multi-class) - Kernels and the kernel trick (Properties of kernels; applications to linear and logistic regression); k-nearest neighbor - Neural networks (backpropagation, regularization, convolutional neural networks) - Unsupervised learning (k-means, PCA, neural network autoencoders) - The statistical perspective (regularization as prior; loss as likelihood; learning as MAP inference) - Statistical decision theory (decision making based on statistical models and utility functions) - Discriminative vs. generative modeling (benefits and challenges in modeling joint vy. conditional distributions) - Bayes' classifiers (Naive Bayes, Gaussian Bayes; MLE) - Bayesian approaches to unsupervised learning (Gaussian mixtures, EM) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Designed to provide a basis for following courses: - Advanced Machine Learning - Deep Learning - Probabilistic Artificial Intelligence - Seminar "Advanced Topics in Machine Learning" | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 252-0312-00L | Mobile Health and Activity Monitoring | W | 6 KP | 2V + 3A | C. Holz | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Health and activity monitoring has become a key purpose of mobile & wearable devices, e.g., phones, watches, and rings. We will cover the phenomena they capture, i.e., user behavior, actions, and human physiology, as well as the sensors, signals, and methods for processing and analysis. For the exercise, students will receive a wristband to stream and analyze activity and health signals. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The course will combine high-level concepts with low-level technical methods needed to sense, detect, and understand them. High-level: – sensing modalities for interactive systems – "activities" and "events" (exercises and other mechanical activities such as movements and resulting vibrations) – health monitoring (basic cardiovascular physiology) – affective computing (emotions, mood, personality) Lower-level: – sampling and filtering, time and frequency domains – cross-modal sensor systems, signal synchronization and correlation – event detection, classification, prediction using basic signal processing as well as learning-based methods – sensor types: optical, mechanical/acoustic, electromagnetic | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Health and activity monitoring has become a key purpose of mobile and wearable devices, including phones, (smart) watches, (smart) rings, (smart) belts, and other trackers (e.g., shoe clips, pendants). In this course, we will cover the fundamental aspects that these devices observe, i.e., user behavior, actions, and physiological dynamics of the human body, as well as the sensors, signals, and methods to capture, process, and analyze them. We will then cover methods for pattern extraction and classification on such data. The course will therefore touch on aspects of human activities, cardiovascular and pulmonary physiology, affective computing (recognizing, interpreting, and processing emotions), corresponding lower-level sensing systems (e.g., inertial sensing, optical sensing, photoplethysmography, eletrodermal activity, electrocardiograms) and higher-level computer vision-based sensing (facial expressions, motions, gestures), as well as processing methods for these types of data. The course will be accompanied by a group exercise project, in which students will apply the concepts and methods taught in class. Students will receive a wearable wristband device that streams IMU data to a mobile phone (code will be provided for receiving, storing, visualizing on the phone). Throughout the course and exercises, we will collect data of various human activities from the band, annotate them, analyze, classify, and interpret them. For this, existing and novel processing methods will be developed (plenty of related work exists), based on the collected data as well as existing datasets. We will also combine the band with signals obtained from the mobile phone to holistically capture and analyze health and activity data. Full details: https://teaching.siplab.org/mobile_health_activity_monitoring/2023/ Note: All lectures will be streamed live and recorded for later replay. Hybrid participation will be possible. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Copies of slides will be made available Lectures will be streamed live as well as recorded and made available online. More information on the course site: https://teaching.siplab.org/mobile_health_activity_monitoring/2023/ Note: All lectures will be streamed live and recorded for later replay. Hybrid participation will be possible. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Will be provided in the lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 252-1424-00L | Models of Computation | W | 6 KP | 2V + 2U + 1A | M. Cook | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course surveys many different models of computation: Turing Machines, Cellular Automata, Finite State Machines, Graph Automata, Circuits, Tilings, Lambda Calculus, Fractran, Chemical Reaction Networks, Hopfield Networks, String Rewriting Systems, Tag Systems, Diophantine Equations, Register Machines, Primitive Recursive Functions, and more. