Search result: Catalogue data in Autumn Semester 2023
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 Master Studies (Programme Regulations 2023) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Major in Biological Chemistry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Compulsory Concept Courses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0731-00L | Nucleic Acids and Carbohydrates Note for BSc Biology students: Only one of the two concept courses 529-0731-00 Nucleic Acids and Carbohydrates (autumn semester) or 529-0732-00 Proteins and Lipids (spring semester) can be counted for the Bachelor's degree. | O | 6 credits | 3G | K. Lang, P. A. Kast, S. J. Sturla, H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | No script; illustrations from the original literature relevant to the individual lectures will be provided weekly (typically as handouts downloadable from the Moodle server). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Mainly based on original literature, a detailed list will be distributed during the lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Elective Compulsory Master Courses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0004-01L | Classical Simulation of (Bio)Molecular Systems | W | 6 credits | 4G | P. H. Hünenberger, J. Dolenc, S. Riniker | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Molecular models, classical force fields, configuration sampling, molecular dynamics simulation, boundary conditions, electrostatic interactions, analysis of trajectories, free-energy calculations, structure refinement, applications in chemistry and biology. Exercises: hands-on computer exercises for learning progressively how to perform an analyze classical simulations (using the package GROMOS). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Introduction to classical (atomistic) computer simulation of (bio)molecular systems, development of skills to carry out and interpret these simulations. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Molecular models, classical force fields, configuration sampling, molecular dynamics simulation, boundary conditions, electrostatic interactions, analysis of trajectories, free-energy calculations, structure refinement, applications in chemistry and biology. Exercises: hands-on computer exercises for learning progressively how to perform an analyze classical simulations (using the package GROMOS). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | The powerpoint slides of the lectures will be made available weekly on the website in pdf format (on the day preceding each lecture). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | See: www.csms.ethz.ch/education/CSBMS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Since the exercises on the computer do convey and test essentially different skills than those being conveyed during the lectures and tested at the oral exam, the results of the exercises are taken into account when evaluating the results of the exam (learning component, possible bonus of up to 0.25 points on the exam mark). For more information about the lecture: www.csms.ethz.ch/education/CSBMS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0233-01L | Organic Synthesis: Methods and Strategies | W | 6 credits | 3G | E. M. Carreira | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The complex relation between structural analysis, methods leading to desired transformations, and insight into reaction mechanisms is exemplified. Relations between retrosynthetic analysis of target structures, synthetic methods and their combination in a synthetic strategy. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Extension and deepening of the knowledge in organic synthesis and the principles of structure and reactivity. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Concepts of the planning of organic synthesis (strategy and tactics), retrosynthetic analysis. Structure-reactivity relation in the context of the synthesis of complex molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis, Wiley-VCH 1996. K. C. Nicolaou, S. A. Snyder, Classics in Total Synthesis II, Wiley-VCH 2003. K. C. Nicolaou, J. Chen, Classics in Total Synthesis III, Wiley-VCH 2011. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | OC I-IV | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0243-01L | Transition Metal Catalysis: From Mechanisms to Applications | W | 6 credits | 3G | B. Morandi | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding and critical evaluation of current research in transition metal catalysis. Design of mechanistic experiments to elucidate reaction mechanisms. Synthetic relevance of transition metal catalysis. Students will also learn about writing an original research proposal during a workshop. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint. Synthetic applications of these reactions. Introduction and application of tools for the elucidation of mechanisms. Selected examples of topics include: C-H activation, C-O activation, C-C activation, redox active ligands, main group redox catalysis, bimetallic catalysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture slides will be provided online. A Handout summarizing important concepts in organometallic and physical organic chemistry will also be provided. Useful references and handouts will also be provided during the workshop. Slides will be uploaded 1-2 days before each lecture on http://morandi.ethz.ch/education.html | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Primary literature and review articles will be cited during the course. The following textbooks can provide useful support for the course: - Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books. - Crabtree R., The Organometallic Chemistry of the Transition Metals, John Wiley & Sons, Inc. - Hartwig J., Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books. - J. P. Collman, L. S. Hegedus, J. R. Norton, R. G. Finke, Principles and Applications of Organotransition Metal Chemistry. