Search result: Catalogue data in Autumn Semester 2023
Biochemistry - Chemical Biology Master  | ||||||||||||||||||||||||
 Electives | ||||||||||||||||||||||||
| Number | Title | Type | ECTS | Hours | Lecturers | |||||||||||||||||||
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| 551-1409-00L | RNA Biology Lecture Series II: Non-Coding RNAs: Biology and Therapeutics | W | 4 credits | 2V | J. Hall, M. Stoffel, further lecturers | |||||||||||||||||||
| Abstract | This course covers aspects of RNA biology related to the functions of non-coding RNAs as well as their use as drugs to treat diseases. | |||||||||||||||||||||||
| Learning objective | The students should get familiar with the wide array of roles, which non-coding RNAs play in cellular functions. | |||||||||||||||||||||||
| Content | Micro RNAs; computational approaches to miRNAs; micro RNA function in metabolism; viruses and viral RNAs; nucleic acid-based drugs; ncRNA-mediated genome regulation; epigenetic programming of genome remodelling in ciliates; telomerase and telomeres; tRNA biology. http://www.nccr-rna-and-disease.ch/tiki-index.php?page=LectureSeries | |||||||||||||||||||||||
| Prerequisites / Notice | Basic knowledge of cell and molecular biology. | |||||||||||||||||||||||
| 529-0243-01L | Transition Metal Catalysis: From Mechanisms to Applications | W | 6 credits | 3G | B. Morandi | |||||||||||||||||||
| Abstract | Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint | |||||||||||||||||||||||
| Learning objective | Understanding and critical evaluation of current research in transition metal catalysis. Design of mechanistic experiments to elucidate reaction mechanisms. Synthetic relevance of transition metal catalysis. Students will also learn about writing an original research proposal during a workshop. | |||||||||||||||||||||||
| Content | Detailed discussion of selected modern transition metal catalyzed reactions from a synthetic and mechanistic viewpoint. Synthetic applications of these reactions. Introduction and application of tools for the elucidation of mechanisms. Selected examples of topics include: C-H activation, C-O activation, C-C activation, redox active ligands, main group redox catalysis, bimetallic catalysis. | |||||||||||||||||||||||
| Lecture notes | Lecture slides will be provided online. A Handout summarizing important concepts in organometallic and physical organic chemistry will also be provided. Useful references and handouts will also be provided during the workshop. Slides will be uploaded 1-2 days before each lecture on http://morandi.ethz.ch/education.html | |||||||||||||||||||||||
| Literature | Primary literature and review articles will be cited during the course. The following textbooks can provide useful support for the course: - Anslyn and Dougherty, Modern Physical Organic Chemistry, 1st Ed., University Science Books. - Crabtree R., The Organometallic Chemistry of the Transition Metals, John Wiley & Sons, Inc. - Hartwig J., Organotransition Metal Chemistry: From Bonding to Catalysis, University Science Books. - J. P. Collman, L. S. Hegedus, J. R. Norton, R. G. Finke, Principles and Applications of Organotransition Metal Chemistry. | |||||||||||||||||||||||
| Prerequisites / Notice | Required level: Courses in organic and physical chemistry (kinetics in particular) of the first and second year as well as ACI and III | |||||||||||||||||||||||
| Competencies |
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