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The goal of this course is to become acquainted with a wide variety of models of computation, to understand how models help us to understand the modeled systems, and to be able to develop and analyze models appropriate for new systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This course surveys many different models of computation: Turing Machines, Cellular Automata, Finite State Machines, Graph Automata, Circuits, Tilings, Lambda Calculus, Fractran, Chemical Reaction Networks, Hopfield Networks, String Rewriting Systems, Tag Systems, Diophantine Equations, Register Machines, Primitive Recursive Functions, and more. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 261-5120-00L | Machine Learning for Health Care | W | 5 KP | 2V + 2A | V. Boeva, J. Vogt, M. Kuznetsova | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The course will review the most relevant methods and applications of Machine Learning in Biomedicine, discuss the main challenges they present and their current technical problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | During the last years, we have observed a rapid growth in the field of Machine Learning (ML), mainly due to improvements in ML algorithms, the increase of data availability and a reduction in computing costs. This growth is having a profound impact in biomedical applications, where the great variety of tasks and data types enables us to get benefit of ML algorithms in many different ways. In this course we will review the most relevant methods and applications of ML in biomedicine, discuss the main challenges they present and their current technical solutions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The course will consist of four topic clusters that will cover the most relevant applications of ML in Biomedicine: 1) Structured time series: Temporal time series of structured data often appear in biomedical datasets, presenting challenges as containing variables with different periodicities, being conditioned by static data, etc. 2) Medical notes: Vast amount of medical observations are stored in the form of free text, we will analyze stategies for extracting knowledge from them. 3) Medical images: Images are a fundamental piece of information in many medical disciplines. We will study how to train ML algorithms with them. 4) Genomics data: ML in genomics is still an emerging subfield, but given that genomics data are arguably the most extensive and complex datasets that can be found in biomedicine, it is expected that many relevant ML applications will arise in the near future. We will review and discuss current applications and challenges. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Data Structures & Algorithms, Introduction to Machine Learning, Statistics/Probability, Programming in Python, Unix Command Line Relation to Course 261-5100-00 Computational Biomedicine: This course is a continuation of the previous course with new topics related to medical data and machine learning. The format of Computational Biomedicine II will also be different. It is helpful but not essential to attend Computational Biomedicine before attending Computational Biomedicine II. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 376-1217-00L | Rehabilitation Engineering I: Motor Functions | W | 4 KP | 2V + 1U | R. Riener, C. E. Awai | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | “Rehabilitation” is the (re)integration of an individual with a disability into society. Rehabilitation engineering is “the application of science and technology to ameliorate the handicaps of individuals with disability”. Such handicaps can be classified into motor, sensor, and cognitive disabilities. In general, one can distinguish orthotic and prosthetic methods to overcome these disabilities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The goal of this course is to present classical and new technical principles as well as specific examples applied to compensate or enhance motor deficits. In the 1 h exercise the students will learn how to solve representative problems with computational methods applied to exoprosthetics, wheelchair dynamics, rehabilitation robotics and neuroprosthetics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Modern methods rely more and more on the application of multi-modal and interactive techniques. Multi-modal means that visual, acoustical, tactile, and kinaesthetic sensor channels are exploited to display information to the patient. Interaction means that the exchange of information and energy occurs bi-directionally between the rehabilitation device and the human being. Thus, the device cooperates with the patient rather than imposing an inflexible strategy (e.g., movement) upon the patient. These principles are recurrent in modern technological tools to support rehabilitation, including prosthesis, orthoses, powered exoskeletons, powered wheelchairs, therapy robots and virtual reality systems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Books: Burdet, Etienne, David W. Franklin, and Theodore E. Milner. Human robotics: neuromechanics and motor control. MIT press, 2013. Krakauer, John W., and S. Thomas Carmichael. Broken movement: the neurobiology of motor recovery after stroke. MIT Press, 2017. Teodorescu, Horia-Nicolai L., and Lakhmi C. Jain, eds. Intelligent systems and technologies in rehabilitation engineering. CRC press, 2000. Winters, Jack M., and Patrick E. Crago, eds. Biomechanics and neural control of posture and movement. Springer Science & Business Media, 2012. Selected Journal Articles: Abbas, James J., and Robert Riener. "Using mathematical models and advanced control systems techniques to enhance neuroprosthesis function." Neuromodulation: Technology at the Neural Interface 4.4 (2001): 187-195. Basalp, Ekin, Peter Wolf, and Laura Marchal-Crespo. "Haptic training: which types facilitate (re) learning of which motor task and for whom Answers by a review." IEEE Transactions on Haptics (2021). Calabrò, Rocco Salvatore, et al. "Robotic gait rehabilitation and substitution devices in neurological disorders: where are we now?." Neurological Sciences 37.4 (2016): 503-514. Cooper, R. (1993) Stability of a wheelchair controlled by a human. IEEE Transactions on Rehabilitation Engineering 1, pp. 193-206. Gassert, Roger, and Volker Dietz. "Rehabilitation robots for the treatment of sensorimotor deficits: a neurophysiological perspective." Journal of neuroengineering and rehabilitation 15.1 (2018): 1-15. Laver, Kate E., et al. "Virtual reality for stroke rehabilitation." Cochrane database of systematic reviews 11 (2017). Marquez-Chin, Cesar, and Milos R. Popovic. "Functional electrical stimulation therapy for restoration of motor function after spinal cord injury and stroke: a review." Biomedical engineering online 19 (2020): 1-25. Miller, Larry E., Angela K. Zimmermann, and William G. Herbert. "Clinical effectiveness and safety of powered exoskeleton-assisted walking in patients with spinal cord injury: systematic review with meta-analysis." Medical devices (Auckland, NZ) 9 (2016): 455. Raspopovic, Stanisa. "Advancing limb neural prostheses." Science 370.6514 (2020): 290-291. Riener, R. (2013) Rehabilitation Robotics. Foundations and Trends in Robotics, Vol. 3, nos. 1-2, pp. 1-137. Riener, R., Lünenburger, L., Maier, I. C., Colombo, G., & Dietz, V. (2010). Locomotor training in subjects with sensori-motor deficits: An overview of the robotic gait orthosis Lokomat. Journal of Healthcare Engineering, 1(2), 197-216. Riener, R., Nef, T., Colombo, G. (2005) Robot-aided neurorehabilitation for the upper extremities. Medical & Biological Engineering & Computing 43(1), pp. 2-10. Sigrist, Roland, et al. "Augmented visual, auditory, haptic, and multimodal feedback in motor learning: a review." Psychonomic bulletin & review 20.1 (2013): 21-53. Xiloyannis, Michele, et al. "Soft Robotic Suits: State of the Art, Core Technologies, and Open Challenges." IEEE Transactions on Robotics (2021). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Target Group: Students of higher semesters and PhD students of - D-MAVT, D-ITET, D-INFK - Biomedical Engineering - Medical Faculty, University of Zurich Students of other departments, faculties, courses are also welcome | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 376-1308-00L | Development Strategies for Medical Implants | W | 3 KP | 2V + 1U | J. Mayer-Spetzler, N. Mathavan | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Introduction to development strategies for implantable devices considering the interdependencies of biocompatibility, clinical, regulatory, and economical requirements; discussion of state of the art and actual trends in orthopedics, sports medicine, cardiovascular surgery, and regenerative medicine (tissue engineering). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Primary considerations in implant development. Concept of structural and surface biocompatibility and its relevance for implant design and surgical technique. Understanding conflicting factors, e.g., clinical need, economics, and regulatory requirements. Tissue engineering concepts, their strengths, and weaknesses as current and future clinical solutions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Understanding of clinical and economic needs as guidelines for the development of medical implants; implant and implantation-related tissue reactions, biocompatible materials, and material processing technologies; implant testing and regulatory procedures; discussion of state-of-the-art and actual trends in implant development in sports medicine, spinal and cardio-vascular surgery; introduction to tissue engineering. Commented movies from surgeries will further illustrate selected topics. Seminar: Group seminars on selected controversial topics in implant development. Participation is mandatory. Planned excursions (limited availability, not mandatory, to be confirmed): Participation (as a visitor) in a life surgery (travel at own expense) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Script (electronically available): - presented slides - selected scientific papers for further reading | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Reference to key papers will be provided during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Only Master's students; achieved Bachelor's degree is a pre-condition Admission to the lecture is based on a letter of motivation to the lecturer J. Mayer. The number of participants in the course is limited to 30 students in total. Students will be exposed to surgical movies which may cause emotional reactions. The viewing of the surgical movies is voluntary and is the student's responsibility. