Search result: Catalogue data in Autumn Semester 2024
Biology Bachelor  | |||||||||||||||||||||||||||||||||||||||||||||
 Third Year Courses | |||||||||||||||||||||||||||||||||||||||||||||
| Block Courses Registration for Block courses is mandatory. Please register under https://www.mybioportal.uzh.ch. Registration period: from 22.07.2024 - 09.08.2024 Please note the ETH admission criteria for the admission of ETH students to ETH block courses on the block course registration website under "allocation". | |||||||||||||||||||||||||||||||||||||||||||||
| Block Courses in 1st Quarter of the Semester From 17.09.2024 to 9.10.2024 | |||||||||||||||||||||||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | ||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 551-1129-00L | Understanding and Engineering Microbial Metabolism  Number of participants limited to 6. The enrolment is done by the D-BIOL study administration. | W | 6 credits | 7P | J. Vorholt-Zambelli | ||||||||||||||||||||||||||||||||||||||||
| Abstract | The focus of this laboratory course is on current research topics related to metabolic engineering and the general understanding of metabolism, particularly in relation to one carbon metabolism. Projects will be carried out in small teams. | ||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course aims at introducing technologies to investigate bacterial metabolism and key principles of metabolic engineering. The main focus of this block course is on practical work and will familiarize participants with complementary approaches, in particular genetic, biochemical and analytical techniques including metabolomics. Results will be presented by students in scientific presentations. Another goal is to learn how to write a scientific report. | ||||||||||||||||||||||||||||||||||||||||||||
| Content | The course and will include topics such as pathway elucidation & engineering and related ongoing research projects in the lab. Experimental work applied during the course will comprise methods such as cloning work & transformation, growth determination, enzyme activity assays, liquid-chromatography mass-spectrometry and dynamic labeling experiments. | ||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | None | ||||||||||||||||||||||||||||||||||||||||||||
| Literature | Will be provided at the beginning of the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||
| 551-1421-00L | The Mechanisms of Natural Transformation in Competent Gram-Negative Bacteria Number of participants limited to 5. The enrolment is done by the D-BIOL study administration. | W | 6 credits | 7P | M. Hospenthal | ||||||||||||||||||||||||||||||||||||||||
| Abstract | Students will carry out defined research projects related to the current research topics of the Hospenthal group. The topics will include protein expression of pilins and/or other competence proteins from Gram-negative bacteria, protein purification using affinity chromatography, crystallisation experiments and analysis of assembled pili by electron microscopy. | ||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The course should enable students to understand concepts of protein expression, purification and the characterisation of biomolecular interactions. In addition, students will learn some basic principles of X-ray crystallography and electron microscopy. | ||||||||||||||||||||||||||||||||||||||||||||
| Content | The students will be tutored in their experimental work by an experienced doctoral student. The course will also include a short lecture delivered by M. Hospenthal, providing the theoretical background for the experimental work. Throughout the course, students will receive exercises that further help to explain the theory of the practical work, as well as literature research tasks. Participation in the following Hospenthal lab projects will be possible: • Purification, biophysical characterisation and structure determination of pilins • Purification, biophysical characterisation and structure determination of proteins and protein complexes involved in natural transformation. Experimental work on this project involves: • Cloning and mutagenesis • Recombinant or endogenous protein production in E. coli or Legionella • Protein purification by affinity chromatography (other chromatographic purification techniques will also be discussed) • Protein crystallisation and crystal optimisation • Visualisation of bacterial pili by electron microscopy (negative stain or cryo electron microscopy) • DNA binding experiments • Enzymatic activity measurements • In silico structural analyses using PyMOL and Chimera | ||||||||||||||||||||||||||||||||||||||||||||
| Literature | Any required reading of literature will be discussed at the beginning of the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Prerequisites / Notice | There are no special requirements for this course. | ||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||
