Search result: Catalogue data in Autumn Semester 2023
Biochemistry – Chemical Biology Bachelor  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Second and Third Year Core Courses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Examination Block II | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 551-0307-00L | Molecular and Structural Biology I: Protein Structure and Function D-BIOL students are obliged to take part I and part II (next semester) as a two-semester course | O | 3 credits | 2V | R. Glockshuber, K. Locher, E. Weber-Ban | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Biophysics of protein folding, membrane proteins and biophysics of membranes, enzymatic catalysis, catalytic RNA and RNAi, current topics in protein biophysics and structural biology. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Understanding of structure-function relationships in proteins and in protein folding, detailed understanding of biophysics and physical methods as well as modern methods for protein purification and microanalytics. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Scripts on the individual topics can be found under http://www.mol.biol.ethz.ch/teaching. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Basics: - Creighton, T.E., Proteins, Freeman, (1993) - Fersht, A., Enzyme, Structure and Mechanism in Protein Science (1999), Freeman. - Berg, Tymoczko, Stryer: Biochemistry (5th edition), Freeman (2001). Current topics: References will be given during the lectures. . | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 529-0731-00L | Nucleic Acids and Carbohydrates Note for BSc Biology students: Only one of the two concept courses 529-0731-00 Nucleic Acids and Carbohydrates (autumn semester) or 529-0732-00 Proteins and Lipids (spring semester) can be counted for the Bachelor's degree. | O | 6 credits | 3G | K. Lang, P. A. Kast, S. J. Sturla, H. Wennemers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | Structure, function and chemistry of nucleic acids and carbohydrates. DNA/RNA structure and synthesis; recombinant DNA technology and PCR; DNA arrays and genomics; antisense approach and RNAi; polymerases and transcription factors; catalytic RNA; DNA damage and repair; carbohydrate structure and synthesis; carbohydrate arrays; cell surface engineering; carbohydrate vaccines | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | No script; illustrations from the original literature relevant to the individual lectures will be provided weekly (typically as handouts downloadable from the Moodle server). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Mainly based on original literature, a detailed list will be distributed during the lecture | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| 529-0018-00L | Organic Chemistry for Biochemistry and Chemical Biology | O | 6 credits | 3G | J. W. Bode | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract | The synthesis and reactivity of organic molecules plays a crucial role in chemical biology, particularly for the interrogation of biological pathways and phenomena. This course will cover advanced topics in the design and synthesis of organic molecules for applications in biochemistry and chemical biology, with particular emphasis on the mechanistic understanding of these reactions and processes. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | After the completion of this lecture, the students will have an understanding of organic chemistry commonly employed in the field of chemical biology, be able to apply these concepts to the design and synthesis of tools for probing biological pathways, and explain the underlying reaction mechanisms of selective reactions. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Content | The course will discuss past and recent advances in the synthesis of biomolecules, organic chemistry for applications in chemical biology, and the mechanism of relevant reactions. Topics will include chemical ligations, bioorthoganal reactions, photoaffinity probes, photopharmacology, activity based probes, targeted protein degraders, chemical probes for metabolites, fluorescent dyes and imaging, caged biomolecules, conditional activation, site-specific protein modification, and metabolic engineering. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | Lecture notes and other material relevant for the course will be available online under https://bode.ethz.ch/education.html. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Literature | Relevant research articles and review papers will be available in the course and course material. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | This is an advanced organic chemistry course. Prior knowledge of organic synthesis, reactions, and mechanisms is required. Familiarity with biochemistry and biology is recommended. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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