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 376-1397-00L | Orthopaedic Biomechanics | W | 3 KP | 2G | R. Müller, J. Schwiedrzik | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course is aimed at studying the mechanical and structural engineering of the musculoskeletal system alongside the analysis and design of orthopaedic solutions to musculoskeletal failure. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | To apply engineering and design principles to orthopaedic biomechanics, to quantitatively assess the musculoskeletal system and model it, and to review rigid-body dynamics in an interesting context. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Engineering principles are very important in the development and application of quantitative approaches in biology and medicine. This course includes a general introduction to structure and function of the musculoskeletal system: anatomy and physiology of musculoskeletal tissues and joints; biomechanical methods to assess and quantify tissues and large joint systems. These methods will also be applied to musculoskeletal failure, joint replacement and reconstruction; implants; biomaterials and tissue engineering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Stored on Moodle. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | Orthopaedic Biomechanics: Mechanics and Design in Musculoskeletal Systems Authors: Donald L. Bartel, Dwight T. Davy, Tony M. Keaveny Publisher: Prentice Hall; Copyright: 2007 ISBN-10: 0130089095; ISBN-13: 9780130089090 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Lectures will be given in English. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 376-1614-00L | Principles in Tissue Engineering | W | 3 KP | 2V | K. Maniura, M. Rottmar, M. Zenobi-Wong | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Fundamentals in blood coagulation; thrombosis, blood rheology, immune system, inflammation, foreign body reaction on the molecular level and the entire body are discussed. Applications of biomaterials for tissue engineering in different tissues are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Understanding of molecular aspects for the application of biodegradable and biocompatible Materials. Fundamentals of tissue reactions (eg. immune responses) against implants and possible clinical consequences will be discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This class continues with applications of biomaterials and devices introduced in Biocompatible Materials I. Fundamentals in blood coagulation; thrombosis, blood rheology; immune system, inflammation, foreign body reaction on the level of the entire body and on the molecular level are introduced. Applications of biomaterials for tissue engineering in the vascular system, skeletal muscle, heart muscle, tendons and ligaments, bone, teeth, nerve and brain, and drug delivery systems are introduced. Fundamentals in medical implantology, in situ drug release, cell transplantation and stem cell biology are discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Handouts provided during the classes and references therin. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | The molecular Biology of the Cell, Alberts et al., 5th Edition, 2009. Principles in Tissue Engineering, Langer et al., 2nd Edition, 2002 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 376-1712-00L | Finite Element Analysis in Biomedical Engineering | W | 3 KP | 2V | S. J. Ferguson, B. Helgason | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Finite element analysis is a powerful simulation method for the (approximate) solution of boundary value problems. While its traditional roots are in the realm of structural engineering, the methods have found wide use in the biomedical engineering domain for the simulation of the mechanical response of the human body and medical devices. This course provides an introduction to finite element analysis, with a specific focus on problems and applications from biomedical engineering. This domain offers many unique challenges, including multi-scale problems, multi-physics simulation, complex and non-linear material behaviour, rate-dependent response, dynamic processes and fluid-solid interactions. Theories taught are reinforced through practical applications in self-programmed and commercial simulation software, using e.g. MATLAB, ANSYS, FEBIO. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | (Theory) The Finite Element and Finite Difference methods Gallerkin, weighted residuals, discretization (Theory) Mechanical analysis of structures Trusses, beams, solids and shells, DOFs, hand calculations of simple FE problems, underlying PDEs (Application) Mechanical analysis of structures Truss systems, beam systems, 2D solids, meshing, organ level analysis of bones (Theory and Application) Mechanical analysis of structures Micro- and multi-scale analysis, voxel models, solver limitations, large scale solvers (Theory) Non-linear mechanical analysis of structures Large strain, Newton-Rhapson, plasticity (Application) Non-linear mechanical analysis of structures Plasticity (bone), hyperelasticity, viscoelasticity (Theory and Application) Contact analysis Friction, bonding, rough contact, implants, bone-cement composites, pushout tests (Theory) Flow in Porous Media Potential problems, Terzhagi's consolidation (Application) Flow in Porous Media Confined and unconfined compression of cartilage (Theory) Heat Transfer and Mass Transport Diffusion, conduction and convection, equivalency of equations (Application) Heat Transfer and Mass Transport Sequentially-coupled poroelastic and transport models for solute transport (Theory) Computational Biofluid Dynamics Newtonian vs. Non-Newtonian fluid, potential flow (Application) Computational Biofluid Dynamics Flow between micro-rough parallel plates | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | Handouts consisting of (i) lecturers' script, (ii) selected excerpts from relevant textbooks, (iii) selected excerpts from theory manuals of commercial simulation software, (iv) relevant scientific publications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Familiarity with basic numerical methods. Programming experience with MATLAB. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 376-1984-00L | Lasers in Medicine Findet dieses Semester nicht statt. | W | 3 KP | 3G | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Fragen wie "Was ist ein Laser, wie funktioniert er und was macht ihn so interessant für die Medizin?", aber auch "Wie breitet sich Licht im Gewebe aus und welche Wechselwirkungen treten dabei auf?" sollen beantwortet werden. Speziell wird auf therapeutische, diagnostische und bildgebende Anwendungen anhand von ausgewählten Beispielen eingegangen. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Sie wissen wie ein Laser funktioniert und wie er aufgebaut ist und verstehen die physikalischen Prinzipien eines Lasers. Sie kennen die Eigenschaften von Laserlicht und wie diese für medizinische Zwecke eingesetzt werden können. Sie können unterschiedlichen Laser-Gewebe-Wechselwirkungen erklären und wissen welche Parameter diese beeinflussen. Sie können erklären, was Auflösung, Kontrast und Vergrösserung bedeutet. Sie sind in der Lage eine Laserschutzbrille für Ihr Lasersystem zu bestellen. Sie sind in der Lage für eine gezielte klinische Anwendung die richtigen Laserparameter zu bestimmen. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Die Anwendung des Lasers in der Medizin gewinnt zunehmend dort an Bedeutung, wo seine speziellen Eigenschaften gezielt zur berührungslosen, selektiven und spezifischen Wirkung auf Weich- und Hartgewebe für minimal invasive Therapieformen oder zur Eröffnung neuer therapeutischer und diagnostischer Methoden eingesetzt werden können. Grundlegende Arbeiten zum Verständnis der Lichtausbreitung im Gewebe (Absorptions-, Reflexions- und Transmissionsvermögen) und die unterschiedlichen Formen der Wechselwirkung (photochemische, thermische, ablative und optomechanische Wirkung) werden eingehend behandelt. Speziell wird auf den Einfluss der Wellenlänge und der Bestrahlungszeit auf den Wechselwirkungsmechanismus eingegangen. Die unterschiedlichen medizinisch genutzten Lasertypen und Strahlführungssysteme werden hinsichtlich ihres Einsatzes im Bereich der Medizin anhand ausgesuchter Anwendungsbeispiele diskutiert. Neben den therapeutischen Wirkungen wird auf den Einsatz des Lasers in der medizinischen Diagnostik (z.B. Tumor-Fluoreszenzdiagnostik, Bildgebung) eingegangen. Die beim Einsatz des Lasers in der Medizin erforderlichen Schutzmassnahmen werden diskutiert. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | wird im Internet bereitgestellt (ILIAS) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | - M. Born, E. Wolf, "Principles of Optics", Pergamon Press - B.E.A. Saleh, M.C. Teich, "Fundamentals of Photonics", John Wiley and Sons, Inc. - A.E. Siegman, "Lasers", University Science Books - O. Svelto, "Principles of Lasers", Plenum Press - J. Eichler, T. Seiler, "Lasertechnik in der Medizin", Springer Verlag - M.H. Niemz, "Laser-Tissue Interaction", Springer Verlag - A.J. Welch, M.J.C. van Gemert, "Optical-thermal response of laser-irradiated tissue", Plenum Press | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 402-0343-00L | Physics Against Cancer: The Physics of Imaging and Treating Cancer Fachstudierende UZH müssen das Modul PHY361 direkt an der UZH buchen. | W | 6 KP | 2V + 1U | A. J. Lomax, U. Schneider | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | Radiotherapy is a rapidly developing and technology driven medical discipline that is heavily dependent on physics and engineering. In this lecture series, we will review and describe some of the current developments in radiotherapy, particularly from the physics and technological view point, and will indicate in which direction future research in radiotherapy will lie. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | Radiotherapy is a rapidly developing and technology driven medical discipline that is heavily dependent on physics and engineering. In the last few years, a multitude of new techniques, equipment and technology have been introduced, all with the primary aim of more accurately targeting and treating cancerous tissues, leading to a precise, predictable and effective therapy technique. In this lecture series, we will review and describe some of the current developments in radiotherapy, particularly from the physics and technological view point, and will indicate in which direction future research in radiotherapy will lie. Our ultimate aim is to provide the student with a taste for the critical role that physics plays in this rapidly evolving discipline and to show that there is much interesting physics still to be done. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | The lecture series will begin with a short introduction to radiotherapy and an overview of the lecture series (lecture 1). Lecture 2 will cover the medical imaging as applied to radiotherapy, without which it would be impossible to identify or accurately calculate the deposition of radiation in the patient. This will be followed by a detailed description of the treatment planning process, whereby the distribution of deposited energy within the tumour and patient can be accurately calculated, and the optimal treatment defined (lecture 3). Lecture 4 will follow on with this theme, but concentrating on the more theoretical and mathematical techniques that can be used to evaluate different treatments, using mathematically based biological models for predicting the outcome of treatments. The role of physics modeling, in order to accurately calculate the dose deposited from radiation in the patient, will be examined in lecture 5, together with a review of mathematical tools that can be used to optimize patient treatments. Lecture 6 will investigate a rather different issue, that is the standardization of data sets for radiotherapy and the importance of medical data bases in modern therapy. In lecture 7 we will look in some detail at one of the most advanced radiotherapy delivery techniques, namely Intensity Modulated Radiotherapy (IMRT). In lecture 8, the two topics of imaging and therapy will be somewhat combined, when we will describe the role of imaging in the daily set-up and assessment of patients. Lecture 9 follows up on this theme, in which a major problem of radiotherapy, namely organ motion and changes in patient and tumour geometry during therapy, will be addressed, together with methods for dealing with such problems. Finally, in lectures 10-11, we will describe in some of the multitude of different delivery techniques that are now available, including particle based therapy, rotational (tomo) therapy approaches and robot assisted radiotherapy. In the final lecture, we will provide an overview of the likely avenues of research in the next 5-10 years in radiotherapy. The course will be rounded-off with an opportunity to visit a modern radiotherapy unit, in order to see some of the techniques and delivery methods described in the course in action. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Although this course is seen as being complimentary to the Medical Physics I and II course of Dr Manser, no previous knowledge of radiotherapy is necessarily expected or required for interested students who have not attended the other two courses. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 402-0673-00L | Physics in Medical Research: From Humans to Cells | W | 6 KP | 2V + 1U | B. K. R. Müller | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The aim of this lecture series is to introduce the role of physics in state-of-the-art medical research and clinical practice. Topics to be covered range from applications of physics in medical implant technology and tissue engineering, through imaging technology, to its role in interventional and non-interventional therapies. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The lecture series is focused on applying knowledge from physics in diagnosis, planning, and therapy close to clinical practice and fundamental medical research. Beside a general overview, the lectures give a deep insight into a very few selected techniques, which will help the students to apply the knowledge to a broad range of related techniques. In particular, the lectures will elucidate the physics behind the X-ray imaging currently used in clinical environment and contemporary high-resolution developments. It is the goal to visualize and quantify microstructures of human tissues and implants as well as their interface. Physicists in medicine are working on modeling and simulation. Based on the vascular structure in cancerous and healthy tissues, the characteristic approaches in computational