| 551-0337-00L | Cell Biology of the Nucleus Number of participants limited to 14. The enrolment is done by the D-BIOL study administration. | W | 6 credits | 7P | R. Kroschewski, Y. Barral, M. Jagannathan, S. Jessberger, K. Weis | ||||||||||||||||||||||||||||||||||||||||
| Abstract | Introduction to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. | ||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | The aim of our course is to introduce the students to the organizational principles of the nucleus using budding yeast, drosophila and vertebrate cells as model systems. Emphasis is given to: • Establishment of nuclear identity and nuclear-cytoplasmic communication • Reorganization of the nucleus in aging • Animal cells during the generation of cell diversity and neuronal differentiation By the end of the course, based on lectures, literature reading and practical lab work, the students will be able to formulate open questions concerning the function of the nucleus. Thus, the students will know about the mechanisms and consequences of nuclear-cytoplasmic compartmentalization, DNA clustering in the nucleus and cytoplasm during cell divisions and aging. | ||||||||||||||||||||||||||||||||||||||||||||
| Content | During this block-course, the students will - learn how organelles establish and maintain identity with a focus on the nucleus - discover the evolutionary and functional plasticity of the nucleus - design, apply, evaluate and compare experimental strategies Students - in groups of 2 or max. 3 - will be integrated into a research project connected to the subject of the course, within one of the participating research groups. Lectures and technical notes will be given and informal discussions held to provide you with the theoretical background. | ||||||||||||||||||||||||||||||||||||||||||||
| Lecture notes | About 1 week before course start you will be invited to express your preference for a practical lab project on the course moodle site. Optional papers linked to the projects shall support you in that choice. They can also serve as framework orientation for the practical parts of this block course. | ||||||||||||||||||||||||||||||||||||||||||||
| Literature | Documentation and recommended literature (review articles) will be provided during the course. | ||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||
| 551-1525-00L | Cancer Progression: Mechanisms, Targets and Therapeutic Approaches Number of participants limited to 15. The enrolment is done by the D-BIOL study administration. | W | 6 credits | 7P | N. Aceto, W. Kovacs | ||||||||||||||||||||||||||||||||||||||||
| Abstract | This course will consider the pathogenetic landscape of cancer and its progression to metastasis, explore how abnormalities of cellular information management cause cancer and demonstrate how the integrated application of modern profiling technologies, mouse cancer models and human pathology provides a foundation for developing individualized cancer therapeutics. | ||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | Insights into and overview about the genetic and metabolic alterations that underlie different cancer types, the complex cancer cell circuitries governing tumor development, progression, and metastasis. Understanding of modern approaches used in contemporary basic and translational cancer research and sophisticated strategies to control individual cancers and combat drug resistance. The course is closely linked to ongoing research projects in the lab to provide the participants with direct insights into current experimental approaches and strategies. Student assessment is a graded performance based on individual performance in the laboratory, a written report of their data and a presentation of a recent paper published in a top ranking international peer reviewed journal that relates to cancer. | ||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||
| 551-0352-00L | Introduction to Mass Spectrometry-Based Proteomics Number of participants limited to 12. The enrolment is done by the D-BIOL study administration. | W | 6 credits | 7P | L. Gillet, V. Cappelletti, P. Picotti | ||||||||||||||||||||||||||||||||||||||||
| Abstract | Protein Analysis by Mass Spectrometry The following topics will be covered: basics of biological mass spectrometry, including instrumentation, data collection and data analysis; applications to protein identification and characterization; sample preparation methods; proteomics strategies; and quantitative analysis. | ||||||||||||||||||||||||||||||||||||||||||||
| Learning objective | How to prepare a protein sample for MS analysis (trypsin digestion, C18 clean-up) Principles of data acquisition LC-MS (QTOF and/or Ion Trap instruments) Perform qualitative proteomic analysis (protein identification with Mascot and/or Sequest Softwares) Perform quantitative proteomic analysis (label-free and labeled analyses) Analyze/interpret the data to find up/down regulated proteins | ||||||||||||||||||||||||||||||||||||||||||||
| Competencies |
| ||||||||||||||||||||||||||||||||||||||||||||
Page
1
of
1