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Required level: Courses in organic and physical chemistry (kinetics in particular) of the first and second year as well as ACI and III | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0041-00L | Modern Mass Spectrometry, Hyphenated Methods, and Chemometrics | W | 6 credits | 3G | R. Zenobi, B. Hattendorf, P. Sinués Martinez-Lozano | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Modern mass spectrometry, hyphenated analytical methods, speciation, chemometrics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Comprehensive knowledge about the analytical methods introduced in this course and their practical applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Hyphenation of separation with identification methods such as GC-MS, LC-MS, GC-IR, LC-IR, LC-NMR etc.; importance of speciation. Modern mass spectrometry: time-of-flight, orbitrap and ion cyclotron resonance mass spectrometry, ICP-MS. Soft ionization methods, desorption methods, spray methods. Mass spectrometry imaging. Use of statistical and computer-assisted methods for processing analytical data (chemometrics). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture notes will be made available online. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Information about relevant literature will be available in the lecture & in the lecture notes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Exercises are an integral part of the lecture. Prerequisites: 529-0051-00 "Analytische Chemie I (3. Semester)" 529-0058-00 "Analytische Chemie II (4. Semester)" (or equivalent) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0240-00L | Chemical Biology - Peptides | W | 6 credits | 3G | H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | An advanced course on the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Knowledge of the synthesis, properties and function of peptides in chemistry and biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Advanced peptide synthesis, conformational properties, combinatorial chemistry, therapeutic peptides, peptide based materials, peptides in nanotechnology, peptides in asymmetric catalysis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Citations from the original literature relevant to the individual lectures will be assigned weekly. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Norbert Sewald, Hans Dieter Jakubke "Peptides: Chemistry and Biology", 1st edition, Wiley VCH, 2002. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 636-0108-00L | Biological Engineering and Biotechnology | W | 4 credits | 3V | M. Fussenegger | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Biological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | 1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Handout during the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1407-00L | RNA Biology Lecture Series I: Transcription & Processing & Translation Does not take place this semester. | W | 4 credits | 2V | F. Allain, N. Ban, S. Jonas, U. Kutay, further lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course covers aspects of RNA biology related to gene expression at the posttranscriptional level. These include RNA transcription, processing, alternative splicing, editing, export and translation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The students should obtain an understanding of these processes, which are at work during gene expression. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Transcription & 3'end formation ; splicing, alternative splicing, RNA editing; the ribosome & translation, translation regulation, RNP biogenesis & nuclear export, mRNA surveillance & mRNA turnover; signal transduction & RNA. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Basic knowledge of cell and molecular biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-1409-00L | RNA Biology Lecture Series II: Non-Coding RNAs: Biology and Therapeutics | W | 4 credits | 2V | J. Hall, M. Stoffel, further lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This course covers aspects of RNA biology related to the functions of non-coding RNAs as well as their use as drugs to treat diseases. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The students should get familiar with the wide array of roles, which non-coding RNAs play in cellular functions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Micro RNAs; computational approaches to miRNAs; micro RNA function in metabolism; viruses and viral RNAs; nucleic acid-based drugs; ncRNA-mediated genome regulation; epigenetic programming of genome remodelling in ciliates; telomerase and telomeres; tRNA biology. http://www.nccr-rna-and-disease.ch/tiki-index.php?page=LectureSeries | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Basic knowledge of cell and molecular biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0241-10L | Selectivity in Organic Synthesis | W | 6 credits | 3G | J. W. Bode | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Fundamentals of selective organic reactions, including current and historical examples of enantioselectivity, regioselectivity, chemoselectivity. Further aspects include recent developments in catalysis, strategies and tools for selective organic synthesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding and explaining the origin of selectivity in organic synthesis and the application of selective organic reactions to the construction of complex organic and biological molecules. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Fundamental concepts and recent advances for the selective synthesis of complex organic molecules, including natural products, pharmaceuticals, and biological molecules. Key concepts include the development of enantioselective and regioselective catalysts, the identification of new reaction mechanisms and pathways, and technological advances for facilitating the synthesis of organic molecules. Analysis of key primarily literature including identification of trends, key precendents, and emerging topics will be emphasized. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | will be provided in class and online | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Suggesting Textbooks Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books, 2006. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 227-0939-00L | Cell Biophysics | W | 6 credits | 4G | T. Zambelli | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Applying two fundamental principles of thermodynamics (entropy maximization and Gibbs energy minimization), an analytical model is derived for a variety of biological phenomena at the molecular as well as cellular level, and critically compared with the corresponding experimental data in the literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Engineering uses the laws of physics to predict the behavior of a system. Biological systems are so diverse and complex prompting the question whether we can apply unifying concepts of theoretical physics coping with the multiplicity of life’s mechanisms. Objective of this course is to show that biological phenomena despite their variety can be analytically described using only two principles from statistical mechanics: maximization of the entropy and minimization of the Gibbs free energy. Starting point of the course is the probability theory, which enables to derive step-by-step the two pillars of thermodynamics from the perspective of statistical mechanics: the maximization of entropy according to the Boltzmann’s law as well as the minimization of the Gibbs free energy. Then, an assortment of biological phenomena at the molecular and cellular level (e.g. cytoskeletal polymerization, action potential, photosynthesis, gene regulation, morphogen patterning) will be examined at the light of these two principles with the aim to derive a quantitative expression describing their behavior. Each analytical model is finally validated by comparing it with the corresponding experimental results from the literature. By the end of the course, students will also learn to critically evaluate the concepts of making an assumption and making an approximation. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | • Basics of theory of probability • Boltzmann's law • Entropy maximization and Gibbs free energy minimization • Ligand-receptor: two-state systems and the MWC model • Random walks, diffusion, crowding • Electrostatics for salty solutions • Elasticity: fibers and membranes • Molecular motors • Action potential: Hodgkin-Huxley model • Photosynthesis and vision • Gene regulation • Development: Turing patterns Theory and corresponding exercises are merged together during the classes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | No lecture notes because the two proposed textbooks are more than exhaustive! An extra hour (Mon 17.00 o'clock - 18.00) will be proposed via ZOOM to solve together the exercises of the previous week. !!!!! I am using OneNote. All lectures and exercises will be broadcast via ZOOM (the link of the recordings will be available in Moodle on Fri, 22 Dec after the last lesson) !!!!! | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | • (Statistical Mechanics) K. Dill, S. Bromberg, "Molecular Driving Forces", 2nd Edition, Garland Science, 2010. • (Biophysics) R. Phillips, J. Kondev, J. Theriot, H. Garcia, "Physical Biology of the Cell", 2nd Edition, Garland Science, 2012. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Participants need a good command of • differentiation and integration of a function with one or more variables (basics of Analysis), • Newton's and Coulomb's laws (basics of Mechanics and Electrostatics). Notions of vectors in 2D and 3D are beneficial. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-0357-00L | Cellular Matters: Properties, Functions and Applications of Biomolecular Condensates The number of participants is limited to 30 and will only take place with a minimum of 6 participants. The first lecture will serve to form groups of students and assign papers. | W | 4 credits | 2S | T. Michaels, F. Allain, P. Arosio, Y. Barral, D. Hilvert, M. Jagannathan, R. Mezzenga, G. Neurohr, R. Riek, A. E. Smith, K. Weis, H. Wennemers, further lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This Master level course delves into the emerging field of biomolecular condensates - membrane-less organelles in cells. Using interdisciplinary concepts from biology, chemistry, biophysics, and soft matter, we will explore the biological properties of these condensates, their functions in health and disease, and their potentiol as new biomimetic materials for various applications. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | In the last decade, a novel type of cell compartments called biomolecular condensates have been discovered. This discovery is radically changing our understanding of the cell, its organization, and dynamics. The emerging picture is that the cytoplasm and nucleoplasm are highly complex fluids that can (meta)stably segregate into membrane-less compartments, similary to emulsions. This interdisciplinary course encompasses milestone works and cutting-edge research questions in the young field of biomolecular condensates, including their properties, functions, and applications. The course begins with a lecture series that introduces the topic of condensates to an interdisciplinary audience and provides a theoretical foundation for understanding current research questions in the field. the lecturesprovide a base for student presentations of recent publications in the field, and for research seminars given by course lecturers, who are all active researchers with diverse expertise. Through this exciting interdisciplinary understanding of biomolecular condensates, bridging biology, chemistry, biophysics, and soft matter. Students will not only learn how to critically read and evaluate scientific literature but will also gain valuable experience in giving scientific presentations to an interdisciplinary audience. Each presentation will require an introduction, critical analysis of the results, and a discussion of their significance, allowing student to substantiate their statements with a critical mindset that considers the pros and cons of chosen approaches and methods, as well as any limitations or possible follow-up experiments. This process will enable student to ask relevant querions and actively participate in class discussions, further enhancing their scientific skills. In preparing the presentations, the students will have the unique opportunity to interact closely with each other and with the lecturers, who are all internationally well-established experts, and receive guidance in selectin a topic for the final presentaton and supporting literature. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The topic of biomolecular condensates goes beyond the boundaries of traditional disciplines and requires a multi-disciplinary approach that leverages and cross-fertilizes biology, physical chemistry, biophysics, and soft matter. This course will explore the properties, functions and potentioal applicatons of biomolecular condensates, including their role in neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as their use as smart biomimetic materials. This course is divided into two parts. The fist part will introduce the basic concepts essentialto the study of biomolecular condensates and phase separation. Topics include: fundamental units and scales in soft matter, phase transitions in biology, biopolymers and molecular self-assembly, introduction to active matter. This will establish a foundation for the second part, which will explore milestone works and current research in the field of biomolecular condensates. Each lecture of this second part will consist of: 1) a short literature seminar, where student groups will present and discuss a milestone paper assigned in advance and 2) a research seminar, where one of the course lecturers will present their own state-of-the art research in the field, building upon the milestone literature. At the beginning of the course, student groups will be formed and assigned the milestone papers. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture slides and some scripts will be provided. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | No compulsory textbooks. Literature will be provided during the course | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0733-02L | Chemical Biology and Synthetic Biochemistry | W | 6 credits | 3G | K. Lang, M. Fottner | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Overview of modern chemical biology and synthetic biochemistry techniques, focussed on protein modification and labeling and on methods to endow proteins with novel functionalities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | After taking this course, students should be capable of the following: A) Recall different possibilities for modifying proteins in vitro and in vivo and their applications in a biological context, B) Understand the chemical and biochemical consequences of modifications and assess the different reaction possibilities in the context of in vivo - in vitro, C) Critically analyze and assess current chemical biology articles D) Question the approaches learned and apply them to new biological problems. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | principles of protein labeling and protein modification (fluorescent proteins, enzyme-mediated labeling, bioorthogonal chemistries) advanced genetic code expansion methods (amber suppression, orthogonal ribosomes, unnatural base pairs, genome engineering and genome editing) directed evolution and protein engineering chemical biology of ubiquitin and targeted protein degradation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | A script will not be handed out. Handouts to the lecture will be provided through moodle. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Citations from the original literature relevant to the individual lectures will be assigned during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Knowledge provided in the bachelor lectures 'Nucleic Acids and Carbohydrates' and 'Proteins and Lipids' is assumed for this lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| Elective Concept Courses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-0307-00L | Molecular and Structural Biology I: Protein Structure and Function D-BIOL students are obliged to take part I and part II (next semester) as a two-semester course | W | 3 credits | 2V | R. Glockshuber, K. Locher, E. Weber-Ban | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Biophysics of protein folding, membrane proteins and biophysics of membranes, enzymatic catalysis, catalytic RNA and RNAi, current topics in protein biophysics and structural biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding of structure-function relationships in proteins and in protein folding, detailed understanding of biophysics and physical methods as well as modern methods for protein purification and microanalytics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts on the individual topics can be found under http://www.mol.biol.ethz.ch/teaching. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Basics: - Creighton, T.E., Proteins, Freeman, (1993) - Fersht, A., Enzyme, Structure and Mechanism in Protein Science (1999), Freeman. - Berg, Tymoczko, Stryer: Biochemistry (5th edition), Freeman (2001). Current topics: References will be given during the lectures. . | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-0319-00L | Cellular Biochemistry (Part I) | W | 3 credits | 2V | U. Kutay, F. Allain, T. Kleele, I. Zemp | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Concepts and molecular mechanisms underlying the biochemistry of the cell, providing advanced insights into structure, function and regulation of individual cell components. Particular emphasis will be put on the spatial and temporal integration of different molecules and signaling pathways into global cellular processes such as intracellular transport, cell division & growth, and cell migration. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The full-year course (551-0319-00 & 551-0320-00) focuses on the molecular mechanisms and concepts underlying the biochemistry of cellular physiology, investigating how these processes are integrated to carry out highly coordinated cellular functions. The molecular characterisation of complex cellular functions requires a combination of approaches such as biochemistry, but also cell biology and genetics. This course is therefore the occasion to discuss these techniques and their integration in modern cellular biochemistry. The students will be able to describe the structural and functional details of individual cell components, and the spatial and temporal regulation of their interactions. In particular, they will learn to explain the integration of different molecules and signaling pathways into complex and highly dynamic cellular processes such as intracellular transport, cytoskeletal rearrangements, cell motility, cell division and cell growth. In addition, they will be able to illustrate the relevance of particular signaling pathways for cellular pathologies such as cancer. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Structural and functional details of individual cell components, regulation of their interactions, and various aspects of the regulation and compartmentalisation of biochemical processes. Topics include: biophysical and electrical properties of membranes; viral membranes; structural and functional insights into intracellular transport and targeting; vesicular trafficking and phagocytosis; post-transcriptional regulation of gene expression. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts and additional material will be provided during the semester. Please contact Dr. Alicia Smith for assistance with the learning materials. (alicia.smith@bc.biol.ethz.ch) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Recommended supplementary literature (review articles and selected primary literature) will be provided during the course. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | To attend this course the students must have a solid basic knowledge in chemistry, biochemistry and general biology. The course will be taught in English. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-1299-00L | Bioinformatics  | W | 6 credits | 4G | S. Sunagawa, P. Beltrao, V. Boeva, A. Kahles, C. von Mering, N. Zamboni | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Students will study bioinformatic concepts in the areas of metagenomics, genomics, transcriptomics, proteomics, biological networks and biostatistics. Through integrated lectures, practical hands-on exercises and project work, students will also be trained in analytical and programming skills to meet the emerging increase in data-driven knowledge generation in biology in the 21st century. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Students will have an advanced understanding of the underlying concepts behind modern bioinformatic analyses at genome, metagenome and proteome-wide scales. They will be familiar with the most common data types, where to access them, and how to analytically work with them to address contemporary questions in the field of biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Course participants have already acquired basic programming skills in UNIX, Python and R. Students bring their own computer with keyboard, internet access (browser) and software to connect to the ETH network via VPN. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 551-0309-00L | Concepts in Modern Genetics Information for UZH students: Enrolment to this course unit only possible at ETH. No enrolment to module BIO348 at UZH. Please mind the ETH enrolment deadlines for UZH students: Link | W | 6 credits | 4V | Y. Barral, D. Bopp, A. Hajnal, O. Voinnet | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Concepts of modern genetics and genomics, including principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This course focuses on the concepts of classical and modern genetics and genomics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The topics include principles of classical genetics; yeast genetics; gene mapping; forward and reverse genetics; structure and function of eukaryotic chromosomes; molecular mechanisms and regulation of transcription, replication, DNA-repair and recombination; analysis of developmental processes; epigenetics and RNA interference. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts and additional material will be provided during the semester. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
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| 551-0313-00L | Microbiology (Part I) | W | 3 credits | 2V | W.‑D. Hardt, L. Eberl, B. Nguyen, J. Piel, M. Pilhofer, A. Vagstad | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Advanced lecture class providing a broad overview on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | This concept class will be based on common concepts and introduce to the enormous diversity among bacteria and archaea. It will cover the current research on bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Advanced class covering the state of the research in bacterial cell structure, genetics, metabolism, symbiosis and pathogenesis. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Updated handouts will be provided during the class. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Current literature references will be provided during the lectures. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | English The lecture "Grundlagen der Biologie II: Mikrobiologie" is the basis for this advanced lecture. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Recommended Mastercourses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 551-0575-00L | Writing Scientific Reports for MSc Biology | W | 2 credits | 1G | R. Taylor | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | This short course is designed to accompany MSc students in writing their first reports in English, providing input on scientific writing in English as well as feedback on drafts sections of the report. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Students will learn to: - Plan, draft, structure, and edit scientific reports - Produce reader-friendly sentences - Establish a clear and logical flow between sentences and paragraphs - Select formal vocabulary and use it in a generally accurate and correct manner - Choose and use generally suitable grammatical structures, punctuation, and identify areas in which further development is needed | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course covers the process of writing reports in biology, helping students to focus on the language and communicative aspects of these reports. Topics covered include structuring sentences, paragraphs, and longer sections (introductions, methods, etc.); presenting and integrating non-textual elements such as graphs and tables; reviewing common grammar problems for advanced writers in English; and editing drafts and proofs. Sessions will consist of a mix of specialist input, group and pair work, and editing sessions. Students who attend this cous will turn in three sections of a report (approx. 500 words each) for feedback, revising these texts for a final portfolio that is graded. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | Participants should be at a stage in their research where they can already start drafting parts of the report. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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