physics to develop strategies against cancer are presented. In order to deliberately destroy cancerous tissue, heat can be supplied or extracted in different manner: cryotherapy (heat conductivity in anisotropic, viscoelastic environment), radiofrequency treatment (single and multi-probe), laser application, and proton therapy. Mechanical stimuli can drastically influence soft and hard tissue behavior. The students should realize that a physiological window exists, where a positive tissue response is expected and how the related parameter including strain, frequency, and resting periods can be selected and optimized for selected tissues such as bone. For the treatment of severe incontinence, we are developing artificial smart muscles. The students should have a critical look at promising solutions and the selection procedure as well as realize the time-consuming and complex way to clinical practice. The course will be completed by relating the numerous examples and a common round of questions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | This lecture series will cover the following topics: Physics in Medical Research: From humans to cells - introduction and overview Hard X-ray-based computed tomography in clinics and related research Conventional microtomography for tissue and implant characterization Synchrotron radiation-based tomography of medically relevant objects Comparing microtomography in absorption- and phase-contrast modes Tomographic imaging of cells and subcellular structures Physical approaches in medical imaging Unconventional approaches in hard X-ray imaging: Iterative reconstruction for laminography Quantitative evaluation of medically relevant, three-dimensional data Nondestructive imaging of unique objects: Physicists support museum science From open surgery to non-invasive interventions – role of medical imaging Artificial muscles for treating severe incontinence Applying physics in medicine: Benefitting patients | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | http://www.bmc.unibas.ch/education/ETH_Zurich.phtml login and password to be provided during the lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Students from other departments are very welcome to join and gain insight into a variety of sophisticated techniques for the benefit of patients. No special knowledge is required. Nevertheless, gaps in basic physical knowledge will require additional efforts. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kompetenzen |
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| 465-0952-00L | Biomedical Photonics | W | 3 KP | 2V | M. Frenz | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kurzbeschreibung | The lecture introduces the principles of light generation, light propagation in tissue and detection of light and its therapeutic and diagnostic application in medicine. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lernziel | The students are expected to aquire a basic understanding of the fundamental physical principles within biomedical photonics. In particular, they will develop a broad skill set for research in fundamentals of light-tissue interaction, technologies such as microscopy, lasers and fiber optics and issues related to light applications in therapeutics and diagnostics in medicine. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inhalt | Optics always was strongly connected to the observation and interpretation of physiological phenomenon. The basic knowledge of optics for example was initially gained by studying the function of the human eye. Nowadays, biomedical optics is an independent research field that is no longer restricted to the observation of physiological processes but studies diagnostic and therapeutic problems in medicine. A basic prerequisite for applying optical techniques in medicine is the understanding of the physical properties of light, the light propagation in and its interaction with tissue. The lecture gives inside into the generation, propagation and detection of light, its propagation in tissue and into selected optical applications in medicine. Various optical imaging techniques (optical coherence tomography or optoacoustics) as well as therapeutic laser applications (refractive surgery, photodynamic therapy or nanosurgery) will be discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Skript | will be provided via Internet (Ilias) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literatur | - M. Born, E. Wolf, "Principles of Optics", Pergamon Press - B.E.A. Saleh, M.C. Teich, "Fundamentals of Photonics", John Wiley and Sons, Inc. - O. Svelto, "Principles of Lasers", Plenum Press - J. Eichler, T. Seiler, "Lasertechnik in der Medizin", Springer Verlag - M.H. Niemz, "Laser-Tissue Interaction", Springer Verlag - A.J. Welch, M.J.C. van Gemert, "Optical-thermal response of laser-irradiated tissue", Plenum Press | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Voraussetzungen / Besonderes | Language of instruction: English This is the same course unit (465-0952-00L) with former course title "Medical Optics